Cellular Angiofibroma: A Rare Vulvar Tumor Case Report

Fachada, Ana; Pais, Cátia Sofia Guilherme Ferreira; Fernandes, Marta Andrea Ferreira; Dias, Nuno

doi:10.1055/s-0040-1712485

Cited by 2 publications

(3 citation statements)

References 9 publications

(27 reference statements)

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“…CA is desmin positive in only a minority of cases and is consistently negative for S100 protein and keratin. [2,13]…”

Section: Discussionmentioning

confidence: 99%

“…CA is desmin positive in only a minority of cases and is consistently negative for S100 protein and keratin. [2,13] When contemplating the differential diagnoses of CA in women, there are numerous mesenchymal tumors that share close morphologic features. These include, spindle cell lipoma, solitary fibrous tumor, mammary-type myofibroblastoma, aggressive angiomyxoma (AA) and angiomyofibroblastoma.…”

Section: Discussionmentioning

confidence: 99%

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Surgical excision of giant vulvar angiofibroma: A case report and a review of literature

et al. 2022

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Rationale: Cellular angiofibroma (CA) is a rare tumor of the soft tissue classified as a benign fibroblastic/myofibroblastic tumor. Considering this, the literature regarding CA mainly, but not exclusively, comprises single case reports and case series. Here, we report a case of giant CA of the vulva with comprehensive literature review.Patient concerns: We present a case of a massive vulvar CA arising in 53-year-old woman with no notable medical or surgical history. The mass has grown considerably over time, causing pain and difficult urination, defecation, and movement. The patient had normal regular menstrual cycle with no previous contraception use. Vaginal examination exposed a right-sided large tender vulvar mass with normal-looking vagina.Diagnoses: Pelvic magnetic resonance imaging with contrast revealed a large right vulvar heterogeneously enhancing soft tissue mass measuring 13.1 × 10.9 × 10.7 cm expending the left vulva, with internal and peripheral voids resembling feeding vessels. The mass was surgically removed, and subsequent histopathology showed skin-covered dermal-based lesion composed of fibroblast-like bland and spindle cell proliferation with thin-walled blood vessels of various sizes. Immunohistostaining of CD34 and smooth muscle antigen were both positive, while desmin was found to be negative. A diagnosis of vulvar angiofibroma was made based on the clinical scenario, imaging, and histopathology.Interventions: Mass vulvectomy was performed starting with a circumferential incision at the base of the mass and structural dissection to separate the mass from the vulvar wall. The incision was successfully closed, and subcuticular stitches were applied to the skin.Outcomes: The patient's complaints were significantly relieved with no postoperative complications and the patient is being followed regularly in an outpatient setting.Lessons: Due to its extremely benign nature of CA, and the implausible ability of its recurrence, it was decided to surgically excise it. Despite its rarity, it can be readily identified at its earlier stages preventing the vexing and exasperating symptoms accompanied with increased size as mentioned.

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“…CA is desmin positive in only a minority of cases and is consistently negative for S100 protein and keratin. [2,13]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Surgical excision of giant vulvar angiofibroma: A case report and a review of literature

et al. 2022

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“…[2] Due to its low incidence, articles pertaining to vulvar CAF in the published literature largely comprise of small case series or case reports. [2][3][4][5][6][7][8][9][10][11][12][13] Owing to the non-specific clinical manifestations of CAF, preoperative diagnosis is typically challenging. Pathological examination is required to confirm the diagnosis of the disease.…”

Section: Introductionmentioning

confidence: 99%

Cellular angiofibroma of the vagina: A case report and literature review

Cai

Ye²,

Zhang

et al. 2022

Medicine

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Background: Cellular angiofibroma (CAF), a rare benign mesenchymal tumor, is histologically characterized by abundant thick-walled vessels with a spindle cell component. As one of the female reproductive system tumors, its clinical and pathological features are not well characterized. Methods: A 47-year-old woman presented for the removal of intrauterine device on October 28, 2021, as she had achieved menopause one year back. The patient had no discomfort or awareness of any mass in her vagina. She has history of breast cancer and papillary thyroid cancer. Till date, no progression of thyroid cancer or breast cancer has been observed. Her menstrual cycle was regular, and she had one child delivered vaginally. Results: Pelvic examination revealed a mass sized 2.5 × 2.0 cm located near the fornix in the upper segment of the left vaginal wall. Thin prep cytologic test (TCT) revealed negative intraepithelial lesion or malignancy (NILM). HPV test was negative and leucorrhea routine inspection cleanliness II degree. No cervical mass was detected by ultrasound examination. The patients underwent the operation for intrauterine device removal plus vaginal tumor resection on November 1, 2021. Postoperative antibiotics (intravenous cefuroxime sodium 0.75 g bid for 1 day) were administered to prevent infection. The patient showed no signs of recurrence at one-month follow-up. Conclusion: In summary, CAF is a rare benign soft tissue tumor. Surgery is the only treatment method, and the definitive diagnosis of CAF is based on histopathological examination of surgical specimen. Long-term follow-up is needed for surveillance of recurrence.

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Cellular Angiofibroma: A Rare Vulvar Tumor Case Report

Cited by 2 publications

References 9 publications

Surgical excision of giant vulvar angiofibroma: A case report and a review of literature

Surgical excision of giant vulvar angiofibroma: A case report and a review of literature

Cellular angiofibroma of the vagina: A case report and literature review

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