Possible links between osteoporosis and periodontal disease

Penoni, Daniela Cia; Leão, Anna Thereza Thomé; Fernandes, Tatiana; Torres, Sandra Regina

doi:10.1016/j.rbre.2016.03.004

Cited by 11 publications

(12 citation statements)

References 25 publications

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“…Different investigations indicate an increase in the risk of developing osteoporosis in various inflammatory conditions [ 38–41 ]. However, several diseases are related to osteoporosis [ 14 ] such as immunological dysfunctions, autoimmune and chronic inflammatory diseases [ 42 ], rheumatoid arthritis (RA) [ 43 ], hematological diseases [ 44 ], inflammatory bowel diseases [ 45 , 46 ] and periodontal disease [ 30 , 32 ,]. Although osteoporosis is not exactly qualified as an immunological disorder, recent studies have reported related molecular pathways between bone biology and biology of inflammation [ 14 , 47–49 ].…”

Section: Discussionmentioning

confidence: 99%

Genetic variation in NOD1/CARD4 and NOD2/CARD15 immune sensors and risk of osteoporosis

et al. 2020

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Abstract The present study was aimed to investigate the relationship between NOD1/CARD4 and NOD2/CARD15 gene polymorphisms and osteoporosis in the Turkish population. The first time we thought that the functional polymorphisms in NOD1/CARD4 and NOD2/CARD15 genes might have triggered the development of osteoporosis. The objective of our study was to determine the relationship between NOD1/CARD4 and NOD2/CARD15 SNPs and osteoporosis. The NOD1/CARD4 (rs5743336) and NOD2/CARD15 (rs2066847) SNPs were analyzed by PCR restriction fragment length polymorphism (PCR-RFLP) in 94 healthy controls and 164 subjects with osteoporosis. PCR products were digested with restriction enzymes AvaI for NOD1/CARD4 and ApaI for NOD2/CARD15. We found that NOD1/CARD4 genotype distribution of AA, GA and GG were 15, 44 and 41% for patients and 17, 46 and 37% for controls, respectively. NOD2/CARD15 mutation was found only in three patients (1.8%) as heterozygote. The results did not show any statistical difference between NOD1/CARD4 and NOD2/CARD15 genotype distribution of patients and healthy groups (χ2 = 1.740, P=0.187; χ2 = 1.311, P=0.519). However, the most frequent AG genotype (46%) of NOD1/CARD4 was observed in healthy controls, GG genotype (44%) of NOD1/CARD4 was observed as the most frequent in osteoporotic patients. NOD2/CARD15 WT/WT genotype, the most frequent genotype, was observed in both groups. Statistical analysis revealed that NOD1/CARD4 and NOD2/CARD15 polymorphisms are not associated with osteoporosis. However, a definite judgement is difficult to be made due to restricted number of patients and small size of control group. Further research is sorely warranted in this direction.

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Section: Discussionmentioning

confidence: 99%

Genetic variation in NOD1/CARD4 and NOD2/CARD15 immune sensors and risk of osteoporosis

et al. 2020

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“…This systematic review was registered at PROSPERO under the code CRD42018085004. This study was conducted following the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines (Supplementary Table 1), 10 adapted by Penoni et al 11 and Almeida et al 12…”

Section: Methodsmentioning

confidence: 99%

Does periodontitis represent a risk factor for rheumatoid arthritis? A systematic review and meta-analysis

