Association of Serum Calcium and Vitamin D with Benign Paroxysmal Positional Vertigo

Thomas, Ron Jacob; Goutham, MK; Bhat, Vadisha Srinivas; Kamath, Shrinath; Aroor, Rajeshwary; Bhandary, Satheesh Kumar

doi:10.1055/s-0041-1724093

Cited by 7 publications

(6 citation statements)

References 21 publications

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“…Bazoni et al, on the other hand, found no association between 25(OH) vitamin D levels and BPPV in the general population, but noted an association with bone mineral density in the elderly group with diabetes mellitus and BPPV [ 22 ]. While some research findings suggested no association between vitamin D levels and serum calcium in BPPV, a negative correlation was identified between vitamin D concentrations and the frequency of BPPV episodes ( p < 0.012) [ 23 ]. Several studies consistently reported low vitamin D status in patients with BPPV, with no significant differences in 25(OH)D levels between BPPV patients and controls [ 19 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Supplementation and Recurrence of Benign Paroxysmal Positional Vertigo

Rhim,

Kim

2024

Nutrients

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Positional vertigo manifests as a spinning sensation triggered by changes in head position relative to gravity. Benign paroxysmal positional vertigo (BPPV) is an inner ear disorder characterized by recurrent episodes of positional vertigo. The connection between vitamin D insufficiency/deficiency and the onset and recurrence of BPPV is established. This study aims to assess vitamin D as a recurring factor in BPPV and the efficacy of vitamin D supplementation in preventing its recurrence. A comprehensive literature review on the relationship between vitamin D and BPPV recurrence was conducted, searching PubMed, Embase, Web of Science, and article reference lists for studies published from 2020 to 2023. A total of 79 articles were initially identified through the search, with 12 of them being utilized in the study. Recurrence rates for BPPV varied from 13.7% to 23% for studies with follow-up less than 1 year and 13.3% to 65% for studies with follow-up equal to or exceeding 2 years. Risk factors for BPPV recurrence include advanced age, female sex, hypertension, diabetes mellitus, hyperlipidemia, osteoporosis, and vitamin D deficiency. While earlier studies did not establish a link between low vitamin D levels and initial BPPV occurrence, they did associate recurrent episodes with low vitamin D levels. Recent research indicates that vitamin D supplementation in BPPV patients with deficiency or insufficiency decreases both the numbers of relapsing patients and relapses per patient. To validate these findings across diverse populations, further randomized controlled studies with larger cohorts and extended follow-up durations are essential.

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Section: Discussionmentioning

confidence: 99%

Vitamin D Supplementation and Recurrence of Benign Paroxysmal Positional Vertigo

Rhim,

Kim

2024

Nutrients

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“…A study from Croatia reported that low vitamin D3 serum level is not a risk factor for BPPV recurrence [10]. Another study from India concluded that there is no association between calcium and vitamin D concentrations and BPPV [24]. A recent investigation from the United States found that BPPV patients had a significantly higher vitamin D level than the NHANES (National Health and Nutrition Examination Survey) individuals (31.4 ±16.5 vs. 26.0 ±11.2 ng/mL, d = 0.474 (0.323, 0.626)) [16].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency and the Risk of Recurrent Benign Paroxysmal Positional Vertigo

Saeed Al-Rawi,

Al-Ani

2024

Cureus

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BackgroundBenign paroxysmal positional vertigo (BPPV) is the most common cause of positional vertigo. It is a shortlived (seconds) rotatory attack of vertigo in relation to the position of the head. Vitamin D deficiency may be one of the causes leading to BPPV. As there is no relevant local study from Iraq, this study aimed to evaluate the association between BPPV and vitamin D deficiency. MethodologyThis retrospective, case-control study was conducted at the otolaryngology clinic of Al-Ramadi Teaching Hospital during a 26-month duration. The study included 40 patients clinically diagnosed with BPPV and 80 individuals as controls. Detailed information regarding the demographic and clinical characteristics was obtained from each participant. Serum vitamin D and calcium levels were measured for each participant. ResultsBoth cases and controls were matched regarding age and gender. Serum vitamin D level in cases (15.458 ± 6.14 ng/mL) was lower than controls (23.604 ± 12.58 ng/mL), with a p-value of 0.0001 and large clinical effect size (0.8). Vitamin D deficiency was found in 35 cases and 37 controls, with a highly significant difference (p = 0.0001) and an odds ratio of 8.135. Vitamin D deficiency in BPPV patients with recurrence (12.615 ± 4.096 ng/mL) was lower than those without recurrence (18.3 ± 6.611 ng/mL), with a highly significant difference (p = 0.002) and small clinical effect size (0.3). Older age and vitamin D deficiency were risk factors for recurrence according to the multinominal logistic regression test (p < 0.05). ConclusionsVitamin D deficiency might cause the occurrence and recurrence of BPPV. Older age might be a risk factor for BPPV recurrence.

