Day-1 PELOD-2 and day-1 “quick” PELOD-2 scores in children with sepsis in the PICU

Zhong, Mianling; Huang, Yuge; Li, Tufeng; Xiong, Lu; Lin, Ting Tse; Li, Miaofen; He, Dongqiang

doi:10.1016/j.jped.2019.07.007

Cited by 12 publications

(10 citation statements)

References 25 publications

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“…Similar observation has been observed with many other studies. Zhong et al 8 in their study observed that 14% of the survivors and 78.6% of the nonsurvivors were ventilated with a significant association with mortality ( p ≤ 0.001). In our study, the serum lactate levels when high were associated with higher mortality as compared to low lactate levels.…”

Section: Discussionmentioning

confidence: 91%

“…In our study, the serum lactate levels when high were associated with higher mortality as compared to low lactate levels. Jat et al 9 and Zhong et al 8 found that serum lactate levels to be significantly higher in nonsurvivors. Blood lactate is frequently used to monitor tissue hypoxia.…”

Section: Discussionmentioning

confidence: 97%

“…Zhong et al 8 in their study found that day 1 PELOD-2 score and day 1 q PELOD-2 score were effective and able to assess the prognosis of children with sepsis in PICU. The AUC obtain for above were 0.916 and 0.802, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Predictive Efficacy of Pediatric Logistic Organ Dysfunction-2 Score in Pediatric Intensive Care Unit of Rural Hospital

Deshmukh

Varma

Damke

et al. 2020

Indian Journal of Critical Care Medicine

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A bstract Aims and objectives Utility of pediatric logistic organ dysfunction-2 (PELOD-2) score on day 1 within 1 hour of admission in predicting mortality in children admitted in pediatric intensive care unit (PICU). Background Various scoring systems aid to evaluate the patient's mortality risk in the intensive care unit (ICU) by assigning a score and predicting the outcome. Critically ill children are characterized by large variations in the normal body homeostasis. These variations can be estimated by the change of the physiological variables from the normal range. Various scores are constructed from deviations of these changed variables. One such score, the PELOD-2 score, is used to predict mortality of patients admitted in PICU. Materials and methods This study was carried out at a tertiary care center in central India to study the utility of PELOD-2 score within 1 hour of admission to predict mortality in patients admitted in PICU. Results Total 129 patients were included in this study with mean age of 67 months. The system with highest admission was central nervous system with 42 children and 16.6% mortality, whereas those 7 patients with hematological system involvement had highest mortality of 28.5%. The mortality rate was 15.55%. In our study for PELOD-2 within 24 hours of admission, the area under receiver operating curve was 0.87 and the Hosmer–Lemeshow test was p = 0.42. Conclusion Pediatric logistic organ dysfunction-2 score in our study had significant association with mortality along with the Hosmer–Lemeshow goodness-of-fit test showing a good prediction of mortality. How to cite this article Deshmukh T, Varma A, Damke S, Meshram R. Predictive Efficacy of Pediatric Logistic Organ Dysfunction-2 Score in Pediatric Intensive Care Unit of Rural Hospital. Indian J Crit Care Med 2020;24(8):701–704.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 97%

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Predictive Efficacy of Pediatric Logistic Organ Dysfunction-2 Score in Pediatric Intensive Care Unit of Rural Hospital

Deshmukh

Varma

Damke

et al. 2020

Indian Journal of Critical Care Medicine

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“…The PELOD-2 score may serve as an optimal measure to monitor the development of disease conditions and predict the outcome when evaluated in continuous time intervals at the time of disease progression (39). A study reported by Zhong et al (32) reported that the PELOD-2 score was effective to assess the prognosis of PICU patients with sepsis and has shown an excellent discriminatory power with 0.916. On the other hand, PRISM-III/IV score and PELOD-2 performance becomes better when sepsis is pronounced (16).…”

Section: Discussionmentioning

confidence: 99%

Meta-Analysis for the Prediction of Mortality Rates in a Pediatric Intensive Care Unit Using Different Scores: PRISM-III/IV, PIM-3, and PELOD-2

Shen

José²

2021

Front. Pediatr.

