The Algorhytm: FRAX Brazil

Albergaria, Ben Hur; Paula, Francisco José Albuquerque de

doi:10.1055/s-0039-1695027

Cited by 4 publications

(5 citation statements)

References 11 publications

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“…Foi a primeira ferramenta a fornecer um modelo de previsão de fratura específica no Brasil. Inclui oito fatores de risco clínico para estimar o risco de fratura em 10 anos: fratura anterior por fragilidade, fratura de quadris dos pais, tabagismo, uso sistêmico de glicocorticoide, ingestão excessiva de álcool, índice de massa corporal, artrite reumatoide e outras causas de osteoporose secundária; além da idade, sexo e DMO no colo do fêmur (opcional) 19 .…”

Section: Discussionunclassified

Avaliação dos fatores de risco para osteoporose e aplicação da ferramenta FRAX clínico em idoso

Neto

Cruz

Pereira

2020

Medicina (Ribeirão Preto)

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A osteoporose é caracterizada pela fragilidade óssea e mudanças em sua microarquitetura. O seu principal desfecho clínico é a fratura por baixo impacto. Uma das principais ferramentas de avaliação clínica do risco de fratura osteoporótica é o FRAX. Este trabalho objetiva avaliar os fatores de risco para osteoporose e a indicação de tratamento em idosos. Foi realizado um estudo transversal, descritivo, com abordagem quantitativa e qualitativa, por meio de um questionário, com 145 pacientes que foram atendidos no setor ambulatorial do DeCos Day Hospital, no período de novembro de 2017 a abril de 2018. Observou-se que a osteoporose prevaleceu no sexo feminino, sedentários e com idade média de 71 anos. A presença de fratura predominou na faixa etária de 70 a 79 anos e nenhum participante fazia tratamento específico para a osteoporose. Conclui-se que orientações dietéticas saudáveis são importantes como medida preventiva e a ferramenta FRAX poderia ser utilizada para estimar a probabilidade de fratura, visto que a densitometria não é a acessível a toda a população.

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Section: Discussionunclassified

Avaliação dos fatores de risco para osteoporose e aplicação da ferramenta FRAX clínico em idoso

Neto

Cruz

Pereira

2020

Medicina (Ribeirão Preto)

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“…(26) In cases of doubt regarding the indication of bone densitometry, we recommend the analysis of the FRAX-Brasil using recommendations of the National Osteoporosis Guideline Group (NOGG). (27) The FRAX-Brasil is a computerized algorithm that calculates the probability of occurrence of major osteoporotic fracture and femoral neck fracture in ten years. FRAX and NOGG used together make it possible to select patients who would benefit from performing bone densitometry.…”

Section: Screening Optionsmentioning

confidence: 99%

“…Those between the lower and upper limits must undergo bone densitometry and subsequently be reclassified according to the FRAX/NOGG. (27) FRAX-Brasil/NOGG is available for use at the following electronic address: https://abrasso.org.br/calculadora/calculadora/.…”

Section: Screening Optionsmentioning

confidence: 99%

Initial evaluation in the climacteric

Baccaro

Nasser

Valadares

et al. 2022

Rev Bras Ginecol Obstet

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“…[ 23 – 28 ] In addition, since the launch of the tool, there have been questions about the limitation of epidemiological studies that served as a database for its calibration. [ 29 ]…”

Section: Introductionmentioning

confidence: 99%

“…[23][24][25][26][27][28] In addition, since the launch of the tool, there have been questions about the limitation of epidemiological studies that served as a database for its calibration. [29] Thus, this study seeks to combine BMD and laboratory data to try and identify the best laboratory strategy for initial clinical screening based on biological profile associated with secondary osteoporosis. We aim to identify which biochemical tests are relevant to identifying patients at increased risk for secondary osteoporosis and to assess the accuracy of identifying fracture risk by FRAX and its use according to the NOGG.…”

Section: Introductionmentioning

confidence: 99%

Best Laboratory Screening in Diagnosing Secondary Osteoporosis and Fracture Risk Assessment Tool and the National Osteoporosis Guideline Group Performance in Determining Clinical Risk: A Cross-Sectional Evaluation of the Bone Health in Postmenopausal Brazilian Women

et al. 2023

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Background: Identifying postmenopausal women with a high risk of having osteoporosis and fractures is a current challenge. This study aimed to assess the diagnostic performance of biochemical tests in identifying secondary osteoporosis and the fracture risk assessment tool (FRAX) in identifying fracture risk.Methods: Data from biochemical tests and bone densitometry of postmenopausal women were analyzed. Additionally, the FRAX result was obtained and the patients were classified according to the National Osteoporosis Guideline Group (NOGG).Results: A total of 646 women were evaluated, of whom 201 (31.1%) had osteoporosis or a previous frailty fracture. These women had statistically different parathyroid hormone (PTH) and alkaline phosphatase serum levels (p<0.01 and p=0.02, respectively) than those without osteoporosis or fracture. However, those at high risk had a higher prevalence of hypovitaminosis D (46% vs. 36%) and hypocalciuria (17% vs. 9%). The FRAX showed an area under the curve of 0.757 (p<0.01) and 0.788 (p<0.01) for identifying women at risk for “major fractures” and “hip,” respectively. The NOGG categorization had a sensitivity of 19% to identify high-risk women, a specificity of 91.3% for low-risk women, with a positive predictive value of 57.4% and a negative predictive value of 64.6%.Conclusions: The evaluation of PTH, 25-hydroxy-vitamin D, serum calcium, and 24-hr urinary calcium proved adequate for initial osteoporosis screening. The FRAX tool has a regular ability to screen women at risk for fracture, and the NOGG method has high specificity to identify those at low risk.

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The Algorhytm: FRAX Brazil

Cited by 4 publications

References 11 publications

Avaliação dos fatores de risco para osteoporose e aplicação da ferramenta FRAX clínico em idoso

Avaliação dos fatores de risco para osteoporose e aplicação da ferramenta FRAX clínico em idoso

Initial evaluation in the climacteric

Best Laboratory Screening in Diagnosing Secondary Osteoporosis and Fracture Risk Assessment Tool and the National Osteoporosis Guideline Group Performance in Determining Clinical Risk: A Cross-Sectional Evaluation of the Bone Health in Postmenopausal Brazilian Women

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