Vascular endothelial growth factor G1612A (rs10434) gene polymorphism and neuropsychiatric manifestations in systemic lupus erythematosus patients

Taha, S.; Gamal, Sherif M.; Nabil, Mohamed; Naeem, Nahla; Labib, Dina; Siam, Ibrahim; Gheita, Tamer A.

doi:10.1016/j.rbre.2016.11.007

Cited by 6 publications

(6 citation statements)

References 17 publications

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“…The results of this study showed that female to male ratio was 12:1in SLE, these results agree with others [22] in a large cohorts study conducted in UK with a total of 924 SLE patients were involved found the ratio was 13;1 ,A study done by [23] in Cairo Egypt of 60 SLE patients male was 4(6.66%) and female was 56(93.33%), other found women are estimated to be six to ten times more likely to develop SLE than man [24] , finally a study done in Algeria found female to male ratio: 10: 1 [25] . These differences between female to male in the incidence of disease may be related to the hormonal role of estrogen and other gonadal hormones which have complex effects on the immune system, also the disease activity increases during pregnancy, a role for female hormones has been proposed.…”

Section: Discussionsupporting

confidence: 92%

Oral Ulceration in Systemic Lupus Erythematosus in Iraqi Patients and the Levels of Serum Vascular Endothelial Growth Factor-A

Ali¹,

Zaidan²

2020

ATMPH

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The aim of this study was to estimate the levels of serum vascular endothelial growth factor (VGEF-A) among systemic lupus erythematosus (SLE) patients with and without oral ulceration in Iraqi sample.The study took place in Mirjan teaching hospital in Hilla city, Babylon (Rheumatology unit) during the period from May 2018 till January 2019. All the subjects were from the same ethnic group (Arabic) and were from the same geographical region. The American College of Rheumatology (ACR) 1997 criteria of SLE was used for diagnosis of SLE. A total of 52 SLE patients and 31 control subjects were recruited for this study.The mean age of SLE patients was (30±9.57) years, while for control subjects was (29±9.44) years, and female to male ratio was (12:1), oral ulcerations was found in 24(46.15%) SLE patients, most of patients were with multiple oral ulcers (54.17%) and with non-painful oral ulcer (62.5%). The mean of serum level of VEGF was found significantly higher (p value 0.001) in SLE patients (142.89±24.37 pg/ml) than control (79.61±12.71pg/ml), and significantly higher in non-painful oral ulcerations than with painful ulcerations (p value 0.04). No significant differences in the level of serum VEGF-A found between patients with oral ulceration (P+OU) and patients without oral ulceration (P-OU).Oral ulceration associated with SLE usually painless, multiple, nonspecific, and most common sites were tongue and labial mucosa. Serum VEGF-A in SLE patients was significantly higher than in than control.

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Section: Discussionsupporting

confidence: 92%

Oral Ulceration in Systemic Lupus Erythematosus in Iraqi Patients and the Levels of Serum Vascular Endothelial Growth Factor-A

Ali¹,

Zaidan²

2020

ATMPH

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“…LA was significantly higher in Arabs than in Europeans and Latin Americans. 27 The anti-Ro and anti-La in this work were positive in 36.7% and 29.9%, respectively which was comparable to the study in Europe, 24 USA 26 and (n ¼ 552) [24] (n ¼ 1366) [25] (n ¼ 896) [28] (n ¼ 3273) [30] (n…”

Section: Discussionsupporting

confidence: 87%

“…24 The wide spectrum in the frequency of the various manifestations of SLE throws light on the crucial role of ethnicity in the presentation and severity of the disease. 21 Newly detected susceptibility loci for Egyptian SLE also revealed a distinct genetic background 30 while a dissimilar climate was further suggested to explain the discrepancy. 5 There is wide geographical variation in the reported incidence and prevalence of SLE and there appears to be a trend of increasing prevalence of the disease with time.…”

Section: Discussionmentioning

confidence: 99%

Adult systemic lupus erythematosus in Egypt: The nation-wide spectrum of 3661 patients and world-wide standpoint