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Introduction: The risk of mortality is higher in pediatric intensive care units (PICU). To prevent mortality in critically ill infants, optimal clinical management and risk stratification are required.Aims and Objectives: To assess the accuracy of PELOD-2, PIM-3, and PRISM-III/IV scores to predict outcomes in pediatric patients.Results: A total of 29 studies were included for quantitative synthesis in meta-analysis. PRISM-III/IV scoring showed pooled sensitivity of 0.78; 95% CI: 0.72–0.83 and pooled specificity of 0.75; 95% CI: 0.68–0.81 with 84% discrimination performance (SROC 0.84, 95% CI: 0.80–0.87). In the case of PIM-3, pooled sensivity 0.75; 95% CI 0.71–0.79 and pooled specificity 0.76; 95% CI 0.73–0.79 were observed with good discrimination power (SROC, 0.82, 95% CI 0.78–0.85). PELOD-2 scoring system had pooled sensitivity of 0.78 (95% CI: 0.71–0.83) and combined specificity of 0.75 (95% CI: 0.68–0.81), as well as good discriminating ability (SROC 0.83, 95% CI: 0.80–0.86) for mortality prediction in PICU patients.Conclusion: PRISM-III/IV, PIM-3, and PELOD-2 had good performance for mortality prediction in PICU but with low to moderate certainty of evidence. More well-designed studies are needed for the validation of the study results.

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“…They also concluded that in developing countries, the PELOD-2 score can be used to standardize the diagnosis of sepsis using the new sepsis definition which includes the involvement of organ dysfunction. [ 14 ]…”

Section: Discussionmentioning

confidence: 99%

Validation of the vasoactive-inotropic score in predicting pediatric septic shock mortality: A retrospective cohort study

Pudjiadi¹,

Pramesti²,

Pardede³

et al. 2021

Int J Crit Illn Inj Sci

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Introduction: Mortality in pediatric septic shock remains very high. Vasoactive-inotropic score (VIS) is widely used to predict prognosis in patients with heart disease. It is a simple method that was initially used as a predictor of morbidity and mortality in postoperative patients with congenital heart diseases. Previous reports showed that high VIS score was associated with high mortality in pediatric sepsis. However, its discriminative value remains unclear. We aim to explore the discriminative value of VIS in predicting mortality in pediatric septic shock patients. Methods: We conducted a retrospective cohort study on medical records of septic shock patients who received care in the pediatric intensive care unit (PICU). We screened medical records of pediatric patients which were diagnosed with septic shock and admitted to the PICU and received vasoactive/inotropic score for more than 8 h. Other supporting examination results were recorded, such as organ function evaluation for calculation of Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score. The outcome of patients was recorded. The receiver operating curve was constructed to calculate the area under the curve (AUC), sensitivity, and specificity of each cutoff point. Results: We obtained the optimum cutoff point of VIS > 11 with 78.87% sensitivity and 72.22% specificity. AUC positive was 0.779 ( P < 0.001); predictive value and negative predictive value were 91.80% and 46.43%, respectively. Conclusion: VIS > 11 has a good ability to predict mortality in children with septic shock.

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Day-1 PELOD-2 and day-1 “quick” PELOD-2 scores in children with sepsis in the PICU

Cited by 12 publications

References 25 publications

Predictive Efficacy of Pediatric Logistic Organ Dysfunction-2 Score in Pediatric Intensive Care Unit of Rural Hospital

Predictive Efficacy of Pediatric Logistic Organ Dysfunction-2 Score in Pediatric Intensive Care Unit of Rural Hospital

Meta-Analysis for the Prediction of Mortality Rates in a Pediatric Intensive Care Unit Using Different Scores: PRISM-III/IV, PIM-3, and PELOD-2

Validation of the vasoactive-inotropic score in predicting pediatric septic shock mortality: A retrospective cohort study

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