Prediction and prevention of preeclampsia

Peixoto‐Filho, Fernando Maia; Costa, Fabrício da Silva; Kobayashi, Sérgio; Beitune, Patrícia El; Garrido, Adriana; Carmo, A. V.; Rezende, Guilherme de Castro; Werner, Heron; Amin, Joffre; Leão, J.; Nardozza, Luciano Marcondes Machado; Machado, Luiz Eduardo; Sarno, Manoel; Neto, Pedro Pires Ferreira; Júnior, Eduardo Becker

doi:10.1055/s-0043-1763495

Cited by 4 publications

(2 citation statements)

References 45 publications

(64 reference statements)

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“…This is a pioneering study, as this is the first to explore the relationship between CHI3L1 gene polymorphisms and preeclampsia. Preeclampsia is a significant cause of maternal morbidity and mortality, and currently, no standard screening tests are available for its diagnosis, as indicated by previous studies 12 , 13 .…”

Section: Discussionmentioning

confidence: 99%

The role of the Chitinase 3-Like 1 (CHI3L1) genes in the preeclampsia pathophysiology

Mammadova,

Özler,

Özdemir

et al. 2024

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: The aim of this study was to investigate the relationship between Chitinase 3-Like 1 gene polymorphisms and the occurrence of preeclampsia in a selected cohort of pregnant women. METHODS: A total of 75 pregnant women participated in the study, 35 of whom were diagnosed with preeclampsia, while 40 served as healthy controls. The preeclamptic group was subdivided based on severity. Real-time polymerase chain reaction was employed to analyze the serum samples for variations in Chitinase 3-Like 1 gene polymorphisms. RESULTS: The rs880633 polymorphism was found to be significantly more frequent in the control group (80%) compared with the overall preeclamptic group (60%) (p<0.05). In the severity-based subgroups, rs880633 appeared in 57.1% of non-severe and 61.9% of severe preeclamptics. Contrarily, the heterozygous form of rs7515776 polymorphism showed a significantly higher prevalence in the preeclamptic cohort (p<0.05), without distinctions in severity subgroups. CONCLUSION: The study suggests that the rs880633 polymorphism may serve a protective role against the development of preeclampsia, whereas the rs7515776 polymorphism may be associated with an elevated risk. Further research is warranted to elucidate the clinical implications of these findings.

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Section: Discussionmentioning

confidence: 99%

The role of the Chitinase 3-Like 1 (CHI3L1) genes in the preeclampsia pathophysiology

Mammadova,

Özler,

Özdemir

et al. 2024

Rev. Assoc. Med. Bras.

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“…Pasien preeklampsia seringkali memerlukan monitroing kesehatan yang ketat oleh tenaga kesehatan karena risiko mortalitasnya yang tinggi. Pada kondisi kehamilan yang berisiko tinggi, terutama pada ibu hamil dengan usia lanjut, beberapa penggunaan obat seperti aspirin diperlukan pada pasien dengan risiko tinggi selama proses skrining kehamilan, namun perlu diwaspadai efeknya selama kehamilan seperti perdarahan dari jalan lahir (Ma'ayeh dan Costantine, 2020;Peixoto-Filho et al, 2023). Penggunaan obat antihipertensi seperti nifedipin dan labetolol juga bermanfaat untuk menurunkan tekanan darah selama kehamilan dengan mengurangi efek kerusakan pembuluh darah akibat preeklampsia (Sakowicz et al, 2023).…”

Section: Tabel 1 Karakteristik Pasien Preeklampsia DI Rsud Wonogiriunclassified

Karakteristik Pasien Preeklampsia Di Rumah Sakit Umum Daerah Soediran Mangun Soemarso Wonogiri Jawa Tengah

Weningtyas,

Adnan,

Pramaningtyas

et al. 2024

inisiasi

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Preeclampsia is a condition of increased blood pressure accompanied by proteinuria during pregnancy. Preeclampsia is one of the causes of maternal and fetal death. Efforts to reduce the incidence of preeclampsia are one of the efforts to reduce maternal mortality, one of which is by knowing the characteristics of preeclampsia patients to plan to overcome the risk of preeclampsia in the future. This study aims to determine the characteristics of preeclampsia patients at Wonogiri Regional Hospital dr. Soediran Mangun Soemarso, Wonogiri, Central Java. This research was conducted in a retrospective cross-sectional manner on the medical records of preeclampsia patients in Wonogiri Regional Hospital dr. Soediran Mangun Soemarso, Wonogiri, Central Java during 2019-2022. Sampling was carried out using a purposive sampling method among pregnant women who gave birth in the hospital from November 2021 – Januari 2022. A total of 106 medical record data from pregnant women were obtained in this study. The average age of pregnant women in this study was 31.37 ± 6.72 years with the majority aged 20 – 35 years with a history of giving birth more than twice. The majority of preeclampsia patients at Wonogiri Regional Hospital were severe preeclampsia patients (53.8%). A total of 59 pregnant women gave birth using the vaginal delivery method and 47 pregnant women gave birth using the cesarean method. Maternal age and pregnancy history are factors related to the risk of preeclampsia which can influence the mother's delivery method. Further research is needed on risk factors for preeclampsia in a wider population so as to improve the health of mothers and babies during pregnancy

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Biogenesis and function of exosome lncRNAs and their role in female pathological pregnancy

Wang,

Zheng,

et al. 2023

Front. Endocrinol.

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Preeclampsia, gestational diabetes mellitus, and recurrent spontaneous abortion are common maternal pregnancy complications that seriously endanger women’s lives and health, and their occurrence is increasing year after year with a rejuvenation trend. In contrast to biomarkers found freely in tissues or body fluids, exosomes exist in a relatively independent environment and provide a higher level of stability. As backbone molecules, guidance molecules, and signaling molecules in the nucleus, lncRNAs can regulate gene expression. In the cytoplasm, lncRNAs can influence gene expression levels by modifying mRNA stability, acting as competitive endogenous RNAs to bind miRNAs, and so on. Exosomal lncRNAs can exist indefinitely and are important in intercellular communication and signal transduction. Changes in maternal serum exosome lncRNA expression can accurately and timely reflect the progression and regression of pregnancy-related diseases. The purpose of this paper is to provide a reference for clinical research on the pathogenesis, diagnosis, and treatment methods of pregnancy-related diseases by reviewing the role of exosome lncRNAs in female pathological pregnancy and related molecular mechanisms.

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Prediction and prevention of preeclampsia

Cited by 4 publications

References 45 publications

The role of the Chitinase 3-Like 1 (CHI3L1) genes in the preeclampsia pathophysiology

The role of the Chitinase 3-Like 1 (CHI3L1) genes in the preeclampsia pathophysiology

Karakteristik Pasien Preeklampsia Di Rumah Sakit Umum Daerah Soediran Mangun Soemarso Wonogiri Jawa Tengah

Biogenesis and function of exosome lncRNAs and their role in female pathological pregnancy

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