Validity and Reliability of the Thai Version of the Thyroid-Related Patient-Reported Outcome—A Thyroid-specific Quality of Life Questionnaire

Abstract

Introduction The Thyroid-Related Patient-Reported Outcome (ThyPRO) is a new thyroid-specific quality of life patient-reported outcome measure for benign thyroid disorders. Objective The objective of this study was to investigate the face validity, internal consistency, and test-retest reliability of the Thai version of the ThyPRO (ThyPROth). Methods The translation of the ThyPRO questionnaire was performed using double forward translation, reconciliation, single backward translation, and cognitive debriefing, followed by a panel review. Five thyroid patients evaluated the face validity. The internal consistency and test-retest reliability were evaluated in 30 patients with thyroid diseases. Results The overall validity score was 3.75 (range 0–4). The Cronbach α coefficient ranged from 0.76 to 0.95, with a total coefficient of 0.97 (95% CI 0.962–0.959), indicating excellent internal consistency. The test-retest reliability coefficient ranged from 0.70 to 0.97. All values were 0.70 and above. The total reliability coefficient was 0.86 (95% CI 0.724–0.932), indicating excellent reliability. Conclusion The ThyPROth was found to be valid and to exhibit good internal consistency and test-retest reliability. The questionnaire is ready for implementation in the assessment of health-related quality of life in Thai patients with benign thyroid diseases.

Thyroid disease‐specific quality of life questionnaires ‐ A systematic review

“…The ThyPRO was originally developed in Danish and English but has been translated and cross‐culturally validated in many other languages such as Dutch, Indian, Italian, Serbian and Swedish 21 . It has also been translated and validated in Greek, Filipino, Polish, Romanian, Spanish, Thai and German by other authors 22‐26 …”

“… 21 It has also been translated and validated in Greek, Filipino, Polish, Romanian, Spanish, Thai and German by other authors. 22 , 23 , 24 , 25 , 26 …”

Effect of Vitamin D Supplementation on Muscle Function in Patients With I131-Induced Hypothyroidism: A Pilot Randomized Trial

“…Additionally, the SF-36 questionnaire was used to assess QOL instead of the thyroid-specific patient-reported outcome (ThyPRO) questionnaire, which is specific for patients with benign thyroid diseases. Although the ThyPRO questionnaire has been translated into Thai, further research is needed to establish its construct validity by comparing responses of patients with benign thyroid diseases with those of a normal population [ 33 ]. Evidence suggested a correlation between bone mineral density and handgrip strength, as well as a strong association between bone mineral density and vitamin D levels.…”