Physical Performance Regarding Handgrip Strength in Women with Polycystic Ovary Syndrome

Kogure, Gislaine Satyko; Ribeiro, Victor Barbosa; Gennaro, Flávia Ganoa de Oliveira; Ferriani, Rui Alberto; Furtado, Cristiana Libardi Miranda; Reis, Rosana Maria dos

doi:10.1055/s-0040-1718953

Cited by 6 publications

(9 citation statements)

References 34 publications

(39 reference statements)

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“…In our study, patients with PCOS had higher H FFM values compared to the controls, although the causes are not yet clear. Kogure et al found that women with PCOS had greater muscle strength with respect to controls matched for body composition, but they justified this result based on the difference in androgenic patterns present in their groups [ 17 ]. Another study comparing PCOS subjects with hyperandrogenism and controls showed the same strength levels [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…The underlying physiological mechanisms between strength and cardiovascular benefits are not fully understood, particularly in the PCOS population [ 16 ]. Conflicting results were found in the literature when assessing strength in women with PCOS [ 17 , 18 ]. Thus, the purpose of our observational study is to assess CRF and strength in women with and without PCOS who were matched in terms of age, body composition and androgenic and insulinemic patterns.…”

Section: Introductionmentioning

confidence: 99%

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Do Androgenic Pattern, Insulin State and Growth Hormone Affect Cardiorespiratory Fitness and Strength in Young Women with PCOS?

et al. 2022

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In this study, cardiorespiratory fitness (CRF) and strength level were assessed in women with and without polycystic ovary syndrome (PCOS), matched for age, body composition, androgenic pattern and insulinemic pattern. Patients with and without PCOS were evaluated at the Endocrinology Unit and Sport Medicine Division to assess endocrinological (insulinemic, androgenic pattern and growth hormone), anthropometric (with DEXA) and functional parameters (with cardiopulmonary exercise test and handgrip test), as well as physical activity level (with the Global Physical Activity Questionnaire). A total of 31 patients with PCOS and 13 controls were included. No statistically significant differences were found between groups in terms of age, body mass index, body composition, androgenic pattern, insulin state, growth hormone and physical activity level. The PCOS group demonstrated significantly better cardiorespiratory fitness (VO2max per kg (30.9 ± 7.6 vs. 24.8 ± 4.1 mL/kg/min; p = 0.010), VO2max per kg of fat-free mass (52.4 ± 8.9 vs. 45.3 ± 6.2 mL/kg/min; p = 0.018)), strength levels (handgrip per kg (0.36 ± 0.09 vs. 0.30 ± 0.08; p = 0.009), handgrip per kg of fat-free mass (13.03 ± 2.32 vs. 11.50 ± 1.91; p = 0.001)) and exercise capacity (METs at test (14.4 ± 2.72 vs. 12.5 ± 1.72 METs; p = 0.019)). In this study, women with PCOS showed a better cardiorespiratory fitness and strength than the control group. The only determinant that could explain the differences observed seems to be the presence of the syndrome itself. These results suggest that PCOS per se does not limit exercise capacity and does not exclude good functional capacity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Do Androgenic Pattern, Insulin State and Growth Hormone Affect Cardiorespiratory Fitness and Strength in Young Women with PCOS?

et al. 2022

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“…As mentioned earlier, there are data supporting that athletes with PCOS perform better in strength and aerobic performance tests in relation to testosterone levels than non-PCOS athletes. 4,5,[16][17][18][19] However, most women with PCOS have total testosterone levels within the normal upper range, although levels of free or bioavailable testosterone are increased. By obvious reasons, there are no studies on groups of female athletes with rare disorders of XY DSD and endogenous testosterone in the male range.…”

Section: Endogenous Androgens and Physical Performance In Womenmentioning

confidence: 99%

“…5,11 Furthermore, women athletes and nonathletes with PCOS have greater muscle strength related to levels of bioavailable testosterone and irrespective of body composition in comparison with control women. 5,[16][17][18][19] Athletes with PCOS also exhibit higher aerobic performance levels than non-PCOS athletes (►Fig. 2).…”

