Preeclampsia as an Inaugural Manifestation of Primary Hyperparathyroidism: A Case Report

Leite, Sara Dias; Ormonde, Carolina; Ormonde, Mariana; Raposo, Joana Teresa Botelho Vasconcelos; Sampaio, Joana; Melo, Bruna Carina Da Silva

doi:10.1055/s-0040-1718447

Cited by 2 publications

(3 citation statements)

References 18 publications

(31 reference statements)

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“…Hypertensive crisis leading to preeclampsia is another severe complication of primary hyperparathyroidism during pregnancy. In a vast majority of women, preeclampsia was the main clinical manifestation of primary hyperparathyroidism ( 12 , 17 – 20 ). In an Indian cohort study, the rates of pancreatitis and preeclampsia appearance were 50% and 88%, respectively ( 6 ).…”

Section: Discussionmentioning

confidence: 99%

Parathyroid adenoma in pregnancy: A case report and systematic review of the literature

et al. 2022

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ObjectivePrimary hyperparathyroidism is a common disorder of the parathyroid glands. Parathyroid adenoma (PA) in pregnancy is a relatively rare disease, whose diagnosis and treatment is a challenging task. The aim of the present study is to present a new case of parathyroid adenoma during pregnancy and to give a detailed account of all reported cases of parathyroid adenoma during pregnancy in the literature.Study designA bibliographic research was performed, and characteristics of parathyroid adenomas in pregnancy such as age, gestational week at diagnosis, ionized calcium levels, genetic testing result, symptomatology, radiological method of localization, treatment method, gestational week at operation, and maternal/fetal complications were recorded.ResultsA 34-year-old woman at her 25 weeks’ gestation was diagnosed with parathyroid adenoma and was referred to our Surgical Department due to contraindication for conservative treatment. A parathyroidectomy was performed, and the maternal and fetal postoperative period was uneventful. Two hundred eleven cases of parathyroid adenoma in pregnancy were recorded in the literature, and statistical analysis was performed. The median gestational week at diagnosis was 21 ± 9.61 weeks. The mean level of ionized calcium was 2.69 mmol/l [SD = 0.75 (2.55–2.84 95% CI)]. Most cases were familiar (72.4%), while surgery was the preferred treatment option (67.3%). The majority of cases were asymptomatic (21.7%), and the main radiological method applied for localization was ultrasound (63.4%).ConclusionParathyroid adenoma in pregnancy is a rare condition. The early diagnosis is of great importance as surgical treatment at the second trimester of pregnancy outweighs the maternal and fetal risks.

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Section: Discussionmentioning

confidence: 99%

Parathyroid adenoma in pregnancy: A case report and systematic review of the literature

et al. 2022

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“…The clinical manifestations are increased blood pressure, proteinuria, edema, and organ damage after 20 weeks of pregnancy. [1][2][3][4] It is the primary cause of maternal and perinatal death. Recent studies have suggested that the onset of preeclampsia may be related to uterine spiral artery recasting disorder, vascular endothelial cell damage, insufficient nutritional supply, and genetic factors.…”

Section: Introductionmentioning

confidence: 99%

“…Preeclampsia (PE) is an idiopathic pregnancy disease with a global incidence of 2%–8%. The clinical manifestations are increased blood pressure, proteinuria, edema, and organ damage after 20 weeks of pregnancy 1–4 . It is the primary cause of maternal and perinatal death.…”

Section: Introductionmentioning

confidence: 99%

Circ‐0002814 participates in proliferation and migration through miR‐210 and FUS/VEGF pathway of preeclampsia

Wei

2022

J of Obstet and Gynaecol

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Background: Circular RNA plays a critical role in cell proliferation, differentiation, and autophagy. However, the role and mechanism of circRNA in preeclampsia is yet to be clarified. The present study investigated the function and mechanism of circ-0002814 in preeclampsia. Methods: The expression level of circ-0002814, microRNA 210 (miR210), Notch receptor 1 (Notch1), or cytoplasmic polyadenylation element-binding protein 2 (CPEB2) was investigated by Reverse transcription Realtime Quantitative PCR (RT-qPCR). The level of Notch1, CPEB2, and FUS (FUS RNA-binding protein) proteins was detected by western blot. The localization of circ-0002814 and miR-210 was determined by FISH assay. Cell proliferation and invasion were detected by EdU and transwell assays, respectively. The interaction between circ-0002814 and FUS protein was detected by RNA pulldown assay, while that between circ-0002814 and miR-210 was detected by dual-luciferase reporter assay. Results: The expression of circ-0002814 was decreased in the placenta and plasma of patients with preeclampsia. The ectopic expression of circ-0002814 promoted the invasion and proliferation of HTR8 cells compared to the control group (p < 0.05). Silencing circ-0002814 suppressed the invasion and proliferation of JEG3 cells compared to the control group (p < 0.05). circ_0002814-regulated Notch1 and CPEB2 by interaction with miR-210 and also regulated FUS/VEGF axis in HTR8 and JEG3 cells. Conclusion: A low expression of circ-0002814 was detected in the plasma and placental tissue in preeclampsia patients. circ-0002814 participated in the proliferation and invasion of HTR8 and JEG3 cells. Thus, circ-0002814 may be considered as a potential diagnostic marker and therapeutic target for preeclampsia.

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Preeclampsia as an Inaugural Manifestation of Primary Hyperparathyroidism: A Case Report

Cited by 2 publications

References 18 publications

Parathyroid adenoma in pregnancy: A case report and systematic review of the literature

Parathyroid adenoma in pregnancy: A case report and systematic review of the literature

Circ‐0002814 participates in proliferation and migration through miR‐210 and FUS/VEGF pathway of preeclampsia

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