Long-term exposure to the non-steroidal anti-inflammatory drug (NSAID) naproxen causes thyroid disruption in zebrafish at environmentally relevant concentrations

Niu, Lili; Guo, Hangqin; Sun, Xiaohui; Chen, Lihui; Tu, Wenqing; Dai, Qizhou; Ye, Jing; Liu, Weiping; Xu, Chao

doi:10.1016/j.scitotenv.2019.04.323

Cited by 60 publications

(15 citation statements)

References 62 publications

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“…It was shown that naproxen can accumulate in the bile of fishes where its concentration was 1000 times higher than this detected in samples of the lake (Brozinski et al 2012). One explanation for the naproxen bioaccumulation may be the suppression of the metabolizing enzyme activity (Xu et al 2019). Moreover, the presence of phase II metabolites in fish bile such as glucuronides was also detected.…”

Section: Occurrence Of Naproxen In the Environmentmentioning

confidence: 92%

“…It has also been postulated that naproxen may cause thyroid disruption in zebrafish because of the relatively high degree of similarity of the thyroid axis between humans and fishes. Xu et al (2019) demonstrated a decrease in the thyroid hormone levels in zebrafish after exposure to naproxen. They postulated that this phenomenon resulted from a disturbance in the gene transcription along the hypothalamic-pituitary-thyroid axis and a significant decrease in transthyretin level (Xu et al 2019).…”

Section: Occurrence Of Naproxen In the Environmentmentioning

confidence: 96%

“…According to ClinCalc (2019), it was prescribed 11,470,076 times in the USA in 2016. The popularity of naproxen in the treatment of pain has resulted in its occurrence in the environment (Aguilar et al 2019;Madikizela et al 2017;Xu et al 2019).…”

Section: Occurrence Of Naproxen In the Environmentmentioning

confidence: 99%

“…Moreover, the presence of phase II metabolites in fish bile such as glucuronides was also detected. These intermediates undergo enzymatic deconjugation (Brozinski et al 2012; Xu et al 2019). It was also shown that naproxen at environmental concentrations may affect the mRNA expression and cause gastrointestinal and renal effects in zebrafish (Ding et al 2017).…”

Section: Occurrence Of Naproxen In the Environmentmentioning

confidence: 99%

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Naproxen in the environment: its occurrence, toxicity to nontarget organisms and biodegradation

Wojcieszyńska

Guzik

2020

Appl Microbiol Biotechnol

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This article summarizes the current knowledge about the presence of naproxen in the environment, its toxicity to nontarget organisms and the microbial degradation of this drug. Currently, naproxen has been detected in all types of water, including drinking water and groundwater. The concentrations that have been observed ranged from ng/L to μg/L. These concentrations, although low, may have a negative effect of long-term exposure on nontarget organisms, especially when naproxen is mixed with other drugs. The biological decomposition of naproxen is performed by fungi, algae and bacteria, but the only well-described pathway for its complete degradation is the degradation of naproxen by Bacillus thuringiensis B1(2015b). The key intermediates that appear during the degradation of naproxen by this strain are O-desmethylnaproxen and salicylate. This latter is then cleaved by 1,2-salicylate dioxygenase or is hydroxylated to gentisate or catechol. These intermediates can be cleaved by the appropriate dioxygenases, and the resulting products are incorporated into the central metabolism. Key points •High consumption of naproxen is reflected in its presence in the environment. •Prolonged exposure of nontargeted organisms to naproxen can cause adverse effects. •Naproxen biodegradation occurs mainly through desmethylnaproxen as a key intermediate.

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Section: Occurrence Of Naproxen In the Environmentmentioning

confidence: 92%

Section: Occurrence Of Naproxen In the Environmentmentioning

confidence: 96%

Section: Occurrence Of Naproxen In the Environmentmentioning

confidence: 99%

Section: Occurrence Of Naproxen In the Environmentmentioning

confidence: 99%

See 2 more Smart Citations

Naproxen in the environment: its occurrence, toxicity to nontarget organisms and biodegradation

Wojcieszyńska

Guzik

2020

Appl Microbiol Biotechnol

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“…NPX present in the environment is regarded as an anthropogenic activity marker, and is related to the presence of other pharmaceuticals, such as diclofenac, ibuprofen, ofloxacin, acetaminophen, progesterone, ranitidine and testosterone, discharged in sewage systems [5]. The noxiousness of NPX is commonly associated with its potential effect as endocrine disruptor, where the drug acts mainly in the thyroid system when the organism has been subjected to a long exposure to the drug, leading to bioaccumulation and decline in the levels of triiodothyronine and thyroxine hormones [6].…”

Section: Introductionmentioning

confidence: 99%

Using Bismuth Vanadate/Copper Oxide Nanocomposite as Photoelectrochemical Sensor for Naproxen Determination in Sewage

et al. 2020

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Conventional sewage treatment plants are not usually designed to remove emerging contaminants, and this shortcoming leads to the discharge of pharmaceuticals, among other emerging pollutants, into the environment. The present work reports the development of BiVO4/CuO‐based photoelectrochemical sensor for the determination of naproxen in sewage samples. Morphological characterizations were carried out by X‐ray diffraction and Scanning electron microscopy. The band gap energy of the nanocomposite material was calculated by Tauc plots using the data obtained from diffuse reflectance spectroscopy analysis. The sensor presented analytical signal during the photocurrent generation simultaneously with the oxidation of naproxen on the working electrode. The sensor responses were found to be proportional to the increase in naproxen concentration in the linear range of 5 nmol L−1 to 480 nmol L−1, R2=0.996, with a limit of detection of 5 nmol L−1. The presence of naproxen in sewage samples was successfully determined with recovery percentages above 95 %.

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Overview of Non-steroidal Anti-inflammatory Drugs as Emerging Contaminants

Mejía-García

Islas-Flores

Gómez-Oliván

et al. 2020

The Handbook of Environmental Chemistry

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Long-term exposure to the non-steroidal anti-inflammatory drug (NSAID) naproxen causes thyroid disruption in zebrafish at environmentally relevant concentrations

Cited by 60 publications

References 62 publications

Naproxen in the environment: its occurrence, toxicity to nontarget organisms and biodegradation

Naproxen in the environment: its occurrence, toxicity to nontarget organisms and biodegradation

Using Bismuth Vanadate/Copper Oxide Nanocomposite as Photoelectrochemical Sensor for Naproxen Determination in Sewage

Overview of Non-steroidal Anti-inflammatory Drugs as Emerging Contaminants

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