Association between the FTO gene polymorphism and obesity in Brazilian adolescents from the Northeast region

Rodrigues, Liliane dos Santos; Santos, Alcione Miranda dos; Lima, Mayara Ingrid Sousa; Pereira, Silma Regina Ferreira

doi:10.1016/j.jped.2019.05.006

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…16 Sovio et al found that the relationship between the A allele and the BMI was inversed for children below 2.5 years of age. 24 However, some did not find any influence by genotype, 25 while others found it only in girls. 26 Because obesity is difficult to reverse once established, 27 it is important to identify early risk factors as well as protective factors for a healthy weight pattern.…”

Section: Introductionmentioning

confidence: 94%

Breastfeeding moderates the relationship between fat mass and obesity‐associated gene rs9939609 and body mass index among adolescents

Kanders

Nilsson

Åslund

2021

Obesity Science & Practice

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Objective: Breastfeeding, which is important for early growth, is a possible moderator of genetic influence, such as the effect of the fat mass and obesityassociated gene (FTO) on body mass index (BMI). The aim of this study was to assess the moderating effect of breastfeeding duration on the relationship between FTO rs9939609 and BMI in a Caucasian sample. Methods: Adolescents born in 1997 and in 1999, who were living in the Swedish county Västmanland in 2012, were invited to participate in the Survey of Adolescent Life in Västmanland. The adolescents and their parents completed self-reported questionnaires in 2012, 2015, and 2018. Genotyping of rs9939609 T > A polymorphism was conducted from saliva DNA samples. Interaction effects of parental reported breastfeeding duration in months, including regions of significance, on the relationship between rs9939609 and BMI plus overweight were assessed.Results: Considering physical activity levels, parental reported breastfeeding duration was a moderator of the relationship between rs9939609 and BMI for the younger (regions of significance = <1.6 and >28.1 months) and older adolescents (region of significance = >19.9 months), but not for the young adults. Plots of the association between breastfeeding duration and BMI showed higher BMI for AA with short breastfeeding, but lower BMI with longer breastfeeding than AT and TT.Longer breastfeeding lowered the odds for overweight among the younger adolescents, especially among AA individuals. Conclusion:Rs9939609 AA individuals were more susceptible than AT and TT individuals to both short and long breastfeeding durations, which is consistent with the differential susceptibility hypothesis. FTO rs9939609 AA might be a plasticityThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Section: Introductionmentioning

confidence: 94%

Breastfeeding moderates the relationship between fat mass and obesity‐associated gene rs9939609 and body mass index among adolescents

Kanders

Nilsson

Åslund

2021

Obesity Science & Practice

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“…Weighted frequency of rs9939609 A allele in subgroups of the Brazilian population. Effect of SNP rs9939609 (FTO) on being overweight or obese amongst Brazilian children and adolescents with the AA genotype vs those with the TT genotype[34][35][36][37].…”

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confidence: 99%

Genetic Epidemiology in Latin America: Identifying Strong Genetic Proxies for Complex Disease Risk Factors

Bonilla

Baccarini

2020

Genes

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Epidemiology seeks to determine the causal effects of exposures on outcomes related to the health and wellbeing of populations. Observational studies, one of the most commonly used designs in epidemiology, can be biased due to confounding and reverse causation, which makes it difficult to establish causal relationships. In recent times, genetically informed methods, like Mendelian randomization (MR), have been developed in an attempt to overcome these disadvantages. MR relies on the association of genetic variants with outcomes of interest, where the genetic variants are proxies or instruments for modifiable exposures. Because genotypes are sorted independently and at random at the time of conception, they are less prone to confounding and reverse causation. Implementation of MR depends on, among other things, a strong association of the genetic variants with the exposure, which has usually been defined via genome-wide association studies (GWAS). Because GWAS have been most often carried out in European populations, the limited identification of strong instruments in other populations poses a major problem for the application of MR in Latin America. We suggest potential solutions that can be realized with the resources at hand and others that will have to wait for increased funding and access to technology.

