Comparison of Classical and Secondary Cytologic Criteria Relative to Hybrid Capture for Diagnosing Cervical-vaginal Infection by Human Papillomavirus

Etchebehere, Renata Margarida; Almeida, Elia Cláudia Souza; Côbo, Eliângela Castro; Duque, Ana Cristina da Rocha; Murta, Eddie Fernando Cândido; Adad, Sheila Jorge

doi:10.1055/s-0035-1570105

Cited by 3 publications

(2 citation statements)

References 21 publications

(37 reference statements)

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“…Among the theories that justify this data, it is said that, during the gestational period, the body of the woman goes through hormonal changes and transitory immunocompetent depression. 7 In addition, during this period, there are higher rates of viral replication, especially on the second half of the gestational period, increasing the risk of mother-to-child transmission, or vertical transmission (VT). 2 Vertical transmission may occur during the intrauterine life via transplacental transmission, or on the moment of the passage of the fetus through the birth canal due to the direct contact with the infected genital tract.…”

Section: Introductionmentioning

confidence: 99%

Knowledge of Pregnant Adolescents about Human Papillomavirus

Tanaka

Kamizaki

Quintana

et al. 2019

Rev Bras Ginecol Obstet

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Objective To evaluate the level of information possessed by pregnant adolescents regarding the human papillomavirus (HPV). Methods Descriptive study developed in the adolescent prenatal outpatient clinic of a tertiary hospital from the state of São Paulo, Brazil. Data were collected between June and December 2017 following approval from the ethics and research committee (CAAE: 1.887.892/2017). Pregnant adolescents, ≤18 years old, who attended the abovementioned outpatient section, composed the sample. Those diagnosed with a psychiatric disorder and those with hearing or cognitive disabilities were excluded. After acceptance to participate in the present study, the pregnant adolescents signed an Informed Consent Form. Regarding the statistical analysis, the chi-squared test and the Fisher exact test were used. Results Regarding the knowledge about HPV, 123 (80.92%) of the participants had already heard about the subject; for 77 (50.66%), their schools had been the source of the information; 101 (66.45%) did not know how they could be infected by the virus. Age variation did not influence their knowledge on how to prevent themselves from HPV (p = 0.2562). The variable vaccine is associated with HPV prevention (p < 0.0001). Conclusion The pregnant adolescents composing the sample have shown to have knowledge about HPV. However, they do not prevent themselves from it appropriately, given that little more than half of the sample was vaccinated, had not reported an understanding that the use of preservatives and vaccination are effective means of prevention, and did not correlate HPV with uterine cervical cancer.

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Section: Introductionmentioning

confidence: 99%

Knowledge of Pregnant Adolescents about Human Papillomavirus

Tanaka

Kamizaki

Quintana

et al. 2019

Rev Bras Ginecol Obstet

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“…Koilocytosis and dyskeratosis are pathognomonic of HPV infection, but various studies suggest that the inclusion of alternative cytomorphological signals increases sensitivity of cytology over PCR for the detection of HPV [30, 31]. Here we have shown that parakeratosis, corneal pearl, giant cell and bi/multinucleation findings were more frequent in the ASC-US group, with a statistically significant difference in relation to the other group.…”

Section: Discussionmentioning

confidence: 49%

Atypical Squamous Cells: Cytopathological Findings and Correlation with HPV Genotype and Histopathology

Oliveira

Eleutério

et al. 2018

Acta Cytologica

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Objective: We aimed to assess potential associations between atypical squamous cell (ASC) subgroups: ASC-US (undetermined significance) and ASC-H (cannot exclude high-grade squamous intraepithelial lesion), regarding cytomorphological features, high-risk (HR) human papillomavirus (HPV) testing, and histological outcomes in a sample of Brazilian women. Study Design: Cross-sectional study which evaluated 1,346 liquid-based cytologies between January 2010 and July 2016 with ASC results. ASC-US and ASC-H were analyzed for frequency, diagnostic criteria, and cytological findings and compared with HR-HPV tests and histological outcomes. Results: Enlarged nucleus was the most frequent ASC-US criterion, but alternative criteria were present in 20% of the total cases. No ASC-US criteria were associated with histological outcomes or HR-HPV positivity. Parakeratosis, corneal pearl, giant cells, and binucleation were strongly associated with ASC-US while hyperkeratosis was associated with high-grade squamous intraepithelial lesions (HSIL) or a superior outcome. HR-HPV was positive in 64.39% of ASC-US and 65.38% of ASC-H. HSIL or superior outcomes also occurred in 13.33% of ASC-US and 64.71% of ASC-H cases. Conclusion: Alternative criteria for ASC-US were relatively frequent. Reactive cellular changes suggestive of atypias were more abundant in ASC-US. Although ASC-H is associated with worse histological outcomes, no differences in HPV positivity were found in comparison to ASC-US.

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Retrospective analysis of cervical cancer and precancerous lesions in patients with atypical squamous cells of undetermined significance in China

et al. 2019

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Atypical squamous cells of undetermined significance (ASCUS) are the most common cytological abnormality of all smear test. No study has demonstrated the prevalence of cervical cancer or its precursor in Chinese patients with ASCUS. This study aims to investigate the prevalence of cervical intraepithelial neoplasia 1 or worse (CIN1+) and CIN3 or worse (CIN3+) in patients with ASCUS in China to provide insight into appropriate management for Chinese health care. In a retrospective cross-sectional study, patients who underwent liquid-based thin layer cytology and human papillomavirus (HPV) co-testing at the Peking Union Medical College Hospital between January 2014 and January 2017, and had ASCUS results on liquid-based thin layer cytology test and underwent follow-up and colposcopic biopsy were included. Age, HPV DNA test, and pathological outcomes were assessed. One hundred forty-four patients with ASCUS and positive HPV test results were included. In the 3-year follow-up, 23 (16.0%) patients had CIN1, 28 (19.4%) had CIN2, and 17 (11.8%) had CIN3 or carcinoma in situ. The risk of CIN3+ was significantly higher in those older than 60 years (42.8%, P = .005), whereas the CIN1+ prevalence displayed no significant difference between age groups. Both hybrid Capture II (HC II) value and cytopathological description of HPV infection showed no statistically significant correlation with CIN1+ or CIN3+. Patients with HPV-positive ASCUS who were older than 60 years had a significantly higher risk of CIN3+, and clinicians should pay more attention to them. Both HC II value and cytopathological description of HPV infection showed no significant correlation with CIN1+ or CIN3+.

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Comparison of Classical and Secondary Cytologic Criteria Relative to Hybrid Capture for Diagnosing Cervical-vaginal Infection by Human Papillomavirus

Cited by 3 publications

References 21 publications

Knowledge of Pregnant Adolescents about Human Papillomavirus

Knowledge of Pregnant Adolescents about Human Papillomavirus

Atypical Squamous Cells: Cytopathological Findings and Correlation with HPV Genotype and Histopathology

Retrospective analysis of cervical cancer and precancerous lesions in patients with atypical squamous cells of undetermined significance in China

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