Intra- and interobserver agreement of histopathological findings in pediatric patients with eosinophilic esophagitis

Vieira, Mário César; Gugelmin, Elizabeth Schneider; Percicote, Ana Paula; Ribeiro, Melyssa Grignet; Miranda, Renata Augusta de; Vieira, Gabriela Guimarães; Ribeiro, Luciana Bandeira Mendez; Truppel, Sabine Krüger; Filho, Nelson Augusto Rosário

doi:10.1016/j.jped.2021.03.004

Cited by 9 publications

(12 citation statements)

References 22 publications

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“…7 With respect to intra- and inter-observer agreement for items specifically on this scale, most of items, apart from BZH, revealed substantial and excellent agreement among experienced pathologists in the diagnosis of EoE (κ = .62–.94, ICC = .90–.94). 25 At our institution, the main challenge associated with the EoE HSS included its demand on time and added labor. However, given the system’s complexity and comprehensiveness, its potential value should not be overlooked.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Prognostic Implication of the Collins Histology Scoring System in a Pediatric Eastern Ontario Population With Eosinophilic Esophagitis

et al. 2022

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Introduction: Collins et al developed a histology scoring system (EoE HSS) to assess multiple pathologic features. The aim of this study is to identify if the EoE HSS can better detect endoscopic and symptom improvement vs the Peak Eosinophilic Count (PEC). Methods: A retrospective chart review was performed for patients during 2014–2016. All patients ≤18 years old with a diagnosis of EoE and whose records included initial and follow-up upper gastrointestinal endoscopies were included. Severity and extent of endoscopic features were scored using 8 parameters, from normal to maximum change for each location of the esophageal biopsy. Results: Forty patients with EoE were included in the study, of which 35 (87.5%) patients demonstrated symptom and 25 (62.5%) endoscopic improvement at the time of follow-up. In the proximal esophagus, the EoE HSS outperformed the change in eosinophil count of the Children’s Hospital of Eastern Ontario (CHEO) practice in predicting endoscopic improvement by 16.8% when examining the change in grade and 17.1% when examining the change in stage scores. Conclusions: At our institution, adoption of the EoE HSS in assessing biopsies of EoE patients might be warranted, compared to the traditional practice. However, a bigger sample size may give a more robust difference in all locations.

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Section: Discussionmentioning

confidence: 99%

Evaluating the Prognostic Implication of the Collins Histology Scoring System in a Pediatric Eastern Ontario Population With Eosinophilic Esophagitis

et al. 2022

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“…Vieira et al. 4 explored how different pathologist expertise may influence the identification of the eosinophilic infiltration and additional histological changes included in the eosinophilic esophagitis histologic scoring system (EoEHSS). Fifty esophageal biopsies from pediatric patients with EoE were analyzed by pathologists with high or low experience, after being considered adequate samples from the most expert one.…”

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confidence: 99%

“…Fifty esophageal biopsies from pediatric patients with EoE were analyzed by pathologists with high or low experience, after being considered adequate samples from the most expert one. 4 …”

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confidence: 99%

“…The agreement was excellent for identifying the EoE diagnostic cut-off score of ≥ 15 eosinophils / HPF whereas it was poor for other individual items of EoEHSS, particularly among the least experienced pathologists. 4 Based on their results, the authors suggest that specific training of pathologists is required for the correct identification of all EoEHSS features that may be useful in the evaluation of response to treatment and in the correlation with clinical manifestations and endoscopic findings. 4 …”

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confidence: 99%

“… 4 Based on their results, the authors suggest that specific training of pathologists is required for the correct identification of all EoEHSS features that may be useful in the evaluation of response to treatment and in the correlation with clinical manifestations and endoscopic findings. 4 …”

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confidence: 99%

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