Anatomical Variations in Patients with Ménière Disease: A Tomography Study

Abstract

Introduction The etiology of Ménière disease (MD), a difficult-to-treat condition with great morbidity, remains controversial in the literature. The possible clinical and diagnostic impact of anatomical variations of the temporal bone among patients with MD has been recently studied. Objective To identify anatomical variations of the temporal bone associated with the diagnosis of MD. Methods Thirty-seven patients were included, although each ear was considered separately ( n = 74). A case group ( n A = 33) was composed of the affected ears of patients with definite MD and a control group ( n B = 41) was used consisting of the ears of individuals who did not meet the criteria for MD and of the contralateral ears from patients with unilateral disease. Tomographic images from the individuals included in the study were submitted to a blinded and systematic evaluation regarding a broad variety of anatomical variations of the temporal bone. Obtained data were compared statistically between the groups and after stratifying the study sample. Significance level was set at 0.05. Results Among the affected ears, it was observed an increased number of tomographic scans in which the vestibular aqueduct could not be identified ( p = 0.01, Fisher exact test). No statistically significant differences were observed when comparing the affected and contralateral ears from patients with unilateral MD, between affected ears from patients with unilateral and bilateral disease or between contralateral ears of patients with unilateral affection and patients without the disease. Conclusion Some anatomical variations might be more frequent in the affected ears of patients with MD, such as the lower rates of individualization of the vestibular aqueduct.

Population-based study for the comorbidities and associated factors in Ménière’s disease

“…MD is a complex heterogeneous disorder, with multiple factors reported to contribute to its development, 4 including age (older than 60 years), sex (female) 2 , 3 , genetics 5 , 6 , race (white people) 7 , stature and leg length (short) 8 , metabolic disorder 9 , 10 , autoimmunity 10 – 17 , anatomy 18 , allergies 19 , migraines 20 , weather (high humidity and low atmospheric pressure) 21 , diets, and stress 22 . However, the majority of studies are limited by a lack of population-based cohorts and low number of cases; therefore, the underlying disease pathological pathways remain unclear.…”

Value of CT and three-dimensional reconstruction revealing specific radiological signs for screening causative high jugular bulb in patients with Menière's disease

“…Redfern et al and Park et al have described a higher prevalence of JB abnormalities in patients with MD, as compared with the general population (11,18). However, numerous studies have reported no difference in the prevalence of HJB between affected and unaffected ears (19,20). In the present study, the Manjila and Semaan classi cation was used to divide JBs into types1 (Fig.…”

Meniere’s Disease: The Current State of the Problem

“…На сегодняшний день существует несколько теорий развития БМ [40]. Анатомическая теория подразумевает аномалии в строении височной кости, в частности пониженную пневматизацию клеток сосцевидного отростка и гипоплазию вестибулярного водопровода, в котором залегает эндолимфатический проток, при этом малых размеров эндолимфатический мешок неправильно расположен позади лабиринта, что способствует развитию ЭГ [29].…”