Newborns at high risk for brain injury: the role of the amplitude-integrated electroencephalography

Variane, Gabriel Fernando Todeschi; Rodrigues, Daniela Pereira; Pietrobom, Rafaela Fabri Rodrigues; França, Carolina Nunes; Netto, Alexandre; Magalhães, Maurício

doi:10.1016/j.jped.2021.10.008

Cited by 7 publications

(5 citation statements)

References 65 publications

(114 reference statements)

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“…Concomitant recording of 5-channel EEG has shown that some short seizures, some focal discharges, or continuous peak discharges can be ignored when reading aEEG [16]. Some studies show that using two-channel aEEG, combined with the raw EEG path on the same monitor, improved the accuracy of interpretation [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

The Role of Amplitude-Integrated Electroencephalography (aEEG) in Monitoring Infants with Neonatal Seizures and Predicting Their Neurodevelopmental Outcome

Doandes,

Manea,

Lungu

et al. 2023

Children

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Newborn monitoring in neonatal intensive care units (NICU) is mandatory, but neurological and especially electroencephalographic (EEG) monitoring can be overlooked or delayed until the newborn is clinically stable. However, the neonatal period is associated with the highest risk of seizures in humans, and the clinical symptoms may often be discrete, but the evolution and long-term neurodevelopmental disorders in these patients may be important. In response to this issue, we conducted a study to evaluate newborns who experienced neonatal seizures (NS) in the NICU and monitored their long-term neurological development. We enrolled 73 term and preterm newborns who underwent EEG monitoring using amplitude-integrated electroencephalography (aEEG). We then followed their neurological development until around 18 months of age, with 59 patients remaining in the long-term study. A total of 22% of patients with NS developed epilepsy, 12% cerebral palsy, 19% severe neurodevelopmental disabilities, and 8.5% died within the first 18 months of life. Our findings indicate that aEEG background pattern is a strong predictor of unfavorable neurological outcomes, with an odds ratio of 20.4174 (p < 0.05). Additionally, higher Apgar scores were associated with better outcomes (p < 0.05), with the odds of unfavorable neurological outcomes decreasing by 0.7-fold for every point increase in Apgar score. Furthermore, we found a statistically significant association between preterm birth and unfavorable neurological outcomes (p = 0.0104). Our study highlights the importance of early EEG monitoring in the NICU and provides valuable insights into predictors of unfavorable neurological outcomes in newborns who experienced NS.

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Section: Introductionmentioning

confidence: 99%

The Role of Amplitude-Integrated Electroencephalography (aEEG) in Monitoring Infants with Neonatal Seizures and Predicting Their Neurodevelopmental Outcome

Doandes,

Manea,

Lungu

et al. 2023

Children

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show abstract

“…To achieve continuous and convenient monitoring, researchers have developed and promoted amplitude-integrated EEG (aEEG), which can be recorded and interpreted independently by observers without expert knowledge. Amplitude-integrated EEGs have been applied in many areas to recognize neonatal brain functional state [2][3], and gained much attention in clinical over the past decades. Nevertheless, research on computer-aided automatic analysis of aEEGs is still at the early stages.…”

Section: Introductionmentioning

confidence: 99%

Multi-scale transformation-based image representation and analysis of amplitude-integrated EEG

Wu,

Chen,

2023

Second International Conference on Biomedical and Intelligent Systems (IC-BIS 2023)

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“…Cerebral monitoring of the aEEG trend for seizure detection and evaluation of cortical activity, e.g., the presence of sleep-wake cycling is routinely performed in the NICU [ 16 , 17 , 18 , 19 ]. While aEEG is effective for a general qualitative clinical bedside assessment, the aEEG interpretation is still a subjective assessment with a substantial inter-rater variation and consequently poor sensitivity to those effects that may accompany drug treatment or other therapeutic maneuvers [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

A Bedside Method for Measuring Effects of a Sedative Drug on Cerebral Function in Newborn Infants

Nilsson

Tokariev

Metsäranta

et al. 2022

Sensors

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Background: Data on the cerebral effects of analgesic and sedative drugs are needed for the development of safe and effective treatments during neonatal intensive care. Electroencephalography (EEG) is an objective, but interpreter-dependent method for monitoring cortical activity. Quantitative computerized analyses might reveal EEG changes otherwise not detectable. Methods: EEG registrations were retrospectively collected from 21 infants (mean 38.7 gestational weeks; range 27–42) who received dexmedetomidine during neonatal care. The registrations were transformed into computational features and analyzed visually, and with two computational measures quantifying relative and absolute changes in power (range EEG; rEEG) and cortico-cortical synchrony (activation synchrony index; ASI), respectively. Results: The visual assessment did not reveal any drug effects. In rEEG analyses, a negative correlation was found between the baseline and the referential frontal (rho = 0.612, p = 0.006) and parietal (rho = −0.489, p = 0.035) derivations. The change in ASI was negatively correlated to baseline values in the interhemispheric (rho = −0.753; p = 0.001) and frontal comparisons (rho = −0.496; p = 0.038). Conclusion: Cerebral effects of dexmedetomidine as determined by EEG in newborn infants are related to cortical activity prior to DEX administration, indicating that higher brain activity levels (higher rEEG) during baseline links to a more pronounced reduction by DEX. The computational measurements indicate drug effects on both overall cortical activity and cortico-cortical communication. These effects were not evident in visual analysis.

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Newborns at high risk for brain injury: the role of the amplitude-integrated electroencephalography

Cited by 7 publications

References 65 publications

The Role of Amplitude-Integrated Electroencephalography (aEEG) in Monitoring Infants with Neonatal Seizures and Predicting Their Neurodevelopmental Outcome

The Role of Amplitude-Integrated Electroencephalography (aEEG) in Monitoring Infants with Neonatal Seizures and Predicting Their Neurodevelopmental Outcome

Multi-scale transformation-based image representation and analysis of amplitude-integrated EEG

A Bedside Method for Measuring Effects of a Sedative Drug on Cerebral Function in Newborn Infants

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