Vitamin e kinetics and the function of tocopherol regulatory proteins

Blatt, David H.; Leonard, Scott W.; Traber, Maret G.

doi:10.1016/s0899-9007(01)00637-2

Cited by 111 publications

(64 citation statements)

References 88 publications

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“…However, a possible cause of the limitation on plasma atocopherol concentrations could be the redistribution of plasma a-tocopherol into tissues, particularly into adipose tissue. Tissue a-tocopherol concentrations probably depend on tocopherol regulatory protein function and tissue lipid content, vitamin E uptake and efflux, oxidative stress, and interactions between vitamin E and other antioxidants (Blatt et al, 2001). …”

Section: Discussionmentioning

confidence: 99%

“…Tissue vitamin E concentrations might equilibrate more rapidly in tissues with greater vitamin E uptake, as well as with increased amounts or activity of tocopherol regulatory protein (TRP) (Blatt et al, 2001). The vitamin E uptake from plasma by lymphocytes still remains unknown, but recently the expression of a-tocopherol transfer protein (a-TTP) in leucocytes has been reported (Misaki et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

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Differential response of plasma and immune cell's vitamin E levels to physical activity and antioxidant vitamin supplementation

et al. 2005

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Objective: To assess the differential response of plasma, lymphocyte and neutrophil vitamin E levels to high-intensity physical activity and to vitamin C and E supplementation. Subjects: In all, 14 male trained amateur runners (32-36 y old) were randomly divided in two groups (supplemented and placebo), and participated in a half marathon race. The subjects did not take any other supplements than the ones provided for this study. Intervention: Vitamin C (152 mg/day) and E (50 mg/day) supplementation was administrated to athletes for a month, using a new almond-based isotonic and energetic beverage (supplemented group). The usual dietary habits of participants were assessed using a self-reported 7-day 24-h recall before the day of the study. To avoid the beverage influence, nonenriched vitamin C and E almond-based isotonic and energetic beverage was given to the placebo group. After 1 month, subjects participated in a half marathon race (21 km run). Vitamin E concentration was determined in plasma, neutrophils and lymphocytes before and immediately after the race, and 3 h after finishing the race. Results: Daily energy intake and caloric profile of supplemented and placebo group were not different except for vitamin C and E supplementation. Vitamin supplementation and exercise had no effect on vitamins E levels in plasma. The exercise significantly (Po0.05) increased the lymphocyte vitamin E concentration both in the placebo ( þ 119%) and supplemented groups ( þ 128%), and neutrophil vitamin E content in the supplemented group ( þ 88%). These levels remained significantly (Po0.05) high after the short recovery. After exercise, vitamin E levels in lymphocytes and neutrophils of supplemented subjects were practically twice the levels before exercise, whereas neutrophil vitamin E content of the placebo group was close to those in plasma. Conclusion: After endurance exercise, lymphocytes increased their vitamin E content in the supplemented and placebo subjects whereas this trend in neutrophils was just observed in the supplemented group. The determination of vitamin E content in lymphocytes and neutrophils after exercise is a useful tool to assess the functional status of vitamin E.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Differential response of plasma and immune cell's vitamin E levels to physical activity and antioxidant vitamin supplementation

et al. 2005

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“…1), and this form possesses the highest biological activity in humans; in this form, VE is best absorbed by the gastrointestinal tract. For this reason, the term α-tocopherol is frequently referred to as vitamin E [7][8][9][10]. The antioxidant capacity of VE resides in transferring a phenolic H + to oxidant radicals derived from oxidized polyunsaturated fatty acids; this antioxidant activity is independent of enzymatic processes [7,10,11].…”

Section: Vitamin Ementioning

confidence: 99%

“…For this reason, the term α-tocopherol is frequently referred to as vitamin E [7][8][9][10]. The antioxidant capacity of VE resides in transferring a phenolic H + to oxidant radicals derived from oxidized polyunsaturated fatty acids; this antioxidant activity is independent of enzymatic processes [7,10,11]. Therefore, VE provides a "first line of defence" against DNA oxidative damage and lipid peroxidation of unsaturated fatty acids in the cell membrane [10,11].…”

Section: Vitamin Ementioning

confidence: 99%

“…The antioxidant capacity of VE resides in transferring a phenolic H + to oxidant radicals derived from oxidized polyunsaturated fatty acids; this antioxidant activity is independent of enzymatic processes [7,10,11]. Therefore, VE provides a "first line of defence" against DNA oxidative damage and lipid peroxidation of unsaturated fatty acids in the cell membrane [10,11]. After VE supplementation has been observed an increase in intracellular concentrations of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPX), but the mechanisms of this VE-mediated effects are still not fully understood [12,13].…”

Section: Vitamin Ementioning

confidence: 99%

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Therapeutic perspectives on the combination of α-lipoic acid and vitamin E

González-Pérez

González-Castañeda

2006

Nutrition Research

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Alpha-lipoic acid and vitamin E have synergistic effects, as determined in models of oxidant radical lesions. This review summarizes recent findings showing that the combination of alpha-lipoic acid plus vitamin E has beneficial effects in reducing oxidative damage in ischemic or other oxidationrelated pathological events. Both antioxidants are common in the normal human diet and side effects are very rare. Therefore, alpha-lipoic acid and vitamin E can counteract oxidative processes and could have an important role in clinical medicine.

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Passages: 2006

Saper¹

2005

J. Comp. Neurol.

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Vitamin e kinetics and the function of tocopherol regulatory proteins

Cited by 111 publications

References 88 publications

Differential response of plasma and immune cell's vitamin E levels to physical activity and antioxidant vitamin supplementation

Differential response of plasma and immune cell's vitamin E levels to physical activity and antioxidant vitamin supplementation

Therapeutic perspectives on the combination of α-lipoic acid and vitamin E

Passages: 2006

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