Ferreira

Silva

Magno

et al. 2019

Therapeutic Advances in Musculoskeletal

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Periodontitis is an inflammatory disease of dental supporting tissues (gingiva, periodontal ligament, and bone) and it has been suggested as a possible etiology for rheumatoid arthritis (RA). In this systematic review, we aim to verify if periodontitis represents a risk factor for RA. Electronic databases were consulted until March 2018 considering eligibility criteria focusing on: (P, participants) adults; (E, exposure) with periodontitis; (C, comparison) without periodontitis; and (O, outcome) development of RA. Quality assessment of studies and risk-of-bias evaluation were also performed. To undertake a quantitative analysis, the number of persons with RA and a total number of participants for the case group (with periodontitis) and control group (without periodontitis) were used to calculate the odds ratio (OR) with a 95% confidence interval (CI). A total of 3888 articles were identified, and nine studies were considered eligible. Seven of 9 articles suggested an association among diseases by the common pro-inflammatory profiles. The pooled analysis of 3 articles showed a higher RA prevalence for persons with periodontitis ( n = 1177) than controls ( n = 254) (OR 1.97; CI 1.68–2.31; p < 0.00001). However, considerable heterogeneity among studies was verified (I2 = 96%, p < 0.00001). Periodontitis may represent a risk factor for RA by heredity, bacterial infection, and the pro-inflammatory profile shared between both diseases. Although most of the elective studies report an association between periodontitis and RA, the quantitative analysis showed a high heterogeneity, leading to the need for further studies.

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“…[2][3][4][5] The pathogenesis of periodontal disease is a complex process involving individual immune response to subgingival biofilm, associated with increased kappa nuclear factor receptor ligand B (RANKL) and decreased levels of osteoprotegerin in gingival tissue and biological fluids, including saliva and crevicular gingival fluid, resulting in an increased RANKL/OPG ratio. 6 The involvement of the RANKL and OPG system is also well established in postmenopausal osteoporosis, and studies showed an increase in serum levels of RANKL in postmenopausal women with periodontal disease. 7 The deficiency of oestrogenic hormones that occurs in the menopause promotes a reduction in bone mineral density, and may also contribute to the imbalance of the RANK-RANKL-OPG system in periodontal structures, stimulating the increase in serum inflammatory mediators (IL-1, IL-6 and TNF), thus promoting reduction or even loss of alveolar bone insertion.…”

Section: Introductionmentioning

confidence: 99%

Green tea extract rich in epigallocatechin gallate impairs alveolar bone loss in ovariectomized rats with experimental periodontal disease

Sánchez

Pitol

Sousa

et al. 2020

Int J Experimental Path

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Periodontal disease and osteoporosis are characterized by bone resorption, and researchers have shown an association between these two diseases through increasing loss of systemic bone mass and triggering alveolar bone loss. Green tea is a common and easily accessible beverage, and evidences show that flavonoid epigallocatechin gallate (EGCG) could decrease bone loss in pathologies such as osteoporosis and periodontal disease. In order to verify its possible effects and apply them in the treatment and prevention of these diseases, this investigation aimed to evaluate the influence of green tea extract (GTE) on bone metabolism of ovariectomized rats after experimental periodontal disease (EPD) by histological, morphological and microtomographic parameters. Wistar female rats were divided into Sham, Sham + EPD, Sham + EPD + GTE, OVX, OVX + EPD and OVX + EPD + GTE groups. Immediately after surgery, gavage administration of 50 mg/kg of green tea extract (GTE) was performed for 60 days, with subsequent induction of periodontal disease by ligature 15 days before euthanasia. Mandible and femur samples were collected for histological, morphometric and microtomographic analysis. The results were analysed by means of statistical software with significance set at 5%. Histological and morphometric analysis showed a significant decrease in alveolar and femoral trabecular bone loss in groups that received GTE. Microtomographic results showed that trabecular thickness and bone surface density values in alveolar bone interradicular septum of the OVX + EPD + GTE groups were similar to the Sham group. The results obtained suggest that green tea extract may improve bone metabolism in osteoporotic rats with periodontal disease.

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Possible links between osteoporosis and periodontal disease

Cited by 11 publications

References 25 publications

Genetic variation in NOD1/CARD4 and NOD2/CARD15 immune sensors and risk of osteoporosis

Genetic variation in NOD1/CARD4 and NOD2/CARD15 immune sensors and risk of osteoporosis

Does periodontitis represent a risk factor for rheumatoid arthritis? A systematic review and meta-analysis

Green tea extract rich in epigallocatechin gallate impairs alveolar bone loss in ovariectomized rats with experimental periodontal disease

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