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confidence: 99%

Female Hyperandrogenism in Elite Sports and the Athletic Triad

Hirschberg

2021

Semin Reprod Med

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Essential hyperandrogenism seems to be overrepresented in female elite athletes. This applies to mild forms such as polycystic ovary syndrome, as well as rare differences/disorders of sex development (DSD). The reason is likely a selection bias since there is increasing evidence that androgens are beneficial for athletic performance by potent anabolic effects on muscle mass and bone mass, and stimulation of erythropoiesis. XY DSD may cause a greatly increased production of testosterone in the male range, that is, 10 to 20 times higher than the normal female range. The established regulations concerning the eligibility of female athletes with severe hyperandrogenism to compete in the female classification remain controversial. The most common cause of menstrual disorders in female athletes, however, is probably an acquired functional hypothalamic disturbance due to energy deficiency in relation to energy expenditure, which could lead to low bone mineral density and increased risk of injury. This condition is particularly common in endurance and esthetic sports, where a lean body composition is considered an advantage for physical performance. It is important to carefully evaluate endocrine disturbances and menstrual disorders in athletes since the management should be specific according to the underlying cause.

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“…Its characteristic phenotypes include elevated androgen levels, irregular menstruation and polycystic ovary (Manti et al 2020). The hyperandrogenic manifestations of PCOS include dyslipidemia, insulin resistance, type-2 diabetes mellitus (DM2), obesity, cancer, infertility, and coronary heart diseases (Kogure et al 2020). At present, there is evidence to support the key role of elevated androgen levels in PCOS pathogenesis, which affects the function of various tissues of the body, among which skeletal muscle is one of the main targets of androgen.…”

Section: Introductionmentioning

confidence: 99%

HFE Gene Regulation of T Lymphocyte Activity Can Be a Potential Target of PCOS

Song¹,

Chen²,

Wang³

et al. 2022

Preprint

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Background Polycystic ovary syndrome (PCOS) may be characterized by skeletal muscle abnormalities. Pioglitazone has a certain therapeutic effect on skeletal muscle metabolism in PCOS patients.Objective To investigate the other effects of pioglitazone on skeletal muscle and its mechanism.Methods We used weighted gene co-expression network analysis (WGCNA) to identify potential key genes and signaling pathways involved in pioglitazone affecting skeletal muscle in PCOS patients. First, download the chip data of GSE8157 from GEO database. Then, modules related to genes expressed in skeletal muscle of PCOS patients before and after pioglitazone treatment were screened by WGCNA, and core genes and differential gene analysis methods were further selected according to the correlation characteristics between modules and clinical manifestations. Finally, the selected genes were enriched for analysis.Results Four significantly up-regulated genes were screened out by differential gene analysis: MTBP, MAPK14, RBBP6 and PTPRC. They are both associated with cell cycle regulation and immune cell (T cell) antigen receptor signaling.Conclusions The effect of pioglitazone on skeletal muscle of PCOS patients is mainly reflected in the regulation of abnormal expression of cell cycle and immune cell-related genes. Among them, HFE gene has the most obvious regulation effect on T lymphocyte activity, which may be a potential gene target for the treatment of PCOS.

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Physical Performance Regarding Handgrip Strength in Women with Polycystic Ovary Syndrome

Cited by 6 publications

References 34 publications

Do Androgenic Pattern, Insulin State and Growth Hormone Affect Cardiorespiratory Fitness and Strength in Young Women with PCOS?

Do Androgenic Pattern, Insulin State and Growth Hormone Affect Cardiorespiratory Fitness and Strength in Young Women with PCOS?

Female Hyperandrogenism in Elite Sports and the Athletic Triad

HFE Gene Regulation of T Lymphocyte Activity Can Be a Potential Target of PCOS

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