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“…Entre os portadores de pelo menos um alelo de risco em indivíduos homozigotos (AT), há uma probabilidade 1,7 vezes maior de desenvolverem obesidade, quando comparados a indivíduos sem o alelo de risco (FRAYLING et al, 2007;RODRIGUES et al, 2020). Em crianças, a prevalência desse polimorfismo abrange cerca de 21% daquelas sem o alelo de risco e cerca de 28% com a presença de pelo menos um alelo de risco, ao passo que as crianças com o polimorfismo (AA) possuem maiores valores de IMC (EMOND et al, 2017;ULLOA et al, 2020).…”

Section: Fto E Risco Cardiometabólicounclassified

Consumo e padrão alimentar, polimorfismos genéticos e fatores de risco cardiometabólico em crianças

Kiepper¹

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Crianças com consumo alimentar inadequado apresentam maior predisposição à ocorrência de doenças crônicas, principalmente na presença de modificações genéticas. Os padrões alimentares compreendem os alimentos frequentemente consumidos e um padrão de baixo valor nutricional, associa-se ao aumento do risco cardiometabólico, principalmente em indivíduos com Polimorfismos de Nucleotídeo Único (SNP’s) nos genes FTO, MC4R e MTMR9, podendo comprometer a saúde por toda a vida. O objetivo deste estudo foi investigar a associação do padrão alimentar e consumo de macronutrientes com fatores de risco cardiometabólico, na presença de polimorfismos genéticos em crianças. Trata-se de um estudo transversal, realizado com 258 crianças de 4 a 7 anos pertencentes a uma coorte retrospectiva em Viçosa, Minas Gerais, Brasil. As medidas antropométricas realizadas foram peso, estatura e perímetro da cintura. Os exames bioquímicos avaliados foram: glicemia, colesterol total, LDL-c, HDL-c e triglicerídeos (TG), e a partir destes, foram calculados o colesterol não HDL e o índice triglicerídeos-glicemia (TyG). Aferiu-se a pressão arterial para cálculo da pressão arterial média (PAM). O consumo alimentar foi avaliado por meio de três registros alimentares, aplicados em dias não consecutivos, sendo um de final de semana. A coleta do material genético se deu através do swab oral e os polimorfismos associados aos genes FTO, MC4R e MTMR9 também foram avaliados através swab oral. Aplicou-se a regressão linear múltipla, para avaliar a associação dos padrões alimentares e consumo de nutrientes com os fatores de risco cardiometabólico, estratificada pelas categorias dos genes. A prevalência de excesso de peso entre as crianças foi de 22,1% e a de polimorfismo no gene FTO de 20,2% (AA). Identificou- se cinco padrões: “Tradicional”, “Ultraprocessado”, “Leite com achocolatado”, “Lanche” e “Natural”. Entre as crianças com o polimorfismo no gene FTO, foi observada associação com o padrão “Ultraprocessado” e o índice TyG (β = 0,06; IC95%: 0,01 - 0,11) e com os triglicerídeos (β = 7,47; IC95%: 0,73 – 14,21). Já entre as crianças com um alelo de risco (AT), identificou-se associação do padrão “Leite e Achocolatado” com o índice TyG (β = 0,03; IC 95%:0,00 - 0,07). Na análise de consumo, observou-se que crianças portadoras do gene MTMR9 (AG/AA) apresentaram maiores médias de LDL-c. Crianças com apenas um alelo de risco nostrês genes e com maior consumo de macronutrientes, apresentaram maiores valores de PAM, TyG, TG e glicemia. As crianças com polimorfismo nos genes e com maior consumo de carboidrato, gordura poli-insaturada e saturada, lipídeos e proteína, apresentaram maiores valores de IMC, TyG, PAM, TG, HDL-c e a glicemia. Os resultados deste estudo apontam que entre as crianças com polimorfismo no gene FTO houve associação entre o padrão ultra processado e fatores de risco cardiometabólico, assim como nas crianças portadoras de polimorfismo nos três genes e com maior consumo de macronutrientes, apresentaram maiores valores dos marcadores de risco cardiometabólico. Assim, o consumo alimentar adequado mostra-se como um fator protetor à ocorrência de alterações cardiometabólicas, principalmente em indivíduos portadores de polimorfismos nos genes FTO, MC4R e MTMR9. Palavras-chave: Padrão alimentar. Risco cardiometabólico. Single nucleotide polymorphisms. Criança.

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Association between the FTO gene polymorphism and obesity in Brazilian adolescents from the Northeast region

Cited by 7 publications

References 26 publications

Breastfeeding moderates the relationship between fat mass and obesity‐associated gene rs9939609 and body mass index among adolescents

Breastfeeding moderates the relationship between fat mass and obesity‐associated gene rs9939609 and body mass index among adolescents

Genetic Epidemiology in Latin America: Identifying Strong Genetic Proxies for Complex Disease Risk Factors

Consumo e padrão alimentar, polimorfismos genéticos e fatores de risco cardiometabólico em crianças

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