Rational use of antimicrobials in the treatment of upper airway infections

Miguélez, Santiago Alfayate; García‐Marcos, Luis

doi:10.1016/j.jped.2019.11.001

Cited by 10 publications

(6 citation statements)

References 57 publications

(97 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, effective communication between physicians and caregivers are also essential. This will help physicians and caregivers to enhance their mutual understanding, improve caregivers’ satisfaction and trust in physicians, and reduce prescription pressure from caregivers 18 56 57…”

Section: Discussionmentioning

confidence: 99%

Antibiotic prescription for children with acute respiratory tract infections in rural primary healthcare in Guangdong province, China: a cross-sectional study

He,

Li,

Wang

et al. 2023

BMJ Open

View full text Add to dashboard Cite

ObjectivesThe objective of this study is to understand the characteristics and patterns of the first antibiotic prescriptions for children with acute respiratory infections (ARIs) in rural primary healthcare (PHC) in Guangdong province, China.DesignCross-sectional study.Setting and participantsWe used prescription data generated from the electronic medical record system of 37 township hospitals in two counties of Shaoguan City, Guangdong province. 46 699 first prescriptions for ARIs in children aged 0–18 years were screened from 444 979 outpatient prescriptions recorded between November 2017 and October 2018.Outcome measuresDescriptive analyses were used to report sociodemographic characteristics and antibiotic prescribing profiles. χ2analysis and binary logistic regression were used to analyse the factors associated with antibiotic prescriptions in children.ResultsOf the 46 699 sampled cases, 83.00% (n=38 759) received at least one antibiotic as part of their first prescription. Of the 38 759 sampled cases treated with antibiotics, 40.76% (n=15 799), 56.15% (n=21 762) and 31.59% (n=12 244) received parenteral antibiotics, broad-spectrum antibiotics and two or more kinds of antibiotics, respectively. Multivariable analysis showed that children aged ≤5 years were less likely to be prescribed with antibiotics than those aged 16–18 years (OR 0.545, p<0.001). Those with health insurance were more likely to be prescribed with antibiotics than those without health insurance (OR 1.677, p<0.001).ConclusionsMisuse and overuse of antibiotics were found in the prescriptions of children with ARIs in rural PHC. Antibiotic stewardship programme should be established to reduce the level of antibiotic prescriptions among children with ARIs in rural PHC, especially regarding the prescriptions of broad-spectrum antibiotics and parenteral antibiotics, tailored to different ages, sex and health insurance groups.

show abstract

Section: Discussionmentioning

confidence: 99%

Antibiotic prescription for children with acute respiratory tract infections in rural primary healthcare in Guangdong province, China: a cross-sectional study

He,

Li,

Wang

et al. 2023

BMJ Open

View full text Add to dashboard Cite

show abstract

“…The virus entry can be prevented by masking the positive charges of the viral receptor [45]. In the case of enveloped viruses, negatively charged SPS could interfere in the association of the positively charged glycoprotein of the viral envelope and the cell surface receptor [27,32]. The irreversible encapsulation of the viral particles by sulfated polysaccharides was observed by scanning probe microscopy on the HIN5 influenza virus [46].…”

Section: Inhibition Of Infection By Electrostatic Interactionmentioning

confidence: 99%

“…Moreover, the emergence of viral resistance remained a major limiting factor for the general population and emerged as a major public health problem [ 30 , 31 ]. Furthermore, using antibiotics is still widely practiced in certain parts of the world, which leads to their misuse [ 32 ]. Due to the lack of optimal medication and effective vaccines, the search for alternative natural therapies, such as sulfated marine polysaccharides, is indispensable.…”

