Intracardiac thrombosis in Behçet's disease: a life threatening event

Madureira, P.; Rodrigues, Mariana; Serrano, Edite; Vítor, Artur Bonito; Brito, Iva

doi:10.1016/j.rbre.2014.11.002

Cited by 2 publications

(4 citation statements)

References 8 publications

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“…Ischemia or endothelial cell rupture, the presence of antiphospholipid antibodies, prothrombotic plasma factors, and deposition of immune complexes in the blood vessel [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Intracardiac Thrombosis: An Uncommon Manifestation of Behçet’s Disease

Ezzahraoui,

Belharty,

Bourouhou

et al. 2023

Cureus

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Behçet’s disease is a chronic multisystemic vasculitis of unknown etiology that evolves in relapses and remissions with a predominance of cutaneous and ocular lesions. It is more frequent in young adults, with a predominantly male population from the Mediterranean and Middle East. Cardiac involvement is rare (1 to 6%) but represents one of the most serious complications that can affect the three tunics of the heart. Cardiac thrombus is uncommon, its diagnosis relies mainly on echocardiography, and the development of the empirical treatment is based on immunosuppressive therapy and anticoagulation depending on the case. We report the case of a 21-year-old man admitted for a 2-month history of fever, loss of weight, and body condition in association with an intracardiac thrombus in the context of Behçet's disease. Intracardiac thrombus is a rare manifestation of Behçet's disease; the diagnosis must be made quickly in order to allow early management.

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“…Ischemia or endothelial cell rupture, the presence of antiphospholipid antibodies, prothrombotic plasma factors, and deposition of immune complexes in the blood vessel [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Intracardiac Thrombosis: An Uncommon Manifestation of Behçet’s Disease

Ezzahraoui,

Belharty,

Bourouhou

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…In addition, another case of BD developed two intracardiac thrombi while on oral prednisolone and colchicine [ 9 ]. He was immediately started on low-molecular-weight heparin followed by oral warfarin in addition to immunosuppressant (prednisolone and monthly cyclophosphamide) [ 9 ]. Interestingly, four months later, cardiac MRI revealed complete resolution of the intracardiac, pulmonary, and superior vena cava thrombosis [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…He was immediately started on low-molecular-weight heparin followed by oral warfarin in addition to immunosuppressant (prednisolone and monthly cyclophosphamide) [ 9 ]. Interestingly, four months later, cardiac MRI revealed complete resolution of the intracardiac, pulmonary, and superior vena cava thrombosis [ 9 ]. The latest case report can conclude that prednisolone and colchicine may not be adequate in preventing vascular complications of BD.…”

Section: Discussionmentioning

confidence: 99%

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Intracardiac Thrombus Formation and Bilateral Pulmonary Embolisms in a Patient With Behcet's Disease While on Regular Infliximab Infusion: A Case Report

Miqdad¹,

Mohamad²,

Ali³

et al. 2021

Cureus

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Vascular complications of Behcet's disease, including intracardiac thrombus formation, are one of the significant causes of mortality and morbidity in this population. Similar to other vasculitic disorders, Behcet's disease is primarily treated with immunosuppressants. While the benefit of adding anticoagulants in Behcet's disease with thromboembolism remains debatable, some literature encourages its use with concomitant intracardiac thrombus. Herewith, we present the case of a young male who was diagnosed with bilateral pulmonary embolism in addition to right ventricle intracardiac thrombus upon his scheduled dose of infliximab infusion. He was managed by adding azathioprine to his regimen together with oral prednisolone and warfarin with a target international normalized ratio of 2-3. This case report addresses the importance and outcome of early identification of Behcet's disease's vascular complications and immediate initiation of anticoagulation accordingly.

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Intracardiac thrombosis in Behçet's disease: a life threatening event

Abstract: No. of Pages 3 r e v b r a s r e u m a t o l . 2 0 1 5;x x x(x x):xxx-xxx REVISTA BRASILEIRA DE REUMATOLOGIA w w w . r e u m a t o l o g i a . c o m . b r

Cited by 2 publications

References 8 publications

Intracardiac Thrombosis: An Uncommon Manifestation of Behçet’s Disease

Intracardiac Thrombosis: An Uncommon Manifestation of Behçet’s Disease

Intracardiac Thrombus Formation and Bilateral Pulmonary Embolisms in a Patient With Behcet's Disease While on Regular Infliximab Infusion: A Case Report

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