The COVID-19 Pandemic Impact on Breast Cancer Diagnosis: A Retrospective Study

Negrão, Erika Marina Solla; Cabello, César; Conz, Lívia; Mauad, Edmundo Carvalho; Zeferino, Luíz Carlos; Vale, Diama Bhadra

doi:10.1055/s-0042-1749207

Cited by 9 publications

(6 citation statements)

References 23 publications

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“…In Brazil, cancer screening and diagnosis were more severely affected than treatment, irrespective of the type of cancer (11). A reduction was found in the number of breast cancer diagnoses, with the cases detected suggestive of a poorer prognosis (30), as also shown in our study. The proportion of palpable nodules was significantly greater in 2020 compared to 2019 (31).…”

Section: Discussionsupporting

confidence: 85%

“…The present study showed a reduction in the absolute numbers of cases of cancer notified and a proportional increase in the number of cases diagnosed at more advanced stages during the COVID-19 pandemic, with the number of cases of stages III and IV now surpassing that of stages I and II in all the regions of the country except for the south. Studies conducted both in developed and in developing countries (36,37) have also shown a reduction in the number of cases diagnosed (17,37) and an increase in the number of diagnoses at more advanced stages (30,38).…”

Section: Discussionmentioning

confidence: 99%

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COVID-19 and Breast Cancer in Brazil

Rocha¹,

Freitas‐Júnior

Ferreira

et al. 2023

Int J Public Health

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Objectives: This study aimed to evaluate COVID-19 effects on breast cancer screening and clinical stage at diagnosis in patients of 50–69 years of age receiving care within the public healthcare network (SUS) in 2013–2021 in Brazil and its macro-regions.Methods: This ecological study used Poisson regression to analyze trends in screening and staging. A secondary database was formed using SUS sources: outpatient data system of the SUS network and Oncology—Brazil Panel.Results: There was a reduction in screening, with an annual percent change of −5.9 (p < 0.022). The number of notified cases fell by 31.5% in 2020–2021 compared to 2018–2019. There was a 10.7% increase in the proportion of stage III/IV cases (p < 0.001) in 2020–2021 compared to 2013–2019, now surpassing the number of cases of early stage breast cancer.Conclusion: COVID-19 led to a reduction in breast cancer screening and an expressive increase in advanced tumors in users of the public healthcare network. Urgent interventions in public policies are required as the negative effects of the pandemic on the diagnosis/treatment of breast cancer are becoming apparent even earlier than expected.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

COVID-19 and Breast Cancer in Brazil

Rocha¹,

Freitas‐Júnior

Ferreira

et al. 2023

Int J Public Health

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“…However, the percentage of symptomatic cases (palpable masses) was 79.7% in 2020 and 50.4% in 2019 (P , .001), confirming the delay in the diagnosis of BC caused by the COVID-19 pandemic. 12 Our study has some limitations, two of which are important to highlight. First, this was a retrospective and observational study; therefore, causality could not be assessed.…”

Section: Discussionmentioning

confidence: 95%

Impact of the COVID-19 Pandemic on Cancer Staging: An Analysis of Patients With Breast Cancer From a Community Practice in Brazil

Resende¹,

Cruz²,

Silva³

et al. 2022

JCO Global Oncology

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PURPOSE A nationwide lockdown was enforced in Brazil starting in March 2020 because of the COVID-19 pandemic when cancer screening activities were reduced. In this study, we evaluated the impact of the COVID-19 pandemic on breast cancer (BC) diagnosis. METHODS We extracted data from the medical records of patients age older than 18 years who were diagnosed with BC and started treatment or follow-up in private oncology institutions in Brazil between 2018 and 2021. The primary objective was to compare the stage distribution during the COVID-19 pandemic (2020-2021) with a historical prepandemic control cohort (2018-2019). Early BC was defined as stage I-II and advanced disease as stage IV. RESULTS We collected data for 11,753 patients with an initial diagnosis of BC, with 6,493 patients in the pandemic (2020-2021) and 5,260 patients in the prepandemic period (2018-2019). We observed a lower prevalence of early-stage BC (63.6% v 68.4%) and a higher prevalence of advanced-stage BC (16.9 v 12.7%), after the onset of the pandemic (both P < .01). This pattern was similar for both estrogen receptor–positive/human epidermal growth factor receptor 2–negative and human epidermal growth factor receptor 2–positive tumors: significantly decreased in the early stage from 69% to 67% and 68% to 58%, respectively, and a considerable increase in advanced-stage disease from 13% to 15% and 13% to 20%, respectively. For triple-negative BC, there was a significantly higher percentage of patients with advanced-stage disease during the pandemic (17% v 11%). Overall, age 50 years or older and postmenopausal status were associated with a greater risk of advanced stage at diagnosis during the pandemic period. CONCLUSION We observed a substantial increase in the number of cases of advanced-stage BC in Brazil during the COVID-19 pandemic.

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“…Além da acentuada queda do rastreio nos primeiros 90 dias de pandemia. (Negrao, 2022;Takaki Tachibana, 2021).…”

Section: Resultsunclassified

Os impactos da pandemia COVID-19 no diagnóstico e tratamento do câncer de mama, uma revisão sistemática na literatura

Santos

Campelo

Costa

et al. 2023

RSD

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Introdução: O câncer de mama é o segundo no quesito de maior incidência para o sexo feminino, ficando atrás somente do câncer de pele não melanoma. O advento da pandemia COVID-19 gerou um cenário infrutífero para o diagnóstico e tratamento precoces, impactando diretamente na sobrevida e prognóstico destas pacientes. Medir a extensão de tal impacto é vital para elaborar uma contramedida visando a reparação de tais diagnósticos. Desse modo, o atual estudo propõe-se a realizar uma revisão sistemática na literatura acerca dos impactos da COVID-19 no rastreio e tratamento do câncer de mama no Brasil. Metodologia: Foram buscados na literatura, através das plataformas SCIELO, LILACS e MEDLINE, utilizando os descritores Câncer de mama, COVID-19 associados pelo operador booleano AND, artigos originais resultantes de análises quantitativas e ou qualitativas diretamente acerca das dificuldades impostas pela pandemia COVID-19 ao rastreio e enfrentamento do câncer de mama, no Brasil. Resultados: Foram encontrados 35 artigos, dos quais 10 foram incluídos na análise. Conclusão: Devido a pandemia, houve significativa queda no número de mamografias, redução de diagnósticos de cânceres em estágios iniciais, aumento dos casos de câncer sintomáticos e aumento dos custos com quimioterapia para doenças avançadas.

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The COVID-19 Pandemic Impact on Breast Cancer Diagnosis: A Retrospective Study

Cited by 9 publications

References 23 publications

COVID-19 and Breast Cancer in Brazil

COVID-19 and Breast Cancer in Brazil

Impact of the COVID-19 Pandemic on Cancer Staging: An Analysis of Patients With Breast Cancer From a Community Practice in Brazil

Os impactos da pandemia COVID-19 no diagnóstico e tratamento do câncer de mama, uma revisão sistemática na literatura

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