Schizophrenia: Progress in multidisciplinary treatment

Nunes, Emerson Arcoverde

doi:10.1016/j.rbp.2012.10.003

Cited by 1 publication

(1 citation statement)

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“…This paradigm consists on a reduction of the startle reaction to a stimulus when it is immediately preceded by a low-intensity stimulus called prepulse. The PPI deficit is one of the most used paradigms in animal models of schizophrenia, since there is a similarity of the phenomenon in different species, which favors its use in translational approaches [122]. Before the start of the test, a calibration of the platforms was performed to ensure an equivalence in sensitivity throughout the experiment in all 4 boxes for acoustic startle response evaluation.…”

Section: Methodsmentioning

confidence: 99%

Thimet Oligopeptidase (EC 3.4.24.15) Key Functions Suggested by Knockout Mice Phenotype Characterization

et al. 2019

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Thimet oligopeptidase (THOP1) is thought to be involved in neuropeptide metabolism, antigen presentation, neurodegeneration, and cancer. Herein, the generation of THOP1 C57BL/6 knockout mice (THOP1−/−) is described showing that they are viable, have estrus cycle, fertility, and a number of puppies per litter similar to C57BL/6 wild type mice (WT). In specific brain regions, THOP1-/- exhibit altered mRNA expression of proteasome beta5, serotonin 5HT2a receptor and dopamine D2 receptor, but not of neurolysin (NLN). Peptidomic analysis identifies differences in intracellular peptide ratios between THOP1-/- and WT mice, which may affect normal cellular functioning. In an experimental model of multiple sclerosis THOP1-/- mice present worse clinical behavior scores compared to WT mice, corroborating its possible involvement in neurodegenerative diseases. THOP1-/- mice also exhibit better survival and improved behavior in a sepsis model, but also a greater peripheral pain sensitivity measured in the hot plate test after bradykinin administration in the paw. THOP1-/- mice show depressive-like behavior, as well as attention and memory retention deficits. Altogether, these results reveal a role of THOP1 on specific behaviors, immune-stimulated neurodegeneration, and infection-induced inflammation.

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Section: Methodsmentioning

confidence: 99%