Use of honey associated with Ananas comosus (Bromelin) in the treatment of acute irritative cough

Abstract

Objective:To evaluate the immediate improvement rate of irritative cough in patients treated with the combination of Ananas comosus extract and honey (Bromelin®) compared with the use of honey alone (placebo group).Methods:Pragmatic, double-blind, randomized, parallel-group study with children aged between 2 and 15 years, with irritative cough for at least 24hours. The double-blind assessment of cough was through the number of observed coughing episodes and intensity score for a period of 10minutes of observation. The decrease of one point in the mean total score was considered as a therapeutic effect.Results:There was a reduction in coughing episodes in both groups, as well as in the cough score after 30minutes of drug or honey administration. The change in clinical score above two points, which could indicate marked improvement, occurred in five patients in the bromelin group and only in one in the placebo group, but without significant difference. There were no adverse events.Conclusions:The immediate improvement rate of irritative cough was similar in patients treated with combination of Ananas comosus extract and honey (Bromelin®) compared with the use of honey alone (placebo group). It is possible that honey has a therapeutic effect on mucus and cough characteristics (Clinical Trials: NCT01356693).

Efficacy and safety of the syrup “KalobaTUSS®” as a treatment for cough in children: a randomized, double blind, placebo-controlled clinical trial

“…In addition to the known protective effects of mucilage, and anti-inflammatory and antimicrobial properties of honey, the palatability of honey itself might promote salivation, reducing cough caused by low levels of irritation in the larynx and pharynx [ 31 ]. In conclusion, KalobaTUSS ® is well tolerated and exerts positive effects by reducing the severity and shortening the duration of cough in children.…”

Medications and non-pharmacological measures to alleviate the symptoms of respiratory tract infections in the pediatric population

“…Demulcents are thought to act by creating a protective layer that coats the sensory receptors in the pharynx, reducing the possibility of their activation and triggering the cough reflex. In a 2018 Cochrane review, Oduwole et al (21) analyzed six RCTs (involving 899 children aged 12 months to 18 years) which assessed the effects of honey on acute cough due to upper RTIs (22)(23)(24)(25)(26)(27). In the studies covered by this review, different types of honey (e.g.…”

Ethnomedicinal Uses of Some Common Malaysian Medicinal Plants

“…Both the stem and the fruit extracts, for instance, are rich sources of cysteine proteases (bromelain). A. comosus extract is very rich in both proteolytic enzymes (such as bromelain) and nonproteolytic enzymes [28,29] which are considered a phytotherapeutic drug owing to their characteristics anti-edematous, anti-inflammatory, fibrinolytic, and anti-thrombotic activities [30]. The inedible pineapple peel is also a rich in polyphenols [24].…”