Section: Symptoms Of Respiratory Viral Infections and Approved Therapiesmentioning

confidence: 99%

Seaweed Sulfated Polysaccharides against Respiratory Viral Infections

Jabeen

Dutot²,

Fagon³

et al. 2021

Pharmaceutics

View full text Add to dashboard Cite

Respiratory viral infections have been a leading cause of morbidity and mortality worldwide. Despite massive advancements in the virology field, no specific treatment exists for most respiratory viral infections. Approved therapies against respiratory viruses rely almost exclusively on synthetic drugs that have potential side effects, restricting their use. This review aims to present natural marine sulfated polysaccharides possessing promising antiviral activity against respiratory viruses that could be a safe alternative to synthetic broad-spectrum antiviral drugs. The antiviral properties of marine sulfated polysaccharides are presented according to their mechanism of action on different types and strains of respiratory viruses, and the potential limits of their use are discussed.

show abstract

“…This is based on the initial identification of the pathogen causing the disease, which in this case may be viral, bacterial or fungal; being the majority of cases of viral origin, however the bacterial ones tend to be more serious [3,9]. These are treated with the use of antibiotics, which are empirically based on three pillars: epidemiology; resistance profile; rational use of antimicrobials [10].…”

Section: Introductionmentioning

confidence: 99%

“…The importance of knowledge about these pillars is important not only for effective therapy, but also to prevent the development of multiresistant bacteria, which are already becoming a worldwide problem, and, according to WHO estimates,deaths resulting from these agents will be comparable to deaths from oncological causes in 2020 [11,12]. Also, pediatric infections caused by Streptococcus pneumonae include otitis media, sinusitis, occult pneumonia, meningitis, bacteremia, osteomyelitis, septic arthritis, peritonitis and pericarditis [10,13].…”

Section: Introductionmentioning

confidence: 99%

A Retrospective Cohort Analysis of the Treatment of Bacterial Pneumonia Pediatric Cases

Amaral

Leite

Bié

et al. 2023

JAMMR

View full text Add to dashboard Cite

Aims: The present study aims to evaluate the use of antibiotics in the management of bacterial pneumonia in the pediatric sector of a teaching hospital. Study Design: A retrospective and descriptive cross-sectional study. Place and Duration of Study: The pediatrics sector of the Julio Bandeira University Hospital (HUJB), Brazil from September 2017 to December 2021. Methodology: A total of 734 medical records were analyzed, based on two groups: a) For those subjects who adhered to the protocol (AP) and b) for those who did not (DP), which were already recommended in the agreement described in the guidelines of hospital. The data were analyzed in a descriptive and exploratory way to evaluate the distribution and characterize the study population, so that the categorical variables were presented in the form of absolute (n) and relative (%) frequencies, while the continuous variables were evaluated through measures of central tendency and dispersion. As the data distribution did not adhere to normality, the differences between the proportions of categorical variables were evaluated by the Chi-square test (5% significance level), while the differences between the medians by the U-Mann-Whitney test. Results: The results found indicate greater effectiveness in the group that followed the institution's protocol (95.93%), as well as less use of antibiotics in therapy, making the majority use of monotherapy (74%), and adequacy to the duration of therapy (OR=1.49). In addition, there was an increase in the use of azithromycin during the Covid-19 pandemic. Conclusion: The group that adhered to the protocol stood out over the group that did not adhere to the protocol in terms of greater effectiveness. Of treatment, less use of antibiotics and adequate length of stay for the prescribed treatment. Furthermore, a growth in the use of azithromycin was observed during the years of the Covid-19 pandemic.

show abstract

Rational use of antimicrobials in the treatment of upper airway infections

Cited by 10 publications

References 57 publications

Antibiotic prescription for children with acute respiratory tract infections in rural primary healthcare in Guangdong province, China: a cross-sectional study

Antibiotic prescription for children with acute respiratory tract infections in rural primary healthcare in Guangdong province, China: a cross-sectional study

Seaweed Sulfated Polysaccharides against Respiratory Viral Infections

A Retrospective Cohort Analysis of the Treatment of Bacterial Pneumonia Pediatric Cases

Contact Info

Product

Resources

About