Lung age in women with morbid obesity

Abstract

Lung age is increased in morbidly obese women and is associated with increased body mass and BMI.

Overweight, Obesity, and Lung Function in Children and Adults—A Meta-analysis

“…FVC , the total volume of air exhaled with maximally forced effort from a maximal inspiration, reflects the total compliance from both the lung and chest wall. Similar to FEV 1 , overweight or obesity 24–28, 33, 34, 36, 37, 39, 40, 67 was negatively associated with FVC in adults, but there was no significant association in children. Likewise, our pooled analysis of studies reporting absolute FVC showed a slight increase in FVC in overweight 46, 66 or obese 15, 52, 66 children.…”

“…FEV 1 , the most frequently used spirometric index, is a function of airway resistance and total lung compliance. Overweight or obesity 12, 24, 25, 27, 28, 34–37, 39–42, 56, 58 was significantly associated with lower FEV 1 in the overall meta-analysis. However, the effect differed by age, with results driven by adults and no significant association in children.…”

“…In 30 studies included (n=16,913), percent-predicted FVC decreased by 2.2% [95% CI= −3.7 to −0.6%] among overweight/obese subjects compared to those of normal weight 15–18, 23–29, 32–34, 36, 37, 39, 40, 45, 46, 48, 50, 52–59 . The decrement was significant in adults (−4.6% [95% CI= −6.9 to −2.2%]) but not in children (Figure 3); and more pronounced among obese subjects (−3.2% [95% CI= −5.2 to −1.2%] than in overweight subjects (Supplemental Figure E3).…”

“…The decrement was more pronounced in children (−2.4%, [95% CI= −3.0 to −1.8%]) than in adults (−1.0% [95% CI= −1.4 to −0.6%]) (Figure 4); and it was similar in subjects with (−1.5% [95% CI= −1.9 to −1.0%]) and without asthma (−1.6% [95% CI= −2.3 to −0.8%]) (Table 1). When reviewing twelve studies that reported FEV 1 /FVC as percent of predicted, 10, 32, 33, 36, 37, 39, 44, 54, 56,58, 60, 72, 73 FEV 1 /FVC was lower among overweight/obese children (−1.7% [95% CI= −3.2 to −0.2%]) but slightly increased among overweight/obese adults (1.3% [95% CI= 0.01 to 2.6%], data not shown).…”

Improvement in lung function and functional capacity in morbidly obese women subjected to bariatric surgery

“…As a compensatory mechanism, IC increases to maintain vital capacity 31 . However, these volumes tend to normalize following weight loss 32 - 34 . Such findings are clinically relevant, as diminished ERV may determine a reduction in ventilation in the bases of the lungs, generating areas of pulmonary shunt due to the formation of atelectasis and sometimes resulting in hypoxemia 32 .…”