Exposição à periodontite no intervalo de um ano antes do tratamento antidiabético e risco de artrite reumatoide em pacientes com diabete mellitus: estudo de coorte populacional

Chen, Hsin‐Hua; Chen, Der‐Yuan; Lin, Shih‐Yi; Lai, Kuo-Lung; Chen, Yiming; Chou, Yiing Jenq; Chou, Pesus; Lin, Ching‐Heng; Huang, Nicole

doi:10.1016/j.rbr.2014.03.007

Cited by 8 publications

(3 citation statements)

References 38 publications

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“…A dose–response relationship between PD and RA risk was also observed when PD-related utilizations were used as the proxy measures of PD severity. Consistent with the findings of two recent case-control studies [ 19 , 21 ] and one population-based diabetic cohort study [ 20 ], the results of this cohort study suggested that PD exposure is associated with a greater risk of RA development. In our previous case-controlled study, the risk of RA associated with PD exposure (odds ratio, 1.16; 95% CI, 1.12–1.20) was lower than that estimated in this study.…”

Section: Discussionsupporting

confidence: 91%

Rheumatoid Arthritis Risk Associated with Periodontitis Exposure: A Nationwide, Population-Based Cohort Study

et al. 2015

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BackgroundThe risk of periodontitis (PD) is increased in the patient group of rheumatoid arthritis (RA). RA and PD also shared some pathological mechanism. The aim of this study is to investigate the risk of RA associated with PD exposure.Methods and FindingsThis study identified 3 mutually exclusive cohorts using the 1999–2010 Taiwanese National Health Insurance Research Database (NHIRD) to investigate the association between PD and the risk of incident RA. All patients with PD in 2000 were identified from the database of all enrollees as the PD cohort. From the representative database of 1,000,000 enrollees randomly selected in 2010 (LHID2010), individuals without any periodontal disease (PO) during 1999–2010 were selected as the non-PO cohort. Individuals who were not included in the non-PO cohort and received dental scaling (DS) no more than two times per year during 1999–2010 were selected as the DS cohort from LHID2010. Using cox proportional regression analysis, hazard ratios (HRs) with 95% confidence intervals (Cis) were calculated to quantify the association between PD exposure and RA development. In the three-group comparison using the non-PO cohort as reference, we found that the risk of RA was higher in the PD and DS cohorts (HRs, 1.89 and 1.43; 95% CIs, 1.56–2.29 and 1.09–1.87, respectively). For comparisons between two cohorts, the PD cohort had a higher risk of RA than the non-PO and DS cohorts (HRs, 1.91 and 1.35; 95% CIs, 1.57–2.30 and 1.09–1.67, respectively).ConclusionPD was associated with an increased risk of RA development.

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Section: Discussionsupporting

confidence: 91%

Rheumatoid Arthritis Risk Associated with Periodontitis Exposure: A Nationwide, Population-Based Cohort Study

et al. 2015

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“…Other potential confounders included CCI as adapted by Deyo et al 54 , periodontitis as defined in our previous study 18 , and the use of statin drugs for ≥28 days within the year prior to the index date. Periodontitis was selected because it has been found to increase the risk of RA 17 18 . Statins were chosen as a potential confounder because their persistent use has been reported to reduce the RA risk 55 .…”

Section: Methodsmentioning

confidence: 99%

“…Recently, the Taiwanese National Health Insurance Research Database (NHIRD) made population-based longitudinal studies feasible. We have successfully utilized the NHIRD to conduct several epidemiologic studies of RA 16 17 18 . The first part of the present study aimed to conduct a population-based, matched case-control study to examine the potential RA-protective effect of acarbose using the NHIRD.…”

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confidence: 99%

Acarbose Decreases the Rheumatoid Arthritis Risk of Diabetic Patients and Attenuates the Incidence and Severity of Collagen-induced Arthritis in Mice

Chen

Chao

et al. 2015

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Acarbose has been found to decrease some inflammatory parameters in diabetic patients. This study aimed to examine the influence of acarbose on rheumatoid arthritis (RA) risk in diabetes mellitus (DM) patients and on the incidence and severity of collagen-induced arthritis (CIA) in mice. In a nationwide, matched case–control study, we identified 723 incident RA cases and selected 7,230 age-, sex- and RA diagnosis date–matched controls from all newly treated DM patients. We found that use of acarbose at > 16,950 mg per year was associated with a lower RA risk (odds ratio 0.60; 95% CI, 0.41–0.89). In the CIA mouse study, acarbose was orally administered from days -7 to 38 relative to type II collagen (CII) immunization. The results revealed that acarbose at the dose of 500 mg/kg/day attenuated the incidence and severity of arthritis and the expression of proinflammatory cytokines, including TNF-α, IL-6 and IL-17 in the paw tissues. Acarbose further decreased the productions of anti-CII-IgG, IL-17 and IFN-γ by collagen-reactive lymph node cells. This work suggests that the use of acarbose decreased RA risk in DM patients and the incidence of CIA in mice. Acarbose also attenuated the severity of CIA via anti-inflammatory and immunomodulatory effects.

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Periodontitis and periodontopathic bacteria as risk factors for rheumatoid arthritis: A review of the last 10 years

Kobayashi,

Bartold

2023

Japanese Dental Science Review

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Exposição à periodontite no intervalo de um ano antes do tratamento antidiabético e risco de artrite reumatoide em pacientes com diabete mellitus: estudo de coorte populacional

Abstract: PD exposure within one year before anti-diabetic treatment was associated with increased RA risk in newly treated DM patients. The lack of knowledge about individual smoking status is a major limitation of this study.

Cited by 8 publications

References 38 publications

Rheumatoid Arthritis Risk Associated with Periodontitis Exposure: A Nationwide, Population-Based Cohort Study

Rheumatoid Arthritis Risk Associated with Periodontitis Exposure: A Nationwide, Population-Based Cohort Study

Acarbose Decreases the Rheumatoid Arthritis Risk of Diabetic Patients and Attenuates the Incidence and Severity of Collagen-induced Arthritis in Mice

Periodontitis and periodontopathic bacteria as risk factors for rheumatoid arthritis: A review of the last 10 years

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