The history and rationale of the development of new drugs for migraine treatment
Pedro André Kowacs,
Pedro Augusto Sampaio Rocha-Filho,
Mário Fernando Prieto Peres
et al.
Abstract:Migraine is one of the most prevalent and disabling diseases in the world. Migraine attack treatments and prophylactic treatments of this disease are essential to lessen its individual, social, and economic impact. This is a narrative review of the main drugs used for treating migraine, as well as the experimental models and the theoretical frameworks that led to their development. Ergot derivatives, triptans, non-steroid anti-inflammatory drugs, tricyclic antidepressants, beta-blockers, flunarizine, valproic … Show more
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