Tireoidite de Hashimoto pode estar associada a um subgrupo de pacientes de esclerose sistêmica com hipertensão pulmonar

Costa, Ciliana Cardoso B.; Medeiros, Morgana; Watanabe, Karen H.; Martin, Patrícia; Skare, Thelma Larocca

doi:10.1016/j.rbr.2014.04.001

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…Thyroid hormone deficiency, when severe and untreated, may be a life-threatening condition especially in patients with comorbidities such as SSc. Although all of the organs and main systems can be interested in this disease, PAH is the major cause of mortality in patients with SSc ( 8 ). The onset of autoimmune hypothyroidism can worsen the prognosis of PAH in SSc ( 9 , 10 ).…”

Section: Discussionmentioning

confidence: 99%

Severe Hypothyroidism due to the Loss of Therapeutic Efficacy of l-Thyroxine in a Patient with Esophageal Complication Associated with Systemic Sclerosis

et al. 2017

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BackgroundThyroid function abnormalities and thyroid autoantibodies have been frequently described in patients with systemic autoimmune diseases as systemic sclerosis (SSc). Serum TSH levels are higher in SSc patients with more severe skin diseases and a worse modified Rodnan skin score. Asymptomatic esophageal involvement due to SSc has never been described as a cause of severe hypothyroidism due to l-thyroxine (l-T4) malabsorption in patients with Hashimoto’s thyroiditis (HT) and SSc.Case reportHere, we report a case of a 56-year-old female affected by both SSc and HT who developed severe hypothyroidism due to the loss of therapeutic efficacy of l-T4. Therapeutic failure resulted from the altered l-T4 absorption because of SSc esophageal complications. Clinical findings improved after the administration of oral liquid l-T4. Thyroid function completely normalized with a full clinical recovery, the disappearance of the pericardial effusion and the improvement of the pulmonary pressure.ConclusionA recognition of a poor absorption is crucial in patients with hypothyroidism and SSc to reduce the risk of the subsequent adverse events. This case suggests the importance of clinical and laboratory surveillance in patients with SSc and HT because the systemic complications of these dysfunctions may worsen the prognosis of hypothyroid SSc/HT patients.

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Section: Discussionmentioning

confidence: 99%

Severe Hypothyroidism due to the Loss of Therapeutic Efficacy of l-Thyroxine in a Patient with Esophageal Complication Associated with Systemic Sclerosis

et al. 2017

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“…In some cases the diseases were also associated with the presence of systemic sclerosis. Another study shows a prevalence of 20% of Hashimoto thyroiditis in 56 patients with systemic sclerosis (Costa et al, 2014).…”

Section: Introductionmentioning

confidence: 97%

Study of the environmental and individual factors of autoimmune diseases in the microregion of Águas Formosas – Minas Gerais State, Brazil

Junior

Castro

Amorim

et al. 2021

RSD

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Autoimmune diseases lead to numerous limiting conditions. Their incidence and prevalence are known to be affected by several factors; and there is an absence of data in areas of economic vulnerability. The aim of this study was to access the epidemiological profile of autoimmune diseases in the public health system of the microregion of health of Águas Formosas, and to evaluate possible factors involved in the development of these diseases. This was an epidemiological study with a cross-sectional, survey-type, descriptive and exploratory. All patients were selected according to the inclusion criteria, and individual interview was conducted during home visits to apply a sociodemographic questionnaire with 20 variables associated with autoimmune diseases. In this study, it was observed that the municipalities of Machacalis, Umburatiba and Crisólita exhibited prevalence of autoimmune diseases above 90 cases per 10,000 of the population, and the other municipalities showed prevalence between 50 and 60 cases. In the microregion, a total of 407 cases of autoimmune diseases were observed, distributed in 24 different diseases, with a general prevalence of 673.69/100,000 of the population. Hashimoto's Thyroiditis, Graves' Disease, Vitiligo, Rheumatoid Arthritis, Psoriasis, Type 1 Diabetes Mellitus and Systemic Lupus Erythematosus, represent 47% of the cases. This was the first study that addresses the prevalence of autoimmune diseases in the microregion. The lack of registration or diagnosis is a factor that needs to be overcome in new studies to improve the knowledge of autoimmune diseases in this region.

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Pulmonary hypertension in thyroid diseases

Scicchitano¹,

Dentamaro

Tunzi³

et al. 2016

Endocrine

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The influence of thyroid hormones on cardiovascular system is well established. Thyroid diseases can effectively enhance the alteration on cardiovascular system by influencing chronotropic and inotropic actions of the heart; altering the strength and the speed of contraction, the speed of relaxation, the duration of the potential of action, and the duration of the refractory period and atrio-ventricular conduction time; modulating circulation and peripheral vascular beds. One of the more intriguing insights in the connection between thyroid diseases and cardiovascular alterations is related to the evaluation of the influence of thyroid hormones on pulmonary vascular beds. Literature reported several studies regarding the association between both hypothyroidism and hyperthyroidism and the occurrence of increased vascular pulmonary arterial pressure. Nevertheless, the pathogenetic mechanisms able to explain such relationship are not fully understood. Many doubts still persist in the comprehension of the mechanisms of pulmonary hypertension in thyroid diseases. The aim of this review was to provide possible explanation about the possible interaction between pulmonary vascular beds and thyroid function in order to evaluate the possibility of novel perspectives in the general management of patients suffering from thyroid and cardiovascular diseases.

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Tireoidite de Hashimoto pode estar associada a um subgrupo de pacientes de esclerose sistêmica com hipertensão pulmonar

Abstract: In the studied sample patients with ES and HT had higher prevalence of pulmonary hypertension. Long-term follow-up studies with a larger number of TH and SSc patients are needed to confirm these data.

Cited by 6 publications

References 23 publications

Severe Hypothyroidism due to the Loss of Therapeutic Efficacy of l-Thyroxine in a Patient with Esophageal Complication Associated with Systemic Sclerosis

Severe Hypothyroidism due to the Loss of Therapeutic Efficacy of l-Thyroxine in a Patient with Esophageal Complication Associated with Systemic Sclerosis

Study of the environmental and individual factors of autoimmune diseases in the microregion of Águas Formosas – Minas Gerais State, Brazil

Pulmonary hypertension in thyroid diseases

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