Cadmium exerts toxic effects on ovarian steroid hormone release in rats

Zhang, Wenchang; Pang, Fen; Huang, Yaqing; Yan, Ping; Lin, Wei

doi:10.1016/j.toxlet.2008.07.016

Cited by 70 publications

(22 citation statements)

References 9 publications

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“…Over the past decade, environmental levels of Cd have consistently increased, and mammals are very susceptible to the action of this metal (Zhang et al, 2008). Non-occupational exposure is mainly from diet and smoking (Satarug and Moore, 2004).…”

Section: Discussionmentioning

confidence: 99%

Cadmium inhibits the ovary δ‐aminolevulinate dehydratase activity in vitro and ex vivo: protective role of seleno‐furanoside

Vargas

Soares

Izaguirry

et al. 2012

J of Applied Toxicology

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Cadmium (Cd) toxicity is a concern to the tobacco-smoking sub-population which includes millions of people worldwide. Although this metal may cause severe damage to embryos and the reproductive organs, the precise mechanisms underlying its toxicity remain unclear. In the present study, the Cd effect on ovary δ-aminolevulinate dehydratase (δ-ALA-D) activity was investigated in vitro and ex vivo. We observed that low concentrations of Cd inhibited cow ovary δ-ALA-D activity in vitro and the IC50 value obtained was 19.17 μM. Furthermore, the protective effect of a novel organic selenium compound (seleno-furanoside) in restoring enzyme activity was evaluated. Seleno-furanoside (10, 50, 100, 200, 400 and 1000 μM) did not reverse the Cd toxicity in bovine ovarian tissue in vitro. According to the in vitro reults, acute Cd exposure (2.5 and 5 mg kg(-1)) caused a significant inhibition in ovary δ-ALA-D activity in mice (around 27% and 34%, respectively). Therapy with seleno-furanoside (100 µmol kg(-1)) was able to restore enzyme activity. Thus, we demonstrated for the first time that δ-ALA-D activity from ovary is inhibited by Cd both in vitro and ex vivo. Additionally, seleno-furanoside therapy was effective in restoring ovarian enzyme activity inhibited by Cd exposure in mice, but it did not reverse the in vitro metal effect. This study detected a new toxicity marker of Cd toxicity on ovarian tissue as well as the beneficial effect of a new compound to manage the metal effect after acute exposure.

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Section: Discussionmentioning

confidence: 99%

Cadmium inhibits the ovary δ‐aminolevulinate dehydratase activity in vitro and ex vivo: protective role of seleno‐furanoside

Vargas

Soares

Izaguirry

et al. 2012

J of Applied Toxicology

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show abstract

“…In laboratory animals, Cd exposure has been associated with a decrease in estradiol (Zhang et al 2008) and in LH and follicle-stimulating hormone (Paksy et al 1989; Pillai et al 2003). Cd also is known to accumulate in the granulosa cells of the ovary (Nampoothiri and Gupta 2006).…”

Section: Discussionmentioning

confidence: 99%

Association between Lead and Cadmium and Reproductive Hormones in Peripubertal U.S. Girls

Gollenberg

Hediger

Lee

et al. 2010

Environ Health Perspect

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BackgroundLead (Pb) and cadmium (Cd) are known reproductive toxicants thought to disrupt hormone production throughout sensitive developmental windows, although this has not been previously examined in nationally representative peripubertal children.ObjectivesWe examined the association between blood Pb and urinary Cd concentrations and the reproductive hormones inhibin B and luteinizing hormone (LH) in girls 6–11 years of age who participated in the cross-sectional Third National Health and Nutrition Examination Survey (NHANES III) (1988–1994).MethodsPb (micrograms per deciliter) was measured in whole blood, and Cd was measured in urine (nanograms per milliliter). Inhibin B (picograms per milliliter) and LH (milli–International units per milliliter) were measured in residual sera for 705 girls. Survey logistic regression was used to estimate associations with pubertal onset based on inhibin B concentration > 35 pg/mL or LH concentration > 0.4 mIU/mL, and multinomial logistic regression was used to estimate the association between Pb and increasing categories of hormone concentrations.ResultsHigh Pb (≥ 5 μg/dL) was inversely associated with inhibin B > 35 pg/mL [odds ratio (OR) = 0.26; 95% confidence interval (CI), 0.11–0.60; compared with Pb < 1 μg/dL]. At 10 and 11 years of age, girls with low Pb (< 1 μg/dL) had significantly higher inhibin B than did girls with moderate (1–4.99 μg/dL) or high Pb (≥ 5 μg/dL). In the subsample of 260 girls with levels of inhibin B above the level of detection and using survey regression modeling, inhibin B levels were lower among girls with both high Pb and high Cd (β = −0.52; 95% CI, −0.09 to −1.04) than among girls with high Pb alone (β = −0.35; 95% CI, −0.13 to −0.57), relative to girls with low Pb and low Cd.ConclusionsHigher Pb was inversely associated with inhibin B, a marker of follicular development, and estimated effects suggestive of pubertal delays appeared to be stronger in the context of higher Cd concentrations. These data underscore the importance of Pb and Cd as reproductive toxicants for young girls.

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“…Rats show dose- and age-dependent toxicity in the ovaries, uterus, and cervix. Cd administration profoundly alters ovarian steroidogenesis (Paksy et al 1989, 1997a, 1997b; Piasek and Laskey 1994; Zhang et al 2008) associated with a reduction in progesterone secretion. Similarly, exposure of cultured human (Paksy et al 1997a) and rat (Zhang and Jia 2007) ovarian granulosa cells to Cd causes a reduction in progesterone production.…”

mentioning

confidence: 99%

Cadmium Increases Human Fetal Germ Cell Apoptosis

Angenard

Muczynski

Coffigny

et al. 2010

Environ Health Perspect

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BackgroundCadmium (Cd) is a common environmental pollutant and a major constituent of tobacco smoke. Adverse effects of this heavy metal on reproductive function have been identified in adults; however, no studies have examined its effects on human reproductive organs during development.ObjectivesUsing our previously developed organ culture system, we investigated the effects of cadmium chloride on human gonads at the beginning of fetal life, a critical stage in the development of reproductive function.MethodsHuman fetal gonads were recovered during the first trimester (7–11 weeks postconception) and cultured with or without Cd. We used different concentrations of Cd and compared results with those obtained with mouse fetal gonads at similar stages.ResultsCd, at concentrations as low as 1 μM, significantly decreased the germ cell density in human fetal ovaries. This correlated with an increase in germ cell apoptosis, but there was no effect on proliferation. Similarly, in the human fetal testis, Cd (1 μM) reduced germ cell number without affecting testosterone secretion. In mouse fetal gonads, Cd increased only female germ cell apoptosis.ConclusionsThis is the first experimental demonstration that Cd, at low concentrations, alters the survival of male and female germ cells in humans. Considering data demonstrating extensive human exposure, we believe that current environmental levels of Cd could be deleterious to early gametogenesis.

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Cadmium exerts toxic effects on ovarian steroid hormone release in rats

Cited by 70 publications

References 9 publications

Cadmium inhibits the ovary δ‐aminolevulinate dehydratase activity in vitro and ex vivo: protective role of seleno‐furanoside

Cadmium inhibits the ovary δ‐aminolevulinate dehydratase activity in vitro and ex vivo: protective role of seleno‐furanoside

Association between Lead and Cadmium and Reproductive Hormones in Peripubertal U.S. Girls

Cadmium Increases Human Fetal Germ Cell Apoptosis

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