Antioxidant Effect of Curcumin on the Prevention of Oxidative Damage to the Cochlea in an Ototoxic Rat Model Based on Malondialdehyde Expression

Abstract

Introduction Aminoglycoside, as an antimicrobial medication, also has side-effects on the inner ears, bringing about hearing disorders. Curcumin has been proven to be a strong scavenger against various reactive oxygen species (ROS), and the increase in ROS production is considered to play an important role in the process of hearing disorder. Objective To prove that curcumin is an effective antioxidant to prevent cochlear damage based on malondialdehyde (MDA) expression. Methods The present research used 32 Rattus norvegicus, of the Wistar lineage, randomly divided into 8 groups: negative control, ototoxic control (a single dose of 40 mg/ml of gentamicin via intratympanic injection), 2 groups submitted to ototoxic control + curcumin treatment (100 mg/kg, 200 mg/kg), 2 groups who iunderwent ototoxic control + curcumin treatment for 7 days, and two groups submitted to curcumin treatment as prevention for 3 days + ototoxic induction. Results The results showed that the lowest dosage of curcumin (100 mg/kg) could decrease MDA expression on the cochlear fibroblastic wall of the ototoxic model; however using greater doses of curcumin (200 mg/kg) for 7 days would provide a better effect. Curcumin could also significantly decrease MDA expression when it was administered during the preototoxic exposure. Conclusion Curcumin can be used as a therapy for ototoxic prevention based on the decrease in MDA expression.

Synthesis, Cytotoxicity and Molecular Docking of New Hybrid Compounds by Combination of Curcumin with Oleanolic Acid

“…Lipid peroxidation is significantly reduced in rats treated with curcumin before applying γ-radiation [ 17 ]. Curcumin increases enzymatic antioxidant activity by increasing the expression of methionine sulfoxide reductase (MSRA) and increasing the levels of the enzymes MSRA, SOD, CAT and GPx [ 18 ], and may act as an antioxidant against oxidative stress in rats with diabetes mellitus by increased SOD expression in cochlear fibroblasts [ 19 ]. This compound can be considered as a promising antibacterial agent, but with very selective activity towards individual species and strains.…”

Bisdemethoxycurcumin-mediated Attenuation of Apoptosis Prevents Gentamicin-induced Ototoxicity in Mouse Cochlear UB/OC-2 Cells

“…Curcumin, the major component in turmeric, has been extensively studied (12)(13)(14)(15). It protects rat cochlear fibroblasts and might prevent apoptotic pathway in gentamicin-induced ototoxicity (16,17). To the best of our knowledge, there are no reports on BDMC, one of the rarest compounds in nature, in relation to AG-induced ototoxicity.…”