Effects of simvastatin associated with exercise on the mechanical resistance of muscle and bone in rats

Abstract

ObjectiveThe aim of the present study was to evaluate the influence of simvastatin on mechanical properties of muscle and bone in hypercholesterolemic rats submitted to physical exercise.MethodsTen male Wistar rats were submitted to a high-fat diet rich in cholesterol for 90 days. The animals were then divided into two groups: animals treated with physical exercise (EG) and animals treated with physical exercise and simvastatin (ESG). Protocols for physical exercise in water and simvastatin administration were performed for eight weeks. After this period, the animals were euthanized; the left tibia and right gastrocnemius muscle were dissected for mechanical analysis, and the right tibia for densitometry. The data were analyzed using Student's t-test, considering a level of significance of 5%.ResultsThe comparison of maximum load and stiffness revealed no significant differences between the groups for both the tibia (p = 0.851 and p = 0.259) and the gastrocnemius (p = 0.911 and p = 0.083). The tibia BMD also showed no significant difference between the groups (p = 0.803).ConclusionSimvastatin had no negative effects on mechanical properties in tibia and gastrocnemius of hypercholesterolemic rats submitted to physical exercise.

Functional food mixtures: Inhibition of lipid peroxidation, HMGCoA reductase, and ACAT2 in hypercholesterolemia‐induced rats

“…Besides, lignoceric acid was classified as very long saturated fatty acids (VLSFA) found to be beneficial in improving metabolic disorders and cardiovascular diseases through weight gain control (Lee et al, 2015). Simvastatin (SVS) treatment at 10 mg/kg also involved in weight control but the mechanism of weight reduction was till unclearly defined because it mainly involved in the structural damage in muscles (Suzuki et al, 2018). ) between all groups.…”