Melena Passing in Langya Henipavirus and Severity of Infection: A Concern

Sookaromdee, Pathum; Wiwanitkit, Viroj

doi:10.1055/s-0042-1757775

Cited by 1 publication

(3 citation statements)

References 2 publications

(6 reference statements)

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“…3,5,15,22 In addition, severe cases may result in thrombocytopaenia, which may cause melaena, gingival bleeding, and abdominal discomfort. 3,5,15,22,24,25 In severe cases, patients may experience abnormal neurological symptoms or dysfunctions of the liver and kidney. 5,16,24 Serious complications associated with LayV can cause long-lasting harm to the health of patients.…”

Section: Clinical Aspects and Human-to-human Transmissibilitymentioning

confidence: 99%

“…Patients can manifest with fever, cough, expectoration, headache, myalgia, nausea, vomiting, fatigue, poor appetite, and lymphadenopathy 3,5,15,22 . In addition, severe cases may result in thrombocytopaenia, which may cause melaena, gingival bleeding, and abdominal discomfort 3,5,15,22,24,25 . In severe cases, patients may experience abnormal neurological symptoms or dysfunctions of the liver and kidney 5,16,24 .…”

Section: Clinical Aspects and Human‐to‐human Transmissibilitymentioning

confidence: 99%

“…-LayV, a Henipahvirus, is likely to use these receptor 17 Incubation period -Not available at the moment Signs and symptoms -Flu-like symptoms: Fever, cough, headache, myalgia, nausea, vomiting, fatigue, low appetite, lymphadenopathy, expectoration 3,5,15,22 -Abdominal pain 32 -Haematological presentations: Leucopenia and thrombocytopaenia 3,5,15,22,24,25 Manifestations of severe illness -No deaths reported as of Aug 2023 23 -Melaena, gingival bleeding 22,25 -Respiratory involvement: Pneumonia 3,5,15,22 -Neurological symptoms (dysphoria, confusion) 5,16,24 -Dysfunctions of the liver or kidney 5,16,24 Diagnosis -Throat swab PCR, ELISA 4 Treatment -Mainly supportive care 19 -Ribavirin, chloroquine, favipiravir 3,6,17,20,26 -Intravenous monoclonal antibody m102.…”

Section: Criteria Layv Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

A comprehensive review of Langya virus and framework for future zoonotic disease control

Thien,

Tran,

Uyen

et al. 2024

Reviews in Medical Virology

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First reported in August 2022, the Langya virus (LayV) has emerged as a potential global health threat in the post‐COVID‐19 era. Preliminary reports show that 35 patients near Shandong and Henan, China experienced a febrile acute LayV infection. We conducted this review following the PRISMA protocol to synthesise current knowledge on LayV's characteristics in terms of molecular, clinical, and public health perspectives. This virus belongs to the Paramyxoviridae family and carries a non‐segmented, single‐stranded negative‐sense RNA genome. Shrews may be the natural reservoir of the virus. Clinical symptoms range from mild flu‐like symptoms to severe manifestations involving pneumonia, haematological disorders, and organ dysfunction. Diagnostic methods include PCR and ELISA assays. Despite the absence of established treatments, antiviral drugs such as ribavirin and chloroquine may be useful in some cases. In light of prevention, a comprehensive approach that emphasises multidisciplinary collaboration is crucial for early surveillance and response. Urgent global efforts are needed for vaccine development and preparedness against this potential pandemic threat. As the viral dynamics remain uncertain, a proactive approach is vital to mitigate the impact of not only LayV but also future threats on a large scale in long term.

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