Sudden Sensorioneural Hearing Loss and Autoimmune Systemic Diseases

Rossini, Bruno Almeida Antunes; Penido, Norma de Oliveira; Munhoz, Mário Sérgio Lei; Bogaz, Eduardo Amaro; Curi, Renata Souza

doi:10.1055/s-0036-1586162

Cited by 53 publications

(65 citation statements)

References 52 publications

(61 reference statements)

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“…The most important audiological test battery in all cases should include PTA possibly extended to the high-frequency region, TEOAE and DPOAE, and ABR [5, 129]. Vestibular testing should include a basic vestibular exam integrated with caloric test, video head impulse test, and VEMPs [129].…”

Section: Inner Ear Involvement In Autoimmune Diseasesmentioning

confidence: 99%

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Ralli

D’Aguanno

Stadio

et al. 2018

Journal of Immunology Research

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Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss is the most common audiovestibular symptom associated with systemic autoimmune diseases, although conductive hearing impairment may also be present. Hearing loss may present in a sudden, slowly, rapidly progressive or fluctuating form, and is mostly bilateral and asymmetric. Hearing loss shows a good response to corticosteroid therapy that may lead to near-complete hearing restoration. Vestibular symptoms, tinnitus, and aural fullness can be found in patients with systemic autoimmune diseases; they often mimic primary inner ear disorders such as Menière's disease and mainly affect both ears simultaneously. Awareness of inner ear involvement in systemic autoimmune diseases is essential for the good response shown to appropriate treatment. However, it is often misdiagnosed due to variable clinical presentation, limited knowledge, sparse evidence, and lack of specific diagnostic tests. The aim of this review is to analyse available evidence, often only reported in the form of case reports due to the rarity of some of these conditions, of the different clinical presentations of audiological and vestibular symptoms in systemic autoimmune diseases.

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Section: Inner Ear Involvement In Autoimmune Diseasesmentioning

confidence: 99%

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Ralli

D’Aguanno

Stadio

et al. 2018

Journal of Immunology Research

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“…9,10 Many published studies have demonstrated that systemic autoimmune diseases are risk factors for onset of SSNHL, a recent population-based research showed that patients with immune-mediated disease had a 4.27-fold increased the risk of SSNHL than those in the control group. 11 Similarly, Lee et al 12 found that patients with RA had a higher risk of suffering SSNHL compared with those without RA. However, few research studies have evaluated the effect of comorbid systemic autoimmune diseases on the prognosis of SSNHL.…”

Section: Introductionmentioning

confidence: 97%

Effect of systemic lupus erythematosus and rheumatoid arthritis on sudden sensorineural hearing loss

Xie

Ning

She³

et al. 2019

The Laryngoscope

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Objectives Recent reports have identified autoimmune systemic diseases as a significant risk factor for sudden sensorineural hearing loss (SSNHL). We investigated whether systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) were correlated with the hearing recovery of SSNHL. Study Design A retrospective study. Methods Records of 663 SSNHL patients between January 2008 and January 2019 were retrospectively reviewed, including demographic, comorbid diseases, and hearing recovery. Patients were divided into four groups (complete, partial, slight, and no recovery) according to Siegel's criteria and Chinese Medical Association of Otolaryngology (CMAO) criteria. Multinomial logistic regression was performed to evaluate the effects of onset of treatment, initial hearing threshold, audiogram pattern, diabetes mellitus, SLE, and RA on the prognosis of SSNHL according to both criteria. Results Patients in complete recovery, partial recovery, slight recovery, and no improvement were 95 (14.3%), 183 (27.6%), 170 (25.6%), and 215 (32.4%) by Siegel's criteria, and 90 (13.6%), 152 (22.9%), 188 (28.4%), and 233 (35.1%) by CMAO criteria, respectively. Among the four groups, onset of treatment, initial hearing threshold, diabetes mellitus, SLE, RA, and profound audiogram pattern were found to be associated with recovery outcome by both Siegel's criteria and CMAO criteria (P < .05). According to analysis results, presence of SLE, RA, diabetes mellitus and higher initial hearing threshold were significantly correlated with a poor prognosis by both Siegel's criteria and CMAO criteria (P < .05). Conclusion Comorbid SLE or RA may negatively affect the prognosis of SSNHL. Lower initial hearing threshold and absence of diabetes mellitus are associated with favorable hearing recovery. Level of Evidence 4. Laryngoscope, 130:2475–2480, 2020

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“…For many years, autoimmunity has been accused of sudden hearing loss. In recent years, however, there has been a growing interest in studies involving internal ear involvement secondary to systemic autoimmune diseases 5 . In recent years, studies evaluating hearing have also been performed in patients with psoriasis 6‐10 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of audiovestibular system in psoriasis patients without joint involvement

Ertuğrul

Söylemez

2020

Dermatologic Therapy

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Inner ear involvement may occur in systemic autoimmune diseases. Although there are studies evaluating hearing in psoriasis patients, its effect on the balance system is not clear. The aim of the present study was to evaluate the audiovestibular system in psoriasis patients without joint involvement. In this prospective study, the audiovestibular system of 32 psoriasis patients without joint involvement and 35 healthy volunteers were evaluated. The severity of the disease was determined by the psoriasis area severity index (PASI). There was no significant difference between the groups in terms of hearing test results, while the abnormal caloric test response was significantly higher in the psoriatic patients. PASI scores of psoriasis patients with abnormal caloric test results were higher than those with normal caloric test response. In psoriasis patients without joint involvement, the hearing was not affected, but the vestibular system was. The severity of the disease was associated with vestibular involvement. Particularly in patients with severe psoriasis, it must be considered that the vestibular system might be affected, and vestibular evaluations should be performed.

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Sudden Sensorioneural Hearing Loss and Autoimmune Systemic Diseases

Cited by 53 publications

References 52 publications

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Effect of systemic lupus erythematosus and rheumatoid arthritis on sudden sensorineural hearing loss

Evaluation of audiovestibular system in psoriasis patients without joint involvement

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