Association between exposure to pesticides and allergic diseases in children and adolescents: a systematic review with meta-analysis

Rodrigues, Marina De Barros; Carvalho, Denise Siqueira de; Chong-Silva, Débora Carla; Urrutia-Pereira, Marilyn; Albuquerque, Guilherme Souza Cavalcanti de; Cieslak, Fabrício; Chong-Neto, Herberto José

doi:10.1016/j.jped.2021.10.007

Cited by 16 publications

(19 citation statements)

References 33 publications

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“…More recently, a 2022 systematic review found similar limitations among studies on the association between pesticide exposure and CRS . In fact, both reviews found few to no studies differentiating among CRS subtypes (ie, CRSwNP and CRSwoNP) in their analyses …”

Section: Discussionmentioning

confidence: 96%

“…33 In fact, both reviews found few to no studies differentiating among CRS subtypes (ie, CRSwNP and CRSwoNP) in their analyses. 18,33 The present study was, to our knowledge, the first to investigate the association between residential pesticide exposure and risks for CRS. Rather than relying on self-reported data, the determination of CRS status was based on clinical history and objective evidence of sinonasal inflammation per endoscopy and/or imaging results in accordance with the diagnostic guidelines for CRS diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…More recently, a 2022 systematic review found similar limitations among studies on the association between pesticide exposure and CRS. 33 In fact, both reviews found few to no studies differentiating among CRS subtypes (ie, CRSwNP and CRSwoNP) in their analyses. 18,33 The present study was, to our knowledge, the first to investigate the association between residential pesticide exposure and risks for CRS.…”

Section: Discussionmentioning

confidence: 99%

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Residential Proximity to a Commercial Pesticide Application Site and Risk of Chronic Rhinosinusitis

Yang

Paul

Cockburn

et al. 2023

JAMA Otolaryngol Head Neck Surg

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ImportanceEnvironmental and occupational toxicants have been shown to be associated with an increased prevalence of chronic rhinosinusitis (CRS). However, few to no studies have evaluated patients for CRS using objective testing and workup protocols that fulfill guidelines for CRS diagnostic criteria. Furthermore, no study, to our knowledge, has investigated the risks of CRS in the context of residential exposure through proximity to a commercial pesticide application site.ObjectivesTo evaluate associations of residential proximity to a commercial pesticide application site and the prevalence of CRS with nasal polyps (CRSwNP) and without nasal polyps (CRSwoNP).Design, Setting, and ParticipantsThis was a retrospective cohort study of patients who presented to a tertiary care institution for rhinology evaluation between March 1, 2018, and December 31, 2022.Main Outcomes and MeasuresThe outcome variable was the clinical diagnosis of CRS (CRSwNP, CRSwoNP, or non-CRS control). Patients’ residential addresses were utilized to determine pesticide exposure status based on a validated computational geographic information algorithm based on data from the California Pesticide Use Report System. The dichotomous independent variable of exposure status (exposed or non-exposed) was determined by assessing reports of any pesticide applications within 2000 m of each participant’s residence in 2017. Multivariable logistic regressions assessing CRS status and CRS subtypes were conducted with pesticide exposure as the primary covariate of interest. The primary study outcome and measurements as well as study hypothesis were all formulated before data collection.ResultsAmong a total of 310 patients (90 CRSwNP, 90 CRSwoNP, and 130 control), the mean (SD) age was 50 (17) years; 164 (53%) were female. Race and ethnicity information was not considered. Controlling for patient demographic information, smoking history, county of residence, and medical comorbidities, pesticide exposure was associated with an approximately 2.5-fold increase in odds of CRS (adjusted odds ratio, 2.41; 95% CI, 1.49-3.90). Pesticide exposure was associated with similar risks for CRSwNP (adjusted relative risk ratio [aRRR], 2.34; 95% CI, 1.31-4.18) and CRSwoNP (aRRR, 2.42; 95% CI, 1.37-4.30).Conclusions and RelevanceThe findings of this retrospective cohort study and analysis revealed that residential exposure to commercial pesticide application within a 2000-m buffer was independently associated with an approximately 2.5-fold increase in odds of being diagnosed with CRS. If validated by additional research, this association would have substantial implications for public health.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Residential Proximity to a Commercial Pesticide Application Site and Risk of Chronic Rhinosinusitis

Yang

Paul

Cockburn

et al. 2023

JAMA Otolaryngol Head Neck Surg

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“…15 Some pesticides may alter hormone action by behaving as endocrine disruptors, altering development and reproduction, 22 and increasing the risk for asthma or exacerbations in children and adolescents. 29 In rural areas, the burning of agricultural residues and certain agroforestry activities also cause air pollution. Indoor air pollution remains a major threat, affecting approximately 2.45 billion people in low-and middle-income countries due to exposure to biomass burning for cooking.…”

Section: Discussionmentioning

confidence: 99%

Environmental history-taking as part of pediatric consultations: a pilot study

et al. 2022

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Introduction. Children's environmental health studies the influence of the environment on health and disease in children. Global environmental exposures pose a serious threat to health, warranting further research and action.Objective. To assess the environmental health of a sample of children living in urban and rural areas in Uruguaiana, Brazil.Population and methods. We included parents/legal guardians (n = 714) of children seen at Policlinica Infantil de Uruguaiana between January and October 2021, who completed the environmental historytaking in pediatrics (Brazilian Society of Pediatrics). Collected data were analyzed based on place of residence (urban or rural) or household income.Results. The comparison between inhabitants of the urban area (n = 660) and the rural area (n = 54) established that, among those living in the rural area, activity with chemical substances (15% versus 32.7%; p = 0.004), living near a plantation (7.5% versus 74.5%; p < 0.001) or near a source of contamination (4.8% versus 32.7%; p < 0.001), having a dog (62% versus 87.3%; p < 0.001), using pesticides (0.6% versus 32.7%; p < 0.001), and exposure to chemical contamination (2.6% versus 18.2%; p < 0.001) were significantly higher. In the urban area, exposure to vehicle traffic near the house (85% versus 48.1%; p < 0.001), an average income below 3 minimum wages (90%), and a low level of education predominated. Conclusion.Environmental history-taking is critical for the detection of environmental threats present in the areas where children and adolescents live, learn, play, and study.

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“…15 Algunos pesticidas pueden alterar la acción de las hormonas al comportarse como disruptores endocrinos, alterando el desarrollo y la reproducción, 22 y aumentando el riesgo de desarrollar o exacerbar el asma en niños y adolescentes. 29 En las zonas rurales, la quema de residuos agrícolas y ciertas actividades agroforestales también provocan contaminación del aire. La contaminación del aire interior sigue siendo una gran amenaza, ya que afecta a aproximadamente 2450 millones de personas en países de ingresos medios y bajos, debido a la exposición a la quema de biomasa para cocinar.…”

Section: Discussionunclassified

Anamnesis ambiental como parte de la consulta pediátrica: estudio piloto

2022

Arch Argent Pediat

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Association between exposure to pesticides and allergic diseases in children and adolescents: a systematic review with meta-analysis

Cited by 16 publications

References 33 publications

Residential Proximity to a Commercial Pesticide Application Site and Risk of Chronic Rhinosinusitis

Residential Proximity to a Commercial Pesticide Application Site and Risk of Chronic Rhinosinusitis

Environmental history-taking as part of pediatric consultations: a pilot study

Anamnesis ambiental como parte de la consulta pediátrica: estudio piloto

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