Language in Children with Neonatal Hypoxic-Ischemic Encephalopathy

Martinez, Chenia Caldeira; Carneiro, Luciana S.; Vernier, Luíza Silva; Cesa, Carla Ciceri; Guardiola, Ana; Vidor, Deisi Cristina Gollo Marques

doi:10.1055/s-0034-1366976

Cited by 10 publications

(1 citation statement)

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“…Previous studies of developmental outcome following HI have documented a range of cognitive deficits, including in the domains of memory (Cooper et al, 2015;Gadian et al, 2000;Muñoz-López et al, 2017), language (Hövels-Gürich et al, 2002;Martinez et al, 2014;Robertson and Finer, 1985), and attainment (Hövels-Gürich et al, 2002;Marlow et al, 2005), though not necessarily simultaneously. Here we provide evidence that HI of cardiorespiratory origin can lead to impairments in all three domains.…”

Section: Cognitive Impairments and Brain Abnormalitiesmentioning

confidence: 99%

Cognitive outcome and its neural correlates after cardiorespiratory arrest in childhood

Geva

Hoskote

Saini

et al. 2023

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Hypoxia-ischaemia (HI) can result in structural brain abnormalities, which in turn can lead to behavioural deficits in various cognitive and motor domains, in both adult and paediatric populations. Cardiorespiratory arrest (CA) is a major cause of hypoxia-ischaemia in adults, but it is relatively rare in infants and children. While the effects of adult CA on brain and cognition have been widely studied, to date, there are no studies examining the neurodevelopmental outcome of children who suffered CA early in life. Here, we studied the long-term outcome of 28 children who suffered CA during infancy or childhood (i.e., before age 16). They were compared to a group of control participants (n = 28) matched for age, gender and socio-economic status. The patient group had impairments in the domains of memory, language and academic attainment (measured using standardised tests; impairment defined as a score > 1.5 standard deviations below the control group mean). Individual scores within the impaired range were most commonly found within the memory domain (79%), followed by attainment (50%), and language (36%). The patient group also had reduced whole brain grey matter volume, and reduced volume and fractional anisotropy of the white matter. In addition, lower performance on memory tests was correlated with bilaterally reduced volume of the hippocampi, thalami, and striatum, while lower attainment scores were correlated with bilateral reduction of fractional anisotropy in the superior cerebellar peduncle, the main output tract of the cerebellum. We conclude that patients who suffered early CA are at risk of developing specific cognitive deficits associated with structural brain abnormalities.

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