A Case-control Association Study Between Obsessive-Compulsive Disorder (OCD) and the MCP-1 -2518G/A Polymorphism in a Chinese Sample

Obsessive–compulsive disorder (OCD) affects about 2% of the general population, for which several etiological factors were identified. Important among these is immunological dysfunction. This review aims to show how immunology can inform specific etiological factors, and how distinguishing between these etiologies is important from a personalized treatment perspective. We found discrepancies concerning cytokines, raising the hypothesis of specific immunological etiological factors. Antibody studies support the existence of a potential autoimmune etiological factor. Infections may also provoke OCD symptoms, and therefore, could be considered as specific etiological factors with specific immunological impairments. Finally, we underline the importance of distinguishing between different etiological factors since some specific treatments already exist in the context of immunological factors for the improvement of classic treatments.

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A Case-control Association Study Between Obsessive-Compulsive Disorder (OCD) and the MCP-1 -2518G/A Polymorphism in a Chinese Sample

Abstract: Our results indicated that MCP-1 -2518G/A may not play a major role in the genetic predisposition of the Chinese Han population to OCD. However, further studies using a larger number of subjects are required to obtain a clear conclusion.

Cited by 3 publications

References 10 publications

Immune Dysfunction in Obsessive-Compulsive Disorder: From Risk Factors to Multisystem Involvement

Immune Dysfunction in Obsessive-Compulsive Disorder: From Risk Factors to Multisystem Involvement

MCP-1-2518A>G Polymorphism and Myocardial Infarction Risk: A Meta-Analysis and Meta-Regression

Individualized Immunological Data for Precise Classification of OCD Patients

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