Brazilian multicenter study of 71 patients with juvenile-onset Takayasu's arteritis: clinical and angiographic features

Clemente, Gleice; Hilário, Maria Odete Esteves; Len, Cláudio Arnaldo; Silva, Clóvis A.; Sallum, Adriana Maluf Elias; Campos, Lúcia Maria Arruda; Sacchetti, Silvana; Santos, Maria Carolina dos; Alves, Andressa Guariento Ferreira; Ferriani, Virgínia Paes Leme; Sztajnbok, Flávio; Gasparello, Rozana; Oliveira, Sheila Knupp Feitosa de; Lessa, Marise; Cavalcanti, André; Robazzi, Teresa Cristina Martins Vicente; Bandeira, Márcia; Terreri, Maria Teresa

doi:10.1016/j.rbre.2016.01.004

Cited by 21 publications

(22 citation statements)

References 17 publications

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“…Characteristic features of the late, occlusive phase are limb ischemia or absent pulses, vascular bruits, hypertension as a consequence of renal artery stenosis or aortic narrowing and aortic fibrosis, mesenteric angina, retinopathy, aortic regurgitation and neurologic symptoms secondary to hypertension or ischemia. An aortic valve insufficiency and congestive heart failure has been reported in a significant proportion of patients [6,[21][22][23][24][25][26][27][28] The current EULAR/PRINTO/PRES validated classification criteria for childhood Takayasu arteritis are characterized by high sensitivity and specificity assessed as 100% and 99.9%, respectively [7]. The mandatory criterion is the typical angiographic abnormality of the aorta or its main branches and pulmonary arteries found in angiography (conventional, CTA or MRA): aneurysm/dilatation, narrowing, occlusion or thickened arterial wall not due to fibromuscular dysplasia, or similar causes, usually focal or segmental.…”

Section: Discussionmentioning

confidence: 99%

The importance of FDG PET/CT in the diagnostic process of the middle aortic syndrome in a 15-year-old boy patient with suspected systemic vasculitis and final diagnosis of Williams–Beuren syndrome

et al. 2020

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The differential diagnosis in children with the systemic vasculopathy is still a challenge for clinicians. The progress in vascular imaging and the latest recommendations improve the diagnostic process, but only single reports describe the use of new imaging tests in children. The publication aims to demonstrate the important role of 18F-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography combined with anatomical computed tomography angiography (PET/CTA) imaging in the case of a 15-year-old boy with chest pain, intermittent claudication, hypertension and features of middle aortic syndrome in computed tomography angiography (CTA). The patient was suspected to have Takayasu arteritis, but was finally diagnosed with Williams-Beuren syndrome. The case indicates that the FDG PET/CT imaging might be essential in the diagnostic process of middle aortic syndrome in children. We suggest that this imaging technique should be considered in the diagnostic process of systemic vasculopathy particularly in children.

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Section: Discussionmentioning

confidence: 99%

The importance of FDG PET/CT in the diagnostic process of the middle aortic syndrome in a 15-year-old boy patient with suspected systemic vasculitis and final diagnosis of Williams–Beuren syndrome

et al. 2020

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“…To better understand the role of Mycobacterium tuberculosis in patients diagnosed with Takayasu's arteritis, we studied 13 previously published articles, which in total included 196 patients diagnosed with Takayasu's arteritis [11,16,17,[19][20][21][22][23][24][25][26][27][28]. Out of which 68 had either a prior or current tuberculous infection [11,16,17,[19][20][21][22][23][24][25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

“…Over many years, many studies show shreds of evidence implicating the contribution of Mycobacterium tuberculosis in the pathogenesis of TAK [ 21 ]. Our studies found 65 cases of latent tuberculosis in patients diagnosed with TAK [ 11 , 16 , 17 , 19 - 23 , 26 , 28 ]. We discovered that the majority of these observational studies detected latent tuberculosis in a patient diagnosed with TAK.…”

Section: Reviewmentioning

confidence: 96%

“…We discovered that the majority of these observational studies detected latent tuberculosis in a patient diagnosed with TAK. These studies used various methodologies such as the Mantoux tuberculin skin test, Interferon-g release assay (IGRA), and QuantiFERON-TB tests to detect latent tuberculosis in the study subjects [11,16,17,[19][20][21][22][23]26,28].…”

Section: Latent Tuberculosis In Tak Patientsmentioning

confidence: 99%

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Takayasu's Arteritis and Its Association With Mycobacterium Tuberculosis: A Systematic Review

Magar

Kafle

Poudel

et al. 2021

Cureus

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Takayasu's arteritis (TAK) is a rare large vessel vasculitis of unknown etiology that chiefly targets the aorta and its branches. It predominantly affects females under 50 years of age. A relationship between TAK and Mycobacterium tuberculosis (TB) has been suggested for a long time, but only a few systematic studies have been done centering on this association. The present systematic review aimed to analyze the possible association between TAK and TB based on the studies conducted previously. A detailed search was conducted until April 2021 using three databases: PubMed, Cochrane Library, and MedlinePlus. PubMed search on the related topic identified 1053 articles, four on Cochrane Library, and three on MedlinePlus. Finally, 13 papers were pertinent for our review. The appropriate data was extracted from these articles, and the risk of bias assessment was done. The systematic review of these finalized articles found that the majority of the current studies supported the presence of TB in patients with TAK. Out of 13 final observational studies, only one study failed to detect a link between TAK and TB. However, data are still lacking that show a direct link between them. Future large-scale studies are needed to probe the exact role of Mycobacterium tuberculosis infection in the etiopathogenesis of TAK.

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“…Out of the 71 patients selected in the study, 51 of them were girls, showing a higher prevalence in female population. The most frequent finding in laboratory testing was an ESR elevation (9).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic dilemmas in a case of early-onset large vessel vasculitis

Ciotoracu¹,

Ramba²,

Pana³

et al. 2019

Ro J Rheumatol.

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Vasculitides are inflammatory disorders which affect the blood vessels. There are three major categories of vasculitides depending on the size of the injured vessels. Although each category can affect any size artery, usually large vessel vasculitis affects large arteries. Takayasu arteritis and Giant Cell arteritis are known to be the two main types of large vessel arteritis. We present the case of a patient with a delayed diagnosis of Takayasu disease who sequentially develops a series of complications. The atypical evolution of the disease confirms once again the complexity of the vasculitic disorders and raises questions about the understanding of their pathophysiologic mechanisms.

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Brazilian multicenter study of 71 patients with juvenile-onset Takayasu's arteritis: clinical and angiographic features

Abstract: This is the largest study on juvenile-onset Takayasu arteritis, and a high number of patients under the age of 10 years, with predominance of constitutional symptoms early in the disease, was observed.

Cited by 21 publications

References 17 publications

The importance of FDG PET/CT in the diagnostic process of the middle aortic syndrome in a 15-year-old boy patient with suspected systemic vasculitis and final diagnosis of Williams–Beuren syndrome

The importance of FDG PET/CT in the diagnostic process of the middle aortic syndrome in a 15-year-old boy patient with suspected systemic vasculitis and final diagnosis of Williams–Beuren syndrome

Takayasu's Arteritis and Its Association With Mycobacterium Tuberculosis: A Systematic Review

Diagnostic dilemmas in a case of early-onset large vessel vasculitis

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