Abnormal thymic stromal lymphopoietin expression in the gastrointestinal mucosa of patients with eosinophilic gastroenteritis

Guo, Hongmei; Ji, Xiaolan; Yang, Guang; Yu, Jin

doi:10.1016/j.jped.2018.11.012

Cited by 3 publications

(1 citation statement)

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“…Long TSLP can activate mast cells, dendritic cells, and T cells by binding to the TSLP receptor (TSLPR), and has pro-inflammatory functions. In 2020, Guo et al [20] noted that the mRNA expression of long TSLP showed a significant and positive correlation with peak eosinophilic counts in the gastrointestinal mucosa of patients with EGE. Conversely, short TSLP showed a negative correlation.…”

Section: Pathogenesismentioning

confidence: 99%

Eosinophilic gastroenteritis: Pathogenesis, diagnosis, and treatment

Ruan

Liu

et al. 2023

Chinese Medical Journal

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Eosinophilic gastroenteritis (EGE) is a gastrointestinal disorder of unclear etiology that is characterized by eosinophilic infiltration of the stomach and small intestine, and consists of mucosal, muscular, and serosal subtypes. Eosinophilic infiltration of the gastrointestinal tract is a fundamental histopathological characteristic of EGE and is driven by several T-helper type 2 (Th2)-dependent cytokines and induced by food allergy. Due to the lack of a diagnostic gold standard, EGE has a high rate of delayed diagnosis or misdiagnosis. However, several new diagnostic strategies have been developed, such as novel genetic biomarkers and imaging tests. Although dietary therapy and corticosteroids remain the common choices for EGE treatment, recent decades have seen the emergence of novel treatment alternatives, such as biologics that target particular molecules involved in the pathogenic process. Preliminary investigations and clinical trials have demonstrated the efficacy of biologics and provided additional insights for the era of refractory or corticosteroid-dependent EGE biologics.

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Section: Pathogenesismentioning

confidence: 99%