Abstract:Introduction Isolated disease of the sphenoid is rare and has often been overlooked due to its remote location and difficult access.
Objective A retrospective study of the main causes of isolated sphenoid sinus diseases with discussion of the most appropriate methods of diagnosis and treatment.
Methods A total of 46 cases of isolated sphenoid disease treated between January 2008 and December 2013 were evaluated by objective ear, nose, and throat examination and video endoscopy, computed tomography of the paran… Show more
“…The most common lesion in this group was bacterial sphenoiditis in the majority of studies [ 1 , 3 , 4 , 7 – 11 , 13 – 20 , 22 ]. There are four studies that show different results: a mucocele in two studies [ 12 , 21 ], fungal infection in the study by Castelnuovo et al [ 5 ], and a polyp in the study by Celenk et al [ 6 ]. Tumor was the second most common; fibroosseous lesions were included in this group in many studies, though some grouped them into the miscellaneous category [ 24 ].…”
Objective To review and report diseases of the sphenoid sinus from the literature and from a university hospital. Methods Inpatients' data were retrospectively gathered and reviewed from January 2006 to June 2016. Clinical data, imaging, organisms, and pathological reports were collected. Pathology was divided into infection/inflammation, tumor, and miscellaneous. A literature review was performed with the search term “isolated sphenoid disease” in PubMed. Original primary studies with 20 patients or more were reviewed. Results and Discussion One hundred and twenty-two patients were enrolled. Seventy-two subjects were female (59%). The average age was 54.3 years (±18.0). Imaging abnormalities were found incidentally in 27 patients (22.1%). The most common symptom was headache (63.9%). Visual loss, the second most common symptom, was more frequent in the tumor group (30.6% versus 54.2%). From the literature review, 21 primary studies with 1,320 total patients were included. From all studies and the present study, infection/inflammation was the most common pathology (75%) [95% confidence interval (CI): 0.696, 0.804]. Overall, tumors were found in 18.9% and malignant tumors in 7.0% [95% CI: 0.045, 0.095]. Conclusion A specific diagnosis of a sphenoid lesion is needed during active investigation. Infection/inflammation was the most common pathology and malignancy was found in 7%.
“…The most common lesion in this group was bacterial sphenoiditis in the majority of studies [ 1 , 3 , 4 , 7 – 11 , 13 – 20 , 22 ]. There are four studies that show different results: a mucocele in two studies [ 12 , 21 ], fungal infection in the study by Castelnuovo et al [ 5 ], and a polyp in the study by Celenk et al [ 6 ]. Tumor was the second most common; fibroosseous lesions were included in this group in many studies, though some grouped them into the miscellaneous category [ 24 ].…”
Objective To review and report diseases of the sphenoid sinus from the literature and from a university hospital. Methods Inpatients' data were retrospectively gathered and reviewed from January 2006 to June 2016. Clinical data, imaging, organisms, and pathological reports were collected. Pathology was divided into infection/inflammation, tumor, and miscellaneous. A literature review was performed with the search term “isolated sphenoid disease” in PubMed. Original primary studies with 20 patients or more were reviewed. Results and Discussion One hundred and twenty-two patients were enrolled. Seventy-two subjects were female (59%). The average age was 54.3 years (±18.0). Imaging abnormalities were found incidentally in 27 patients (22.1%). The most common symptom was headache (63.9%). Visual loss, the second most common symptom, was more frequent in the tumor group (30.6% versus 54.2%). From the literature review, 21 primary studies with 1,320 total patients were included. From all studies and the present study, infection/inflammation was the most common pathology (75%) [95% confidence interval (CI): 0.696, 0.804]. Overall, tumors were found in 18.9% and malignant tumors in 7.0% [95% CI: 0.045, 0.095]. Conclusion A specific diagnosis of a sphenoid lesion is needed during active investigation. Infection/inflammation was the most common pathology and malignancy was found in 7%.
“…Mean time to recurrence was 15 months (8–26 months). Recurrence rate of inflammatory sphenoid sinus disease varies greatly in the literature, ranging from 0 to 20.8% [ 1 , 8 , 14 , 15 , 22 , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] ]. Many authors have reported a high percentage of recurrences and reossification of the surgically opened sphenoid ostium.…”
Section: Discussionmentioning
confidence: 99%
“…This study is particularly relevant because it demonstrates the refractory character of inflammatory pathologies of the sphenoid sinus, with some patient requiring surgical intervention on 3 different occasions for recurrent sphenoid disease. However, many groups have presented series of patients with surgically treated isolated sphenoidal sinusitis for which recurrence rates were much smaller or even null [ 1 , [26] , [27] , [28] , [29] , [30] , [31] , [32] ]. One of the reasons that may explain the difference between these low reported recurrence rates is the duration of follow-up.…”
Section: Discussionmentioning
confidence: 99%
“…Isolated sphenoid opacification is a rare pathology that is increasingly being described in the literature. Isolated sphenoid sinusitis represents 1–2% of sinus infections [ 1 ]. The sphenoid sinus is at the center of important structures: the dura mater, the pituitary gland, the cavernous sinus, the internal carotid as well as cranial nerves II, III, IV, V and VI [ 2 ].…”
Sphenoid sinus malignancies are rare, with high prevalence in white males. The most common histopathology is squamous cell neoplasms. They exhibit significant locoregional extension. Of the common sphenoid sinus malignant subtypes, 5-year DSS is best for mature B-cell NHL and worst for unspecified epithelial neoplasms.
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