What the Transcriptome of the Eutopic Endometrium from Women with Endometriosis tells us about the Disease Pathophysiology: A Brief Reflection

Downregulation of DROSHA: Could It Affect miRNA Biogenesis in Endometriotic Menstrual Blood Mesenchymal Stem Cells?

“…Thus, miRNAs may play an essential role in the inflammatory context of illness [ 70 ]. It is possible that this microenvironment contributes to the reduction in DROSHA expression in MenSCs, given that alterations in DROSHA are related to inflammatory processes, as previously described, and that the eutopic endometrium of women with endometriosis III and IV presents a sustained stress profile due to the enrichment of TGF signaling pathways, interferon alpha/gamma responses, and the prevalence of natural killer T cells [ 13 ].…”

“…MenSCs have recently been the subject of studies on the etiology of endometriosis owing to their high proliferation rates, immunomodulatory capacity, migration to inflammatory niches, clinical applications, and roles in regenerative medicine with no ethical dilemma [ 11 , 12 ]. In addition, given the important particularities evidenced in the endometrium of women with endometriosis [ 13 , 14 ], and although the participation of the endometrium as a carrier of changes is not fully understood, tracking molecular alterations in these progenitor cell types could demonstrate their involvement in the disease. The few studies on differential expression of genes or proteins in endometriotic MenSCs suggest that primary cell alterations are related to impaired decidualization potential and the chronic inflammatory endometrial microenvironment [ 15 , 16 , 17 , 18 ].…”