Gheita

Noor

Abualfadl

et al. 2021

Lupus

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Objective The aim of this study was to present the epidemiology, clinical manifestations and treatment pattern of systemic lupus erythematosus (SLE) in Egyptian patients over the country and compare the findings to large cohorts worldwide. Objectives were extended to focus on the age at onset and gender driven influence on the disease characteristics. Patients and method This population-based, multicenter, cross-sectional study included 3661 adult SLE patients from Egyptian rheumatology departments across the nation. Demographic, clinical, and therapeutic data were assessed for all patients. Results The study included 3661 patients; 3296 females and 365 males (9.03:1) and the median age was 30 years (17–79 years), disease duration 4 years (0–75 years) while the median age at disease onset was 25 years (4–75 years). The overall estimated prevalence of adult SLE in Egypt was 6.1/100,000 population (1.2/100,000 males and 11.3/100,000 females).There were 316 (8.6%) juvenile-onset (Jo-SLE) and 3345 adult-onset (Ao-SLE). Age at onset was highest in South and lowest in Cairo (p < 0.0001). Conclusion SLE in Egypt had a wide variety of clinical and immunological manifestations, with some similarities with that in other nations and differences within the same country. The clinical characteristics, autoantibodies and comorbidities are comparable between Ao-SLE and Jo-SLE. The frequency of various clinical and immunological manifestations varied between gender. Additional studies are needed to determine the underlying factors contributing to gender and age of onset differences.

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“…Oral ulceration is a common symptom in SLE patients that has a relationship with VEGF [109]. Additionally, VEGF may be contributed to the raised frequency of neuropsychiatric disorders in SLE patients [110]. Female SLE patients in pregnancy often progress more severely with active SLE and various complications to both mother and fetus.…”

Section: Vegf In Slementioning

confidence: 99%

Vascular Endothelial Growth Factor Biology and Its Potential as a Therapeutic Target in Rheumatic Diseases

Kwon

2021

IJMS

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Rheumatic diseases constitute a diversified group of diseases distinguished by arthritis and often involve other organs. The affected individual has low quality of life, productivity even life-threatening in some severe conditions. Moreover, they impose significant economic and social burdens. In recent years, the patient outcome has been improved significantly due to clearer comprehension of the pathology of rheumatic diseases and the effectiveness of “treat to target” therapies. However, the high cost and the adverse effects are the concerns and full remissions are not often observed. One of the main processes that contributes to the pathogenesis of rheumatic diseases is angiogenesis. Vascular endothelial growth factor (VEGF), a central mediator that regulates angiogenesis, has different isoforms and functions in various physiological processes. Increasing evidence suggests an association between the VEGF system and rheumatic diseases. Anti-VEGF and VEGF receptor (VEGFR) therapies have been used to treat several cancers and eye diseases. This review summarizes the current understanding of VEGF biology and its role in the context of rheumatic diseases, the contribution of VEGF bioavailability in the pathogenesis of rheumatic diseases, and the potential implications of therapeutic approaches targeting VEGF for these diseases.

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Vascular endothelial growth factor G1612A (rs10434) gene polymorphism and neuropsychiatric manifestations in systemic lupus erythematosus patients

Abstract: Polymorphism in the gene coding for VEGF may be associated with increased incidence of neuropsychiatric lupus in SLE patients.

Cited by 6 publications

References 17 publications

Oral Ulceration in Systemic Lupus Erythematosus in Iraqi Patients and the Levels of Serum Vascular Endothelial Growth Factor-A

Oral Ulceration in Systemic Lupus Erythematosus in Iraqi Patients and the Levels of Serum Vascular Endothelial Growth Factor-A

Adult systemic lupus erythematosus in Egypt: The nation-wide spectrum of 3661 patients and world-wide standpoint

Vascular Endothelial Growth Factor Biology and Its Potential as a Therapeutic Target in Rheumatic Diseases

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