Prevalence of Epstein-Barr Viral DNA among children at a single hospital in Suzhou, China

Shi, Ting; Huang, Lijie; Tian, Jianmei

doi:10.1016/j.jped.2021.05.006

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…Primary EBV infection can cause obvious allergic diseases. Once human B cells are transformed by EBV, they will be autocrine to produce IL-5 and induce chronic eosinophilic inflammatory response, and it will also produce IL-4, which stimulates the production and proliferation of human IgE antibodies [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Investigation on the Correlation between Serum Immune Factor Levels and Allergic Constitution in Children with Infectious Mononucleosis

Sun

Wang

Lin

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the correlation between serum immune factor levels and allergic constitution in children with infectious mononucleosis. Methods. A total of 120 children who visited our hospital from March, 2019, to December, 2020, were selected as the research objects, and 40 children who came to our hospital for physical examination were included in the control group (CG). 40 children with IM were classified into the IM group (IG), and 40 IM children with allergic rhinitis, allergic dermatitis, asthma, and other allergic diseases were classified into the IM allergy group (AG). On the second day of admission, 5 ml of fasting venous blood was collected from all children in the early morning to observe the serum IgE level, the level of lymphocyte subsets, and the level of immunoglobulin of the patient. Results. The serum CD3, CD4, and CD8 levels of children in AG were significantly higher than those in IG and CG ( P < 0.05 ). The serum IgE, IgA, IgM, and IgG levels of children in AG were significantly higher than those of IG and CG ( P < 0.05 ). The serum IgE levels of children in AG were positively correlated with the serum CD3, CD4, and CD8 levels ( P < 0.05 ). There was a positive correlation between the serum IgE level and serum IgA, IgM, and IgG levels in children with AG ( P < 0.05 ). Conclusion. The results of this study showed that there may be a certain relationship between allergic constitution and the incidence, clinical manifestations, and prognosis of infectious mononucleosis. IgE level can be used as a reference index for the early severity of IM clinical symptoms.

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Section: Discussionmentioning

confidence: 99%

Investigation on the Correlation between Serum Immune Factor Levels and Allergic Constitution in Children with Infectious Mononucleosis

Sun

Wang

Lin

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Previous study showed that EBV positive rate was the lowest at 0-1 year, then increased gradually in the older groups, EBV seroprevalence became more than 50% before age 3 in Chinese children ( Xiong et al., 2014 ; Shi et al., 2022 ). Our study also confirmed that the constituent ratios of EBV infection was lowest in infants aged no more than 1 year old.…”

Section: Discussionmentioning

confidence: 94%

“…Our study also confirmed that the constituent ratios of EBV infection was lowest in infants aged no more than 1 year old. Primary EBV infection has been considered common in younger children, and mainly occurred in Chinese children at 2-4 years old ( Garcia-Peris et al., 2019 ; Shi et al., 2022 ). In this study, EBV ratios among children aged >10 y showed a noticeable increase from 2017 to 2022, whereas the ratios of patients aged 3-5 y was reduced slightly during 2017 to 2022.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and clinical characteristics of Epstein-Barr virus infection among children in Shanghai, China, 2017-2022

Chen

Zhong

et al. 2023

Front. Cell. Infect. Microbiol.

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ObjectiveTo investigate the epidemiology and infectious characteristics of Epstein-Barr virus (EBV) infection among children in Shanghai, China from 2017 to 2022.MethodsWe conducted a retrospective analysis of 10,260 inpatient patients who were subjected EBV nucleic acid testing from July 2017 to December 2022. Demographic information, clinical diagnosis, laboratory findings, etc. were collected and analyzed. EBV nucleic acid testing were performed by real-time PCR.ResultsA total of 2192 (21.4%) inpatient children were EBV-positive, with the average age of 7.3 ± 0.1 y. EBV detection was stable from 2017 to 2020 (26.9~30.1%), but showed essential decreases in 2021 (16.0%) and 2022 (9.0%). EBV was highest (>30%) detected from three quarters (Q) including 2018-Q4, 2019-Q4 and 2020-Q3. There were 24.5% of EBV coinfection with other pathogens, including bacteria (16.8%), other viruses (7.1%) and fungi (0.7%). EBV viral loads increased when coinfecting with bacteria ((142.2 ± 40.1) ×104/mL) or other viruses ((165.7 ± 37.4) ×104/mL). CRP significantly increased in EBV/fungi coinfection, while procalcitonin (PCT) and IL-6 showed remarkable increases in EBV/bacteria coinfection. Most (58.9%) of EBV-associated diseases belonged to immune disorders. The primary EBV-related diseases were systemic lupus erythematosus (SLE, 16.1%), immunodeficiency (12.4%), infectious mononucleosis (IM, 10.7%), pneumonia (10.4%) and Henoch-schonlein purpura (HSP, 10.2%). EBV viral loads were highest ((233.7 ± 27.4) × 104/mL) in patients with IM.ConclusionEBV was prevalent among children in China, the viral loads increased when coinfecting with bacteria or other viruses. SLE, immunodeficiency and IM were the primary EBV-related diseases.

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“…In terms of the at-risk age of onset, our results showed that children hospitalized for IM were mainly 4–6 years old in China, which was similar to the data analyzed by the single-center study of hospitalized IM children ( Gao et al., 2011 ; Hu et al., 2021 ). In China and other developing countries of Asia and Africa, most primary EBV infections occur in children, especially preschoolers, who make up a large portion of IM patients ( Dunmire et al., 2015 ; Shi et al., 2022 ). However, in developed countries, such as Western countries, the peak age of IM is mostly in adolescence and adulthood ( Dunmire et al., 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Epidemiological characteristics and disease burden of infectious mononucleosis in hospitalized children in China: A nationwide retrospective study

Liu¹,

Wang²,

Zhang³

et al. 2022

Virologica Sinica

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Prevalence of Epstein-Barr Viral DNA among children at a single hospital in Suzhou, China

Cited by 6 publications

References 16 publications

Investigation on the Correlation between Serum Immune Factor Levels and Allergic Constitution in Children with Infectious Mononucleosis

Investigation on the Correlation between Serum Immune Factor Levels and Allergic Constitution in Children with Infectious Mononucleosis

Epidemiology and clinical characteristics of Epstein-Barr virus infection among children in Shanghai, China, 2017-2022

Epidemiological characteristics and disease burden of infectious mononucleosis in hospitalized children in China: A nationwide retrospective study

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