Thalidomide Reduces Cell Proliferation in Endometriosis Experimentally Induced in Rats

Antônio, Luana Grupioni Lourenço; Silva, Júlio César Rosa e; Machado, Deborah Juliani; Westin, Andrezza Telles; Garcia, Sérgio Britto; Candido-dos-Reis, Francisco José; Poli-Neto, Omero Benedicto; Nogueira, Antônio Alberto

doi:10.1055/s-0039-3399551

Cited by 4 publications

(2 citation statements)

References 26 publications

(40 reference statements)

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“…However, further studies are needed to fully understand the molecular mechanisms that justify resistance to these drugs. Furthermore, thalidomide, a drug that acts on cell proliferation without interfering with ovarian function, has been shown to reduce the size of cysts in the retrocervical and ovarian regions, as well as decrease pelvic pain, in women with endometriosis [39].…”

Section: Therapies With Non-steroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Approach to Pain in Endometriosis Patients: Systematic Literature Review

Costa¹,

Gonçalves²,

Leite³

et al. 2022

JBM

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Background: Endometriosis is a gynecological, multifactorial condition that affects women's life quality, especially due to the pain inherent to it. Pain is caused by physical and psychological aspects; therefore, several factors must be analyzed, aiming to treat the whole. Conventional, drug or surgical treatments are the most used; however, the search for alternative therapeutic methods is growing. Objective: To analyze the approach to pain in women with endometriosis, seeking a better understanding of the pathophysiological mechanisms of this disease, its impact on life quality, as well as the means of treatments in use and innovations in this field. Methods: Systematic literature review, conducted in the Virtual Health Library databases between 2010 and 2021, restricted to articles in English and Portuguese with the descriptors: Endometriosis, Pain, and Treatment. After reading the abstracts, 197 articles were found, and, after reading them, 59 articles were selected. Results: This review analyzed 59 scientific studies that rigorously met the previously established characteristics in the sample selection. The synthesis included the following aspects: author/year of publication, article title, objective, type of study and database. Related factors such as acute or chronic pain, late diagnosis, discrediting symptomatic complaints and trivialization by health professionals have a profound impact on the physical and mental health of women with endometriosis. On the other hand, there are several classes of drugs, surgical procedures, and alternative therapies available for pain management. Conclusion: Given the context addressed, a certain need is suggested for health professionals to better understand the disease and adopt new behaviors or improve existing ones, such as reception, active listening, early diagnosis and comprehensive and individualized treatment. In addition, further studies are needed regarding alternative therapies, seeking to expand the scientific evidence of their benefits.

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Section: Therapies With Non-steroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Approach to Pain in Endometriosis Patients: Systematic Literature Review

Costa¹,

Gonçalves²,

Leite³

et al. 2022

JBM

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“…It is also observed that there is an increase in angiogenic activity in the region of the lesion, which intensifies the inflammatory effect due to the greater disposition of factors coming from the circulation. The sum of the two effects, stimulated in the long term, develops the chronic form of endometriosis, which makes treatment difficult 5 .…”

Section: Introductionmentioning

confidence: 99%

Talidomida no manejo da dor em endometriose: uma revisão de escopo de estudos experimentais

De Souza,

Lima,

Frota

et al. 2024

Rev. Cont. Saúde

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Este estudo buscou investigar a aplicabilidade da talidomida no manejo da dor na endometriose induzida em animais. Foi realizada uma revisão de escopo confeccionada e organizada seguindo o método Joanna Briggs Institute, além de seguir os padrões do PRISMA – ScR. Foram feitas pesquisas em seis bases de dados eletrônicas associando descritores e as palavras chaves, por meio de busca booleana correspondente aos blocos conceituais voltados para recuperação de estudos sobre endometriose, dor, manejo da dor e talidomida. Os países dos estudos foram: Irã (n =1, 50%) e Turquia (n = 1, 50%). Todos os artigos (n = 2; 100%) foram publicados em inglês. Quanto ao ano de publicação, observa-se que todos foram publicados nos últimos 10 anos. Nos estudos onde há comparação entre talidomida e placebo observa-se que há uma alta resposta associada com a redução de fatores inflamatórios impactando diretamente na melhora clínica dos quadros álgicos com benefícios que levam até a redução de fatores de crescimento e controle do ciclo das metaloproteinases (MPP). A busca dos estudos mostrou a atividade antiangiogênica e anti-inflamatória do fármaco, o que sugere uma opção para ser utilizada como tratamento de dor, contudo poucas literaturas estão disponíveis com talidomida.

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