TyG in insulin resistance prediction

Lopes, Wendell Arthur; Oliveira, Gustavo Henrique de Medeiros; Locateli, João Carlos; Simões, Caroline Ferraz

doi:10.1016/j.jped.2019.09.002

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…From triglycerides and glucose concentration was calculated TYG index. The TYG index was calculated according to the following formula [Ln (fasting triglycerides (mg/dl) X fasting glucose (mg/dl)]/2; Ln is the neperian logarithm [ 25 , 26 ]. The TYG index of DMP was higher than CP (CP 8.95 ± 0.06 vs. DMP 10.56 ± 0.16, p < 0.001).…”

Section: Resultsmentioning

confidence: 99%

Chronic supplementation of noni in diabetic type 1-STZ rats: effects on glycemic levels, kidney toxicity and exercise performance

de Oliveira Fernandes,

César,

Melo

et al. 2023

Diabetol Metab Syndr

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Noni is a fruit with potential medicinal use preventing elevated blood glucose levels in diabetes mellitus. Its effects have been attributed to an antioxidant property in several other diseases. However, the effects of noni-chronic supplementation on exercise performance in the presence of diabetes conditions are not known. Thirty-two male Wistar rats were used to verify the effects of chronic noni (Morinda citrifolia L) juice administration on glycemia, triglyceride levels, and its relation to physical performance. In addition, it was verified if chronic noni supplementation is safe for clinical use through kidney morphology analysis. In half of the rats, diabetes mellitus (DM) was induced with STZ. All rats were submitted to an incremental workload running test (IWT) until fatigued so that oxygen consumption and performance indexes (exercise time to fatigue and workload) could be analyzed before noni administration. Then, the control and DM groups received a placebo (saline solution) or noni juice (dilution 2:1) at a dose of 2 mL/kg once a day for 60 days. The result was four groups: control + placebo (CP), control + noni (CN), DM + placebo (DMP), and DM + noni (DMN). Our dose was based on in previous study by Nayak et al. (2011) that observed a significant reduction in glycemia with 2 ml/kg of the noni juice without any toxicity effect cited. Groups were then given a third IWT to verify the effect of the noni juice on exercise performance (exercise time to fatigue, workload, maximal oxygen consumption) and glycemia. Twenty-four hours after the third test, all animals were euthanized and blood and kidneys were removed for posterior analysis. The DM induction with STZ impaired the performance by 39%. Noni administration improved the time to fatigue and workload in DM rats beyond reducing hyperglycemia. These results could be associated with an improved energy efficiency promoted by noni ingestion, since the oxygen consumption was not different between the groups, although the exercise was longer in animals with noni ingestion. Our results provided evidence that chronic noni administration causes kidney damage since increased Bowman’s space area in the control rats, suggesting glomerular hyperfiltration at the same magnitude as the non-treated DM group.In conclusion, chronic noni ingestion promoted glycemic control and improved the performance in DM rats but caused kidney toxicity.

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Section: Resultsmentioning

confidence: 99%

Chronic supplementation of noni in diabetic type 1-STZ rats: effects on glycemic levels, kidney toxicity and exercise performance

de Oliveira Fernandes,

César,

Melo

et al. 2023

Diabetol Metab Syndr

View full text Add to dashboard Cite

show abstract

“…The TyG index is considered as an indicator of insulin resistance and has been associated with various metabolic and physiological alterations. [29][30][31] These alterations include inflammation, hormonal disruptions, and lipid metabolic disturbances, which have all been found to be involved in the development and manifestation of depressive symptoms in individuals with type 2 diabetes. [32][33][34] Despite being a large cross-sectional study that considers potential confounding factors, it is important to acknowledge the limitations of this research.…”

Section: Discussionmentioning

confidence: 99%

Association between triglyceride-glucose index and depression in patients with type 2 diabetes: A cross-sectional study from NHANES

Ren,

Lv,

Wang

2024

Medicine

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This cross-sectional study aimed to examine the association between the triglyceride-glucose (TyG) index and the prevalence of depression in individuals with type 2 diabetes. A nationally representative sample of 3225 individuals with type 2 diabetes was enrolled in this study. Multivariable logistic regression models were used to assess the association between the TyG index and depression, adjusting for potential confounding factors. After adjusting for age, gender, BMI, smoking, alcohol consumption, congestive heart failure, and coronary heart disease, a significant positive association was found between the TyG index and the prevalence of depression in individuals with type 2 diabetes (OR = 1.54, 95% CI: 1.21–1.95). Subgroup analyses showed consistent associations across various demographic and clinical subgroups. This study provides evidence of a significant independent positive association between the TyG index and the prevalence of depression in individuals with type 2 diabetes.

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“…From triglycerides and glucose concentration was calculated TYG index. The TyG index was calculated according to the following formula [Ln (fasting triglycerides (mg/dl) X fasting glucose (mg/dl)]/2; Ln is the neperian logarithm (24,25). The TYG index of DMP was higher than CP (CP 8.95 ± 0.06 vs. DMP 10.56 ± 0.16, p < 0.001).…”

Section: Effect Of Chronic Noni Juice Ingestion On Glucose and Trigly...mentioning

confidence: 99%

Chronic Supplementation of Noni in Diabetic Type 1-Stz Rats: Effects on Glycemic Levels, Kidney Toxity and Exercise Performance

Fernandes

César

Melo

et al. 2023

Preprint

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Thirty-two male Wistar rats were used to verify the effects of chronic noni (Morinda citrifolia L) juice administration on glycemia, triglycerides levels and its relation to physical performance. In addition, it was verified if chronic noni supplementation is safe to clinical use through the kidney morphology analysis. In half of the rats, diabetes mellitus (DM) was induced with STZ. All rats were submitted to an incremental workload running test (IWT) until fatigued so that oxygen consumption and performance indexes (exercise time to fatigue and workload) could be analyzed before noni administration. Then, the control and DM groups received placebo (saline solution) or noni juice (dilution 2:1) at a dose of 2 mL/kg once a day for 60 days. The result was four groups: control + placebo (CP), control + noni (CN), DM + placebo (DMP), and DM + noni (DMN). Groups were then given a third IWT to verify the effect of the noni juice on exercise performance and glycemia. Twenty-four hours after the third test, all animals were euthanized and blood and kidneys were removed for posterior analysis. Noni administration improved the time to fatigue and workload in DM rats by reducing hyperglycemia. These results could be associated with an improved energy efficiency promoted by noni ingestion. However, our results provided evidence that chronic noni administration causes kidney damage since elevated glomerular filtration was observed at the same magnitude as the non-treated DM group. In conclusion, chronic noni ingestion promoted glycemic control and improved the performance in DM rats but caused kidney toxicity.

show abstract

TyG in insulin resistance prediction

Cited by 5 publications

References 6 publications

Chronic supplementation of noni in diabetic type 1-STZ rats: effects on glycemic levels, kidney toxicity and exercise performance

Chronic supplementation of noni in diabetic type 1-STZ rats: effects on glycemic levels, kidney toxicity and exercise performance

Association between triglyceride-glucose index and depression in patients with type 2 diabetes: A cross-sectional study from NHANES

Chronic Supplementation of Noni in Diabetic Type 1-Stz Rats: Effects on Glycemic Levels, Kidney Toxity and Exercise Performance

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