N‐acetilcisteína oral no tratamento do fenômeno de Raynaud secundário à esclerose sistêmica: ensaio clínico randomizado, placebo‐controlado e duplo‐cego

Corrêa, Marcelo José Uchôa; Mariz, Henrique de Ataíde; Andrade, Luís Eduardo Coelho; Kayser, Cristiane

doi:10.1016/j.rbr.2014.07.001

Cited by 14 publications

(2 citation statements)

References 35 publications

(37 reference statements)

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“…N-acetylcysteine (NAC), a scavenger of free radicals and a precursor of the major antioxidant glutathione, was shown to be beneficial for SSc patients when administered intravenously in several studies [95], [96], [97], but given orally, it failed to have favourable effects [98]. NAC inhibits fibroblast proliferation and collagen synthesis [7], [99] and reduces peroxynitrite production by activated lung macrophages from SSc patients in vitro [100].…”

Section: Targeting Oxidative Stress To Treat Sscmentioning

confidence: 99%

Implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation, autoimmunity and fibrosis

et al. 2019

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Systemic sclerosis is an autoimmune disorder characterized by inflammation and a progressive fibrosis affecting the skin and visceral organs. Over the last two decades, it became clear that oxidative stress plays a key role in its pathogenesis. In this review, we highlighted the role of ROS in the various pathological components of systemic sclerosis, namely the inflammatory, the autoimmune and the fibrotic processes. We also discussed how these pathological processes can induce ROS overproduction, thus maintaining a vicious circle. Finally, we summarized the therapeutic approaches targeting oxidative stress tested in systemic sclerosis, in cells, animal models and patients.

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Section: Targeting Oxidative Stress To Treat Sscmentioning

confidence: 99%

Implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation, autoimmunity and fibrosis

et al. 2019

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“…Indiretamente a NAC age mediante a indução da síntese de glutationa, cuja a função é a remoção de radicais livres e defesa contra estresse oxidativo. Devido a essas características, a NAC é utilizada não só como agente mucolítico em uma variedade de doenças respiratórias, mas também em condições caracterizadas pelo estresse oxidativo ou pela diminuição da glutationa (Correa et al, 2014).…”

Section: Introductionunclassified

Intoxicação por metaldeído em cão: Relato de caso

Pasquali¹,

Itame²,

Rosa³

et al. 2021

Pubvet

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Em função do uso do veneno de caracóis (metaldeído) e pela facilidade da ingestão do mesmo pelos animais domésticos, a intoxicação de cães se torna comum. Dentre as várias alterações, as que se destacam são hipersalivação, convulsões, danos renais e hepáticos. O tratamento consiste no controle dos sinais clínicos e redução dos danos sistêmicos causados principalmente pelo estresse oxidativo. A N-acetilcisteína, neste caso, atuou como antioxidante, tendo um papel fundamental para a recuperação do paciente.

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Thermoregulation of the hand: assessment with infrared thermography

Ospina-Restrepo

Herrera-Velasquez

Barrera-Causil

et al. 2017

VII Latin American Congress on Biomedical Engineering CLAIB 2016, Bucaramanga, Santander, Colombia, October 26th -28th, 2016

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N‐acetilcisteína oral no tratamento do fenômeno de Raynaud secundário à esclerose sistêmica: ensaio clínico randomizado, placebo‐controlado e duplo‐cego

Abstract: NAC orally at a dose of 1800mg/day showed no vasodilator effect on hands' microcirculation after four weeks of treatment in patients with RP secondary to SSc.

Cited by 14 publications

References 35 publications

Implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation, autoimmunity and fibrosis

Implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation, autoimmunity and fibrosis

Intoxicação por metaldeído em cão: Relato de caso

Thermoregulation of the hand: assessment with infrared thermography

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