O impacto da histologia do carcinoma pulmonar na frequência das metástases ósseas

Abstract

Objective Lung cancer is the leading cause of death by cancer, and the bones are one of the most common sites of metastasis from this condition. This study aimed to evaluate the influence of lung carcinoma histology on the frequency of bone metastases. Methods This retrospective study evaluated the medical records of 407 patients diagnosed with lung cancer between 2003 and 2012. The prevalence of bone metastases and their association with histological subtypes were evaluated using chi-squared tests, odds ratios (ORs) and 95% confidence intervals (CIs). The overall survival was evaluated using the Kaplan-Meier method. Results The prevalence of bone metastases was 28.2% ( n = 115), and the spine was the most frequently affected site (98 metastases; 32.1%). Adenocarcinoma was the most common histological subtype of lung carcinoma (46.7%), and it was significantly more frequent among patients with bone metastases (58.3% versus 42.1%; p = 0.003; OR = 1.92; 95% CI: 1.29–2.97). Squamous cell carcinoma was significantly less frequent among patients with bone metastases (13.0% versus 29.8%; p = 0.0004; OR = 0.35; 95% CI: 0.19–0.64). The median survival time after the first bone metastasis diagnosis was 4 months. Conclusion Adenocarcinoma was the most common histological subtype of lung carcinoma, and it was significantly associated with a higher risk of developing bone metastases.

Isolated distal ulnar bone metastasis from lung squamous cell carcinoma: an extremely rare case report

“…11,12 The three most commonly described locations of lung cancer metastases are the spine, pelvis, and femur. 13 Metastasis of primary lung cancer to the bone below the knee and elbow is very rare and requires a multidisciplinary team approach to establish the correct diagnosis and treatment. 14 Although bone metastases are common in patients with cancer, isolated ulnar metastases are extremely rare or have never been reported.…”

Pathological Fractures Due to Bone Metastases From Lung Cancer: Risk Factors and Survival

“…In previous studies conducted by Oliveira et al, adenocarcinoma was associated with the higher risk of developing BMs. 3 , 4 Therefore, we postulated that lung cancer histological subtype could also be correlated with the occurrence of PFs. In this study, we aimed to identify risk factors associated with the occurrence of PFs in patients with BMs from lung cancer and to assess the impact of this SRE on survival.…”