Mitochondrial adaptation in steatotic mice

Einer, Claudia; Hohenester, Simon; Wimmer, Ralf; Wottke, Lena; Artmann, Renate; Schulz, Sabine; Gosmann, Christian; Simmons, Alisha; Leitzinger, Christin; Eberhagen, Carola; Borchard, Sabine; Schmitt, Sabine; Hauck, Stefanie M.; Toerne, Christine von; Jastroch, Martin; Walheim, Ellen; Rust, Christian; Gerbes, Alexander L.; Popper, Bastian; Mayr, Doris; Schnurr, Max; Vollmar, Angelika M.; Denk, Gerald; Zischka, Hans

doi:10.1016/j.mito.2017.08.015

Cited by 53 publications

(59 citation statements)

References 50 publications

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“…Increase in serum TBARS and nitrite/nitrate in steatosis (group 2) animals proves contributions of ROS and RNS in the development of NASH (group 3). Current findings are in agreement with previous research findings (Alcala et al, ; Einer et al, ). Furthermore we also observed increased mitochondrial ROS and serum nitrite/nitrate in steatosis and NASH animals.…”

Section: Discussionsupporting

confidence: 94%

Protective role of germinated mung bean against progression of non-alcoholic steatohepatitis in rats: A dietary therapy to improve fatty liver health

2018

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The current research was focused at investigating the different doses of germinated mung bean (GMB) (Vigna Radiata [Fabaceae]) on progression of non‐alcoholic steatohepatitis (NASH) from steatosis. Beneficial effects of GBM against NASH from steatosis‐induced liver injury were apparent from decreased serum transaminase activities, lipid peroxidation and nitrite/nitrate contents, and recoupment of glutathione. Enzymatic antioxidants were inclined toward normal in high dose GMB supplemented rats. On the other hand low dose of GMB prevented further alteration when compared with steatosis. Gene expression analysis shows that supplementation of GMB restores the antioxidant enzyme gene expressions. GMB effect was confirmed through histopathological observation, which is correlated along with lipid reduction and various inflammatory cytokine restoration. Further GMB could abrogate alleviated mitochondrial ROS generation. In summary, GMB has a huge potential to decrease the consequence of oxidative stress, which could be one of the contributing mechanism to its protective effect in attenuating the progression of NASH. Practical applications Mung bean is widely consumed world‐wide by all the population. Germinated mung bean prevents development of steatohepatitis from steatosis. Higher consummation may be recommended for their betterment of liver health.

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Section: Discussionsupporting

confidence: 94%

Protective role of germinated mung bean against progression of non-alcoholic steatohepatitis in rats: A dietary therapy to improve fatty liver health

2018

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“…The combination of fructose and a HF diet induced an increase in weight gain and steatosis in mice after 8 weeks of feeding compared to a pure HF diet. An extension of feeding up to 16 weeks with this combined diet resulted in significant inflammation in the liver but not in an increase in liver damage [165,166]. Similar results were found with a 15-week sucrose-supplemented HF diet: it increased body weight gain, liver TG values, steatosis values and TNF-a values compared to the pure HF diet.…”

Section: Western Dietssupporting

confidence: 73%

“…Alterations in the structure of mitochondria along with changes in mitochondrial metabolism have been reported in several models of NAFLD [165,190,191]. Although the mechanisms of NAFLD development and progression are still not completely understood, a causative link has been addressed between mitochondrial dysfunction and exacerbated oxidative stress in the pathophysiology of steatosis and progression to NASH [192].…”

Section: Mitochondrial Metabolic Dysfunction In Nafldmentioning

confidence: 99%

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Fat and Sugar—A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease

et al. 2019

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Nonalcoholic fatty liver disease (NAFLD) is a common disease in Western society and ranges from steatosis to steatohepatitis to end-stage liver disease such as cirrhosis and hepatocellular carcinoma. The molecular mechanisms that are involved in the progression of steatosis to more severe liver damage in patients are not fully understood. A deeper investigation of NAFLD pathogenesis is possible due to the many different animal models developed recently. In this review, we present a comparative overview of the most common dietary NAFLD rodent models with respect to their metabolic phenotype and morphological manifestation. Moreover, we describe similarities and controversies concerning the effect of NAFLD-inducing diets on mitochondria as well as mitochondria-derived oxidative stress in the progression of NAFLD.

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“…Proteomic data of isolated liver mitochondria from ND and WD fed mice by mass spectrometry.Data source locationMunich, GermanyData accessibilityRelated researcharticleData are available with this article.Einer et al “Mitochondrial adaptation in steatotic mice”, Mitochondrion, 2017 (in press). [1]…”

mentioning

confidence: 99%

Data on chow, liver tissue and mitochondrial fatty acid compositions as well as mitochondrial proteome changes after feeding mice a western diet for 6–24 weeks

Einer

Hohenester²,

Wimmer³

et al. 2017

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The data presented in this article describe the fatty acid composition of chow, liver tissue and isolated liver mitochondria from mice fed for 6–24 weeks with a high caloric western diet (WD) in comparison to control diet (normal diet, ND). The fatty acid composition was measured via gas chromatography flame ionization detection (GC-FID). Moreover, WD-induced mitochondrial protein changes are presented in this work and were analyzed by mass spectrometry (LC–MS/MS). For further interpretation and discussion of the presented data please refer to the research article entitled “Mitochondrial adaptation in steatotic mice” (Einer et al., 2017) [1].

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Mitochondrial adaptation in steatotic mice

Cited by 53 publications

References 50 publications

Protective role of germinated mung bean against progression of non-alcoholic steatohepatitis in rats: A dietary therapy to improve fatty liver health

Protective role of germinated mung bean against progression of non-alcoholic steatohepatitis in rats: A dietary therapy to improve fatty liver health

Fat and Sugar—A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease

Data on chow, liver tissue and mitochondrial fatty acid compositions as well as mitochondrial proteome changes after feeding mice a western diet for 6–24 weeks

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