The Influence of Dietary Salt on the Osseointegration of Implants in Aging Rats

Abstract

Introduction The bone-implant interface has been studied extensively, but only few papers focused on the nutritional aspects that may affect bone quality, especially salt intake. Objective To study the osseointegration of implants in salt-loaded rats with low mineral bone content. Methods A total of 60 4-month-old male rats were divided in 2 groups ( n = 30), being these groups divided in 2 periods, (2 and 4 months). The control group received a normal diet, while the test group received a diet supplemented with 1% sodium chloride (NaCl). Implants were placed in the tibia of both groups. A total of 15 animals of each group were sacrificed at the 2 nd month of the experiment, while the remaining animals were sacrificed at the 4 th month. Results No statistically significant difference was found in food intake between the groups on any experimental period, but a statistically significant difference was found in the liquid intake in the saline group in both periods. For all groups, osseointegration was observed in both groups. The mean percentage of osseointegration in the cortical bone, in the trabecular bone, and in the total osseointegrated surface between the control (46.38 ± 16.17%) and saline (49.13 ± 11.52%) groups at 2 months was not statistically different ( p = 0.61). The total osseointegration areas of the control (53.98 ± 12.06%) and saline (51.40 ± 13.01%) groups at the 4 th month of the study were not statistically ( p = 0.61). Conclusion Ingestion of salt did not affect directly the osseointegration process during the period of the experiment. The results suggest that mineral losses may not affect the achievement of good osseointegration in aging rats.

The Protective Effect of Zinc on Salt Induced Histological Changes in Femur of Sprague Dawley Rats-Data Driven Approach

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Adult Swallowing Disorders: Focus on Quality of Life

“…An experimental study 7 on salt intake and mineral loss published in this journal (2019) reported that mineral loss caused by salt intake did not directly affect the quality of bone healing after analyzing the influence of diet on osseointegration of dental implants in the elderly rats. Even with the lowest bone mineral density, the authors concluded that mineral loss did not interfere with osteointegration immediately after aging.…”

“…Even with the lowest bone mineral density, the authors concluded that mineral loss did not interfere with osteointegration immediately after aging. 7…”