National Cancer Institute and the 2023 -2025 Estimate – Cancer Incidence in Brazil

Primo, Walquíria Quida Salles Pereira

doi:10.1055/s-0043-1762925

Cited by 4 publications

(4 citation statements)

References 5 publications

(5 reference statements)

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“…Among the results analyzed and obtained, it was evidenced the need to work with the theme, aiming to present and elucidate the importance of the Blue November, a worldwide campaign that seeks to bring information about care, prevention, promotion and quality in health and share about the characteristics of the disease, importance of early diagnosis, types of treatments and nursing care from the humanized welcoming, planning, care plan and reassessment of the client, also describing Primary Health Care as the gateway to the Unified Health System (SUS), where the performance of examinations, consultations and referral for the performance of examinations are fundamental pillars to improve the quality of life and health of men, where according to the Ministry of Health (MS), Prostate CA is a public health problem, ranking second among the male population, behind only non-melanoma cancer [2].…”

Section: Resultsmentioning

confidence: 99%

“…In males, prostate cancer is the one with the greatest impact worldwide [1]. According to the National Cancer Institute (INCA), it will be the most incident malignant neoplasm in males, in each year of the triennium from 2023 to 2025, in Brazil, 71,730 new cases are expected, which corresponds to an estimated risk of 67.86 per 100 thousand men [2].…”

Section: Introductionmentioning

confidence: 99%

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Main Challenges in the Prevention of Prostate Cancer in Primary Health Care

Anjos

Formigosa

Dergan

et al. 2023

ACRI

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Introduction: Prostate cancer is a public health problem and the second most common type of cancer in the male population. Objective: To report the experience of a health education action carried out by nursing students. Methodology: This is a descriptive study of the type experience report, carried out in November 2022, in a Family Health Strategy in the Municipality of Ananindeua, alluding to the Blue November, where a group of Nursing students addressed about men's health, elucidating about prostate cancer. Results: In the action in men's health, the active search was essential to relocate the individuals to the health unit, where the approach on the basic concepts of cancer, introduction to the disease, later correlating with prostate cancer (CA), where the male audience showed interest in the lecture, including interacting with the group, seeking to solve doubts about the disease, was highlighted. Conclusion: The approach in spite of cancer, therefore, is essential to the population, such as the male population, where information, debates and explanations about the subject generates knowledge and positive changes in health, in addition to the experience of nursing students was essential to share information in public health, especially about men's health.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Main Challenges in the Prevention of Prostate Cancer in Primary Health Care

Anjos

Formigosa

Dergan

et al. 2023

ACRI

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“…In Brazil, breast cancer ranks as the most prevalent cancer in women across all regions, second only to non-melanoma skin cancer. The estimated number of new cases in 2024 is approximately 70,000 [1]. While hereditary factors contribute to less than 10% of breast cancer cases, identifying carriers of pathogenic variants associated with increased cancer risk remains a potentially cost-effective healthcare strategy, given the high annual case volume and improved prognosis with early detection [2].…”

Section: Introductionmentioning

confidence: 99%

Hereditary breast cancer next-generation sequencing (NGS) panel evaluation in the south region of Brazil: a novelBRCA2candidate pathogenic variant is reported

Duarte,

Santos,

de Oliveira

et al. 2024

Preprint

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In this article, we delineate a loosely selected cohort comprising patients with a history of early-onset breast cancer and/or a familial occurrence of cancer. The aim of this study was to gain insights into the presence of breast cancer-related gene variants in a population from a micro-region in southern Brazil, specifically the Metropolitan Region of Curitiba. This area exhibits a highly genetically mixed population, mirroring the general characteristics of the Brazilian people. Comprehensive next-generation sequencing (NGS) multigene panel testing was conducted, involving the evaluation of twelve patients. Two pathogenic variants and one candidate pathogenic variant were identified: BRCA2:c.8878C>T, p.Gln2960Ter; CHEK2:c.1100delAG>A, p.Thr367Metfs*15 and BRCA2:c.3482dupG>GA, p.Asp1161Glufs*3, a novel variant, previously unpublished, is reported.

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“…The American Cancer Society estimates 300,590 new cases and 43,700 deaths from breast cancer in 2023 [2]. In Brazil, the latest incidence of breast cancer in 2023 rose by 29.7% compared to the previous three years [3]. Breast cancer is a complex disease with important genetic, environmental, and lifestyle or behavioral components.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Action of Isoflavone Derived from Soy-Based Tempeh as an Antioxidant and Breast Cancer Inhibitor via Potential Upregulation of miR-7-5p: A Multimodal Analysis Integrating Pharmacoinformatics and Cellular Studies

Nurkolis,

Taslim,

Lee

et al. 2024

Antioxidants

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Breast cancer presents a significant global health challenge with rising incidence rates worldwide. Despite current efforts, it remains inadequately controlled. Functional foods, notably tempeh, have emerged as promising candidates for breast cancer prevention and treatment due to bioactive peptides and isoflavones exhibiting potential anticancer properties by serving as antioxidants, inducing apoptosis, and inhibiting cancer cell proliferation. This study integrates pharmacoinformatics and cellular investigations (i.e., a multifaceted approach) to elucidate the antioxidative and anti-breast cancer properties of tempeh-derived isoflavones. Methodologies encompass metabolomic profiling, in silico analysis, antioxidant assays, and in vitro experiments. Daidzein and genistein exhibited potential therapeutic options for breast cancer treatment and as antioxidant agents. In vitro studies also supported their efficacy against breast cancer and their ability to scavenge radicals, particularly in soy-based tempeh powder (SBT-P) and its isoflavone derivatives. Results have demonstrated a significant downregulation of breast cancer signaling proteins and increased expression of miR-7-5p, a microRNA with tumor-suppressive properties. Notably, the LD50 values of SBT-P and its derivatives on normal breast cell lines indicate their potential safety, with minimal cytotoxic effects on MCF-10A cells compared to control groups. The study underscores the favorable potential of SBT-P as a safe therapeutic option for breast cancer treatment, warranting further clinical exploration.

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National Cancer Institute and the 2023 -2025 Estimate – Cancer Incidence in Brazil

Cited by 4 publications

References 5 publications

Main Challenges in the Prevention of Prostate Cancer in Primary Health Care

Main Challenges in the Prevention of Prostate Cancer in Primary Health Care

Hereditary breast cancer next-generation sequencing (NGS) panel evaluation in the south region of Brazil: a novelBRCA2candidate pathogenic variant is reported

Mechanism of Action of Isoflavone Derived from Soy-Based Tempeh as an Antioxidant and Breast Cancer Inhibitor via Potential Upregulation of miR-7-5p: A Multimodal Analysis Integrating Pharmacoinformatics and Cellular Studies

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