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“…A total of 12 studies reported that compared with controls, patients with BPPV have lower average serum vitamin D levels 1 26–35. Seven studies found no significant difference between the serum vitamin D levels of BPPV patients and controls 36–42. Among cases and controls with osteoporosis and osteopenia, two studies2 43 found no significant difference between cases and controls, although osteoporosis was correlated with low serum vitamin D in BPPV patients 2.…”

Section: Quality Assessmentmentioning

confidence: 99%

“…The relationship between BPPV recurrence and serum 25-hydroxyvitamin D was examined in 12 studies, with 9 studies reporting lower serum vitamin D levels in patients with recurrent BPPV compared with those experiencing an initial attack1 31 35–37 42 45 46 and 3 reporting no significant difference in vitamin D levels between the 2 groups 38 47 48. Three studies41 49 50 reported that vitamin D supplementation reduced the number of recurrent episodes of BPPV.…”

Section: Quality Assessmentmentioning

confidence: 99%

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Association between vitamin D deficiency and benign paroxysmal positional vertigo (BPPV) incidence and recurrence: a systematic review and meta-analysis

Wood,

Kluk,

BinKhamis

2024

BMJ Open

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ObjectivesThe objective of this study is to determine the relationship between serum vitamin D level and the risk of developing benign paroxysmal positional vertigo (BPPV) incidence and recurrence in countries in the Northern Hemisphere.DesignSystematic review and meta-analysis.Data sourcesPubMed, Scopus and Web of Science databases were searched for studies published between January 2000 and February 2023.Eligibility criteria for selecting studiesParticipants located in the Northern Hemisphere aged 18 or over with at least one episode of BPPV, serum 25-hydroxyvitamin D levels measured and reported, no comorbidities or history of vitamin D supplementation.Data extraction and synthesisData extraction and synthesis were performed by a single reviewer and checked by a second reviewer. Inclusion and exclusion criteria and risk of bias were assessed by two independent reviewers using the Newcastle Ottawa Tool for Cohort studies and Risk of Bias Assessment Tool for Nonrandomised Studies checklist for case–control studies. Meta-analysis was conducted using random effects models. Standard mean difference with a 95% CI was used to measure the relationship between vitamin D level and BPPV.ResultsThe 35 articles identified by the literature search reported data of 9843 individuals. 19 studies (7387 individuals) were included in the BPPV incidence meta-analysis while 7 studies (622 individuals) were included in the BPPV recurrence meta-analysis. Lower serum vitamin D levels were found in BPPV incidence compared with controls, but the relationship between vitamin D levels in recurrent BPPV compared with non-recurrent disease remained uncertain.ConclusionResults of this systematic review and meta-analysis demonstrated a negative correlation between serum vitamin D and BPPV incidence, while any relationship between serum vitamin D and BPPV recurrence remained uncertain. Risk of bias analysis revealed evidence of variable quality. There were insufficient data available to evaluate seasonal relationships between serum vitamin D and BPPV. Given the potential for this as a confounding factor, future research should aim to investigate this further.PROSPERO registration numberCRD42021271840.

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Association of Serum Calcium and Vitamin D with Benign Paroxysmal Positional Vertigo

Cited by 7 publications

References 21 publications

Vitamin D Supplementation and Recurrence of Benign Paroxysmal Positional Vertigo

Vitamin D Supplementation and Recurrence of Benign Paroxysmal Positional Vertigo

Vitamin D Deficiency and the Risk of Recurrent Benign Paroxysmal Positional Vertigo

Association between vitamin D deficiency and benign paroxysmal positional vertigo (BPPV) incidence and recurrence: a systematic review and meta-analysis

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