Magnetic Mesoporous Silica Gated with Doped Carbon Dot for Site-Specific Drug Delivery, Fluorescence, and MR Imaging

Abstract

Construction of a theranostic agent which integrates multiple modalities with different functions into one entity is challenging from a molecular design and synthesis perspective. In this context, the present paper reports the fabrication of a novel type of multifunctional hybrid nanoparticle composed of magnetic gadolinium oxide-iron oxide core, mesoporous silica shell gated with boronic acid functionalized highly luminescent carbon quantum dot (BNSCQD). The porous silica shell acts as an excellent reservoir for anticancer drug 5-fluorouracil, whereas the BNSCQD cap impressively controls the drug transport under simulated intracellular environment. Furthermore, recognition and fluorescence turn on response of BNSCQD toward cell surface glycan sialyl Lewis (SL) enables targeted drug release and excellent fluorescence imaging of SL overexpressed HePG2 cancer cells. The r and r relaxivities of the material are found to be 10 and 165 mM s which is comparable to commercially available magnetic resonance imaging contrast agents. Benefiting from the combined advantages of dual stimuli-responsive drug release, excellent optical imaging, and MR imaging, this novel construct can be a promising theranostic material.

Carbon quantum dots and their biomedical and therapeutic applications: a review

“…183 The CQDs have been used in multifunctional platforms for drug delivery and magnetic delivery and/or MRI agents and/or simultaneous co-delivery of two or more drugs, including multi-functional DDS of CQDs and DOX and heparin as an auxiliary medicine for delivery to the A549 cells, Fe 3 O 4 @CQDs coated single-walled carbon nanotubes loaded with DOX and conjugated with an sgc8c aptamer as a platform for combining cancer photothermal therapy, chemotherapy, and photodynamic therapy, 185 and magnetic gadolinium oxide-iron oxide core, mesoporous silica shell gated with boronic acid functionalized CQDs for drug delivery of anticancer drug 5-uorouracil to HePG2 cancer cells which the platform acts as MRI agent and optical imaging agent as well as stimuli-responsive DDS. 186…”

Clustering of Iron Oxide Nanoparticles with Amphiphilic Invertible Polymer Enhances Uptake and Release of Drugs and MRI Properties

“…Because NPCs reported here are easily magnetically separable, they can be promising for magnetic drug delivery. At the same time, it is beneficial for such drug delivery vehicles to show a strong MRI signal to allow for MRI guided drug delivery, i.e., theranostic bioprobes . To evaluate the MRI properties of NPCs, MR relaxivities and map images of the NPCs isolated by MS or UC were examined.…”

“…At the same time, it is beneficial for such drug delivery vehicles to show a strong MRI signal to allow for MRI guided drug delivery, i.e., theranostic bioprobes. [75,76] To evaluate the MRI properties of NPCs, MR relaxivities and map images of the NPCs isolated by MS or UC were examined. Experiments were performed in a clinical 3T MR scanner at room temperature.…”

<p>A review of small molecules and drug delivery applications using gold and iron nanoparticles</p>

“…A drug release experiment under various pH values and in the presence of the competitive binding ligand SLa clearly showed excellent responsiveness of the BNSCQD-capped MSN hybrid system toward dual stimuli. 103 In another study, Egodawatte et al evaluated three different solvents (dimethyl sulfoxide, water, and water/acetone) for loading of 5-FU into magnetic IO/mesoporous silica nanocomposites (m-MCM-41) with and without functionalization of aminopropyl. Their findings showed that the 5-FU loading and release characteristics from m-MCM-41 depended on the polarity of the solvent and the surface functionalization of the host.…”