Glucosamine-conjugated graphene quantum dots as versatile and pH-sensitive nanocarriers for enhanced delivery of curcumin targeting to breast cancer

Ghanbari, Narges; Salehi, Zeinab; Khodadadi, Abbas Ali; Shokrgozar, Mohammad Ali; Saboury, Ali Akbar

doi:10.1016/j.msec.2020.111809

Cited by 36 publications

(15 citation statements)

References 76 publications

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“…The described system showed high cellular uptake, high in vitro and in vivo efficacy, and low toxicity. Glucosamine-conjugated GRQDs, showing a size of 20–30 nm and <10 layers, releasing after 150 h 37% and 17% of encapsulated CUR at pH 5.5 and pH 7.4, respectively, showed higher cellular internalization via glucosamine-receptor-mediated endocytosis in breast cancer cells as well as pronouncedly higher cytotoxicity against MCF-7 cells, compared to CUR/GRQDs [ 104 ]. Tryptophan-functionalized GRQDs were also characterized with high CUR-loading capacity and pH-sensitivity [ 105 ].…”

Section: Gbns As Drugs and Nanocarriersmentioning

confidence: 99%

Advances in Biologically Applicable Graphene-Based 2D Nanomaterials

Jampílek

Kráľová

2022

IJMS

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Climate change and increasing contamination of the environment, due to anthropogenic activities, are accompanied with a growing negative impact on human life. Nowadays, humanity is threatened by the increasing incidence of difficult-to-treat cancer and various infectious diseases caused by resistant pathogens, but, on the other hand, ensuring sufficient safe food for balanced human nutrition is threatened by a growing infestation of agriculturally important plants, by various pathogens or by the deteriorating condition of agricultural land. One way to deal with all these undesirable facts is to try to develop technologies and sophisticated materials that could help overcome these negative effects/gloomy prospects. One possibility is to try to use nanotechnology and, within this broad field, to focus also on the study of two-dimensional carbon-based nanomaterials, which have excellent prospects to be used in various economic sectors. In this brief up-to-date overview, attention is paid to recent applications of graphene-based nanomaterials, i.e., graphene, graphene quantum dots, graphene oxide, graphene oxide quantum dots, and reduced graphene oxide. These materials and their various modifications and combinations with other compounds are discussed, regarding their biomedical and agro-ecological applications, i.e., as materials investigated for their antineoplastic and anti-invasive effects, for their effects against various plant pathogens, and as carriers of bioactive agents (drugs, pesticides, fertilizers) as well as materials suitable to be used in theranostics. The negative effects of graphene-based nanomaterials on living organisms, including their mode of action, are analyzed as well.

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Section: Gbns As Drugs and Nanocarriersmentioning

confidence: 99%

Advances in Biologically Applicable Graphene-Based 2D Nanomaterials

Jampílek

Kráľová

2022

IJMS

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“…Complexes that include photoluminescent graphene quantum dots with glucosamine as a targeting agent, and with curcumin as an anticancer agent, have been proven to inhibit cells of the MCF-7 breast cancer line, a result that sounds promising due to the observed behavior pH-sensitive, sustained release for nano-assembly (25). Graphitic carbon nitride (g-C3N4) Quantum Dots synthesized through the usual calcination method served as nanoplatforms for dual two-photon excited photodynamic therapy (TPE-PDT) and two-photon imaging (TPI) (26).…”

Section: Graphene In Breast Cancermentioning

confidence: 99%

Nanomaterials for Breast Cancer

Orrantia‐Borunda¹,

Acuña-Aguilar²,

Ramírez-Valdespino³

2022

Breast Cancer

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Breast cancer represents 16% of all malignant tumors diagnosed and is the leading cause of mortality in women worldwide. While significant advances in the diagnosis and treatment of breast cancer have been made over the years, the management of advanced stages of the disease and treatment-related adverse events continue to be a challenge. There is a need to develop tools for target-specific delivery of drugs to improve efficiency and decrease non-specific drug-induced Note to the Reader: This chapter is part of the book Breast Cancer (ISBN: 978-0-6453320-3-2), scheduled for publication in July 2022. The book is being published by Exon Publications,

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“…Glucose and GlcN are delivered to cells via various glucose transporters (GLUTs) and sodium glucose transporters (SGLTs) expressed on cell membranes [9,16], many of which are overexpressed on tumor cells to facilitate glucose and GlcN delivery [17]. Owing to the aforementioned higher GlcN demand by tumor cells than by normal cells (GlcN effects) and the -NH 2 group of GlcN, which allows easy conjugation with the -COOH group of functional agents via an amide bond (-OH group of glucose is not easy for conjugation), GlcN has been widely applied as a conjugation ligand to increase delivery amounts of antitumor drugs [18][19][20][21], tumor imaging agents [21][22][23], and tumor therapeutic agents [24]. GlcN had been conjugated with various materials for drug delivery to tumor, tumor imaging, and tumor therapy.…”

Section: Introductionmentioning

confidence: 99%

“…GlcN had been conjugated with various materials for drug delivery to tumor, tumor imaging, and tumor therapy. These included poly(amidoamine) dendrimers to deliver camptothecin antitumor drug to human lung tumor (A549) cells in vitro and in vivo [18], graphene quantum dots to deliver curcumin antitumor drug to human breast tumor (MCF-7) cells in vitro [19], niosomal formulation to deliver doxorubicin antitumor drug to skin melanoma tumor (B6F10) cells in vitro [20], InP/ZnS quantum dots to deliver doxorubicin to human lung epithelial tumor (A549) cells and human ovarian tumor (OVCAR-3) cells in vitro and to image tumor cells [21], near infrared fluorescent probes for breast [22] and prostate [23] tumor imaging in vitro and in vivo, and multifunctional doxorubicin loaded gadolinium/cobalt@iron oxide-dendrimer-nanoseeds for chemo-magneto hyperthermia treatment of human prostate tumor (PC3) cells in vitro [24].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Tumor Imaging Using Glucosamine-Conjugated Polyacrylic Acid-Coated Ultrasmall Gadolinium Oxide Nanoparticles in Magnetic Resonance Imaging

Liu

Yue

et al. 2022

IJMS

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Owing to a higher demand for glucosamine (GlcN) in metabolic processes in tumor cells than in normal cells (i.e., GlcN effects), tumor imaging in magnetic resonance imaging (MRI) can be highly improved using GlcN-conjugated MRI contrast agents. Here, GlcN was conjugated with polyacrylic acid (PAA)-coated ultrasmall gadolinium oxide nanoparticles (UGONs) (davg = 1.76 nm). Higher positive (brighter or T1) contrast enhancements at various organs including tumor site were observed in human brain glioma (U87MG) tumor-bearing mice after the intravenous injection of GlcN-PAA-UGONs into their tail veins, compared with those obtained with PAA-UGONs as control, which were rapidly excreted through the bladder. Importantly, the contrast enhancements of the GlcN-PAA-UGONs with respect to those of the PAA-UGONs were the highest in the tumor site owing to GlcN effects. These results demonstrated that GlcN-PAA-UGONs can serve as excellent T1 MRI contrast agents in tumor imaging via GlcN effects.

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Glucosamine-conjugated graphene quantum dots as versatile and pH-sensitive nanocarriers for enhanced delivery of curcumin targeting to breast cancer

Cited by 36 publications

References 76 publications

Advances in Biologically Applicable Graphene-Based 2D Nanomaterials

Advances in Biologically Applicable Graphene-Based 2D Nanomaterials

Nanomaterials for Breast Cancer

Enhanced Tumor Imaging Using Glucosamine-Conjugated Polyacrylic Acid-Coated Ultrasmall Gadolinium Oxide Nanoparticles in Magnetic Resonance Imaging

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