‘Missing Adenocarcinomas’: Are They a Real Problem in Cervical Cancer Screening in Brazil?

Cervical Cancer Screening with HPV Testing: Updates on the Recommendation

“…9,13,16 Testing for HPV is more likely to detect adenocarcinoma precursor lesions than cytology-based screening. 6,17,18 With it, there is an increase in the proportion of adenocarcinomas detected, achieving a more efficient screening. 18,19 In high-income countries, HPV testing is cost-effective because of its higher negative predictive value combined with extended testing intervals.…”

“…6,17,18 With it, there is an increase in the proportion of adenocarcinomas detected, achieving a more efficient screening. 18,19 In high-income countries, HPV testing is cost-effective because of its higher negative predictive value combined with extended testing intervals. [20][21][22][23] In low and middleincome countries, cost-effectiveness must be addressed.…”

“…Testing for HPV is more likely to detect adenocarcinoma precursor lesions than cytology-based screening. 6 17 18 With it, there is an increase in the proportion of adenocarcinomas detected, achieving a more efficient screening. 18 19…”

“…6 17 18 With it, there is an increase in the proportion of adenocarcinomas detected, achieving a more efficient screening. 18 19…”

Label-Free Quantitative Comparison of Cervical Mucus Peptides in Subjects With Endocervical Adenocarcinoma and Adenocarcinoma in Situ

“…The ineffectiveness of glandular screening is prevalent in cytopathological diagnosis and largely restricted by sampling and interpretation. 25 Previous studies have confirmed that HPV is associated with a variety of cervical diseases, ranging from relatively benign diseases like genital warts to fatal invasive cervical cancer. To date, over 200 genotypes of HPV have been isolated and classified as high-risk (HR) and low-risk types in the light of their carcinogenicity.…”