Growth hormone deficiency and the transition from pediatric to adult care

Tavares, Ana Beatriz Winter; Collett‐Solberg, Paulo Ferrez

doi:10.1016/j.jped.2021.02.007

Cited by 2 publications

(1 citation statement)

References 53 publications

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“…Ключевую роль в диагностике недостаточности ГР играют провокационные пробы. Измерение суточной спонтанной секреции ГР оправдано в случае, когда наблюдается субнормальная скорость роста наряду с нормальными результатами стимуляционных тестов [18]. Подобная ситуация отражает легкую степень повреждения соматотрофов в результате воздействия малых доз облучения (20-30 Гр) наряду с неадекватной функцией гипоталамуса (нейросекреторная дисфункция ГР).…”

Section: диагностика дефицита гормона ростаunclassified

Growth hormone deficiency in childhood brain tumors and acute lymphoblastic leukemia survivors

et al. 2022

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Thanks to modern treatment protocols, childhood cancer survivors (CCS) are a very fast-growing population nowadays. Cancer therapy inevitably leads to different late adverse effects, where endocrine disorders are highly prevalent, including growth hormone deficiency (GHD) which is the most common endocrine outcome after cancer treatment in childhood and contributes to impaired growth. Short stature is a big issue, which leads to problems in psychological and social adaptation of patients and reduces their quality of life. Impact of GH treatment on various physiological processes and global outcome of CCS is of great interest. Several studies have demonstrated an influence of GH and IGF-1 on the development/tumour growth, cell proliferation. In this regard, the issue of increasing the risk of cancer recurrence and/or the development of secondary neoplasms in CCS, causes a lot of controversy and is the subject of continuous evaluation. In this review, we went through the available data on the prevalence and pathogenesis of GHD following chemo- and radiotherapy, in particular after treatment of brain tumors and acute lymphoblastic leukaemia in childhood. In addition, here we discuss the existing problems in the diagnosis of GHD, the safety of GH replacement therapy, as well as the treatment algorithm of the GHD in adults.

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Section: диагностика дефицита гормона ростаunclassified

Growth hormone deficiency in childhood brain tumors and acute lymphoblastic leukemia survivors

et al. 2022

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Management of childhood-onset growth hormone deficiency in patients transitioning from pediatric to adult care: A review of the literature and consensus report from a panel of experts in Saudi Arabia

AlMutair,

Alsagheir,

AlShammary

et al. 2023

International Journal of Pediatrics and Adolescent Medicine

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Despite increased recognition of the importance of optimizing care for patients with childhood-onset growth hormone deficiency (CO-GHD) during the transition period from pediatric to adult services, its implementation in clinical practice in Saudi Arabia remains challenging. By an initiative from the Saudi Society of Endocrinology and Metabolism, a panel comprising 11 experts, including both pediatric and adult endocrinologists with practical experience in the clinical management of patients with CO-GHD, was convened to discuss issues relating to transition care in this patient population. The primary objective of this consensus document was to develop the first clinician-led consensus statement that establishes best practices when transitioning adolescents with persistent CO-GHD to adult care in Saudi Arabia. A modified Delphi method was applied to develop consensus statements. A literature review was performed, and 20 statements were subsequently formulated. After two rounds of Delphi, consensus was achieved for 18 of the 20 statements.

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Growth hormone deficiency and the transition from pediatric to adult care

Cited by 2 publications

References 53 publications

Growth hormone deficiency in childhood brain tumors and acute lymphoblastic leukemia survivors

Growth hormone deficiency in childhood brain tumors and acute lymphoblastic leukemia survivors

Management of childhood-onset growth hormone deficiency in patients transitioning from pediatric to adult care: A review of the literature and consensus report from a panel of experts in Saudi